Relationships between sleep quality and glucose regulation in normal humans

Scheen, André; Byrne, Maria; Plat, Laurence; Leproult, Rachel; Cauter, Eve Van

doi:10.1152/ajpendo.1996.271.2.e261

Cited by 90 publications

(101 citation statements)

References 22 publications

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“…CONCLUSIONS -This long-term study supports the hypothesis, based on earlier experimental research, that sleep problems are associated with alterations in metabolic variables, with glucose intolerance, and with type 2 diabetes (11,12,23). At the same time, our study expands the earlier findings by showing that sleep disturbances are able to predict future diabetes in middle-aged men.…”

Section: Independent Predictors Of Diabetes At Follow-upsupporting

confidence: 89%

Incidence of Diabetes in Middle-Aged Men Is Related to Sleep Disturbances

et al. 2004

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OBJECTIVE -Sleep deprivation in healthy men has been experimentally found to result in disturbances in glucose metabolism and in sympathovagal imbalance. The aim of the present study was to investigate whether sleep disturbances and elevated resting heart rate are associated with increased risk of developing diabetes. RESEARCH DESIGN AND METHODS-A group of 6,599 initially healthy, nondiabetic men aged 44.5 Ϯ 4.0 years took part in a prospective, population-based study in Malmö , Sweden. The incidence of diabetes during a mean follow-up of 14.8 Ϯ 2.4 years was examined in relation to self-reported difficulties in falling asleep and resting heart rate at baseline. Diabetes was assessed at follow-up in all subjects by questionnaire and in a subgroup of 1,551 men by blood glucose measurement.RESULTS -A total of 615 (9.3%) subjects reported either difficulties in falling asleep or regular use of hypnotics (seen as markers of sleep disturbances), and 158 (2.4%) subjects reported both of these. Altogether, 281 (4.3%) of the men developed diabetes during the follow-up period. Logistic regression models showed difficulties in falling asleep or regular use of hypnotics (odds ratio [OR] 1.52 [95% CI 1.05-2.20]) and resting heart rate (OR per 10 bpm 1.13 [0.99 -1.30]) to be associated with development of diabetes when full adjustments were made for baseline age, biological risk factors, lifestyle, family history of diabetes, and social class.CONCLUSIONS -The results suggest that sleep disturbances and, possibly, elevated resting heart rate, in middle-aged men, are associated with an increased risk of diabetes. Diabetes Care 27:2464 -2469, 2004S leep problems are common in the adult population according to several epidemiological studies (1), as the amounts of hypnotics prescribed reflect as well (2). Although long-term sleep loss is often secondary to somatic or psychiatric illness (3), it appears that insomnia may also play a more central role in the pathogenesis of somatic illness and metabolic dysregulation (4).Divergent sleep duration, either excessively long or excessively short, has been shown (5), together with selfreported poor sleep quality (6), to be a predictor of overall mortality. Sleep disturbances are associated with increased levels of cardiovascular risk factors and coronary artery disease mortality (7,8). The sleep cycle is closely related to endocrine and metabolic functioning and to sympathovagal balance, with sleep deprivation having negative consequences for these systems. Sleep disturbances are associated with an increased concentration of cortisol and such indicators of increased sympathetic activity as elevations in pulse rate, body temperature, and epinephrine secretion (9,10). Experimentally, sleep deprivation has been shown to negatively affect glucose metabolism and to enhance variables associated with type 2 diabetes (11). An elevated heart rate is a risk marker for cardiovascular disease and may, like sleep problems, reflect increased psychosocial stress.A clinical study has shown sleep disord...

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Section: Independent Predictors Of Diabetes At Follow-upsupporting

confidence: 89%

Incidence of Diabetes in Middle-Aged Men Is Related to Sleep Disturbances

et al. 2004

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“…Furthermore, six hours before baseline determination, they had the same light meal containing 20% of theoretic energy need. Finally, in the present study the subjects were not allowed to sleep, which permitted the assessment of the effect of the diurnal cycle and food intake, independently of sleep related metabolic changes 23 ± some of which may affect leptin levels. 24 In the present study, the circadian cycle was demonstrated by cortisol changes, and the lack of sleep-related hormonal disturbances by the absence of sleep-related growth hormone peak (data not shown).…”

Section: Discussionmentioning

confidence: 99%

Short term response of circulating leptin to feeding and fasting in man: influence of circadian cycle

et al. 1998

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OBJECTIVE: To investigate whether acute feeding induces changes in circulating leptin levels in humans and whether these changes vary according to nycthemeral cycle. METHODS: First experiment. Eighteen male subjects were given a fatty meal at 08.00 h. Blood sampling was performed for 10 h following this meal. Second experiment. Thirteen male subjects were given either a mixed meal or remained fasting either at night (starting at 01.00 h) or during the day (starting at 13.00 h). Blood samples were drawn every hour for a period of 8 h. RESULTS: First experiment. Serum leptin levels increased progressively from a mean (s.d.) baseline of 3.8 AE 2.2 ngaml to a value of 4.5 AE 2.7 ngaml (P`0.01) 8 h after the fatty meal. Second experiment. During the day, serum leptin levels increased progressively from 2.65 AE 1.7 to 3.34 AE 2.2 ngaml (P`0.001) 6 h after the test-meal and decreased from 2.68 AE 1.5 to 1.9 AE 1.1 ngaml (P`0.001) 8 h after the beginning of the fasting experiment. Similar results were obtained at night. No statistically signi®cant differences in leptin levels were observed between day and night sessions in response to feeding (mean area under the curve: 3.0 AE 4.1 vs 4.1 AE 4.1 ngaml) and fasting (72.9 AE 2.2 vs 71.5 AE 2.2 ngaml). CONCLUSION: In two independent experiments, human serum leptin levels increase following food intake. This response is not in¯uenced by nycthemeral cycle.

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“…[10,11] By contrast, sleep dysfunction is linked to the development of physical and psychological issues including cardiovascular problems, diabetes, obesity, anxiety, and all-cause high rates of death [12] and number of studies have supported that the metabolic rate related to interference of normal sleep behaviors may related to the development of obesity, cardiovascular disease, diabetes, and diabetes. [13][14][15][16][17][18][19][20][21][22][23][24][25][26] In the current study, the authors applied crosssectional study that explore the association between Body Mass Index (BMI) and sleep pattern among undergraduate female students of health colleges in Qassim University.…”

Section: Introductionmentioning

confidence: 99%

Association between sleep pattern and body mass index among undergraduate health colleges’ students at Qassim University, Saudi Arabia

Alfarhan¹,

Matrouk²,

AlGaowba³

et al. 2018

JNEP

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Background and objective: Better quality and adequate amount of sleep are essential to have better cognitive performance and by contrast, poor bedrest is related to a diminishing of cognitive and psychological functioning and deteriorating physical health. Recently the quality of sleep among various segments of the population has become a focus of continuous research and investigations, where insufficient sleep may lead to adverse cardio-metabolic effects by influencing body weight, blood pressure, and glucose tolerance. The objective of this study is to explore the associations between sleep patterns and Body Mass Index (BMI) among undergraduate female students in health colleges. Methods: Across-sectional study was utilized among 288 of undergraduate female students who represent 30% of all undergraduate students in health Colleges of female section, Qassim University. The data regarding their sleeping pattern was collected and calculated by using a validated self-report questioner (Pittsburgh Sleep Quality Index) and Body Mass. Results: According to PSQI scoring, both categories good and poor sleep maximum according to PSQI scoring; both categories good sleep and poor sleep maximum participant's BMI was normal but no statistically significant association was seen between BMI of poor sleep was higher in overweight and obese participants from all departments and also no statistically significant association was seen between poor sleep and body mass index of participant As for the sleep quality as a single question and sleep duration in relation to BMI for different specialties, only for nursing students there was a statistically significant difference of sleep quality/duration in relation to their BMI. Conclusions: Frequency of poor sleep was higher in overweight and obese participants but as per findings there was no statistically significant association was detected between PSQI score and BMI of participants.

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Relationships between sleep quality and glucose regulation in normal humans

Cited by 90 publications

References 22 publications

Incidence of Diabetes in Middle-Aged Men Is Related to Sleep Disturbances

Incidence of Diabetes in Middle-Aged Men Is Related to Sleep Disturbances

Short term response of circulating leptin to feeding and fasting in man: influence of circadian cycle

Association between sleep pattern and body mass index among undergraduate health colleges’ students at Qassim University, Saudi Arabia

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