Relationships between surface free energy, surface texture parameters and controlled drug release in hydrophilic matrices

Changes in surface properties of dental alloys with atmospheric plasma irradiation

“…Marshall et al 1) found that cohesion between similar molecules/atoms affects intermolecular attractions, and Combe et al 2) stated that knowledge of the reactivity or energy of surfaces, and in particular their interaction with fluids, was very important. Assessment of surface energy has been used to analyze the surface properties of medical biomaterials; such as intraocular lenses 3) , drug tablets 4) and orthopedic implants 5) , and also to analyze cell adhesion to dental implants 6) , resin adhesion to tooth crown restorations 7) and dentures 2,8) , as well as tooth substance adhesion to enamel 9) and dentin 10) . The occurrence of surface bonds can be investigated by analyzing transitions of surface energy.…”

In situ3D nanoscale advanced imaging algorithms with integrated chemical imaging for the characterisation of pharmaceuticals

“…Typically, nanoscale imaging is conducted using white light and variable focus prolometry techniques, confocal and atomic force microscopy (AFM). [8][9][10][11] However, imaging a large area is a challenge as, with confocal microscopy and prolometric techniques, scanning of the full surface of the pharmaceutical formulation is not possible. Currently, AFM is considered the most powerful and versatile technique for nanoscale imaging and multiple studies have successfully employed this technique, either alone or in combination with another imaging technique, to quantitatively assess surface topography.…”

“…Currently, AFM is considered the most powerful and versatile technique for nanoscale imaging and multiple studies have successfully employed this technique, either alone or in combination with another imaging technique, to quantitatively assess surface topography. 9,10,12 A study conducted by Saurí et al (2015), investigated the relationship between surface free energy, surface texture parameters and controlled drug release in hydrophilic matrices. 10 Contact angle was used to determine the surface energy and both confocal microscopy and AFM were utilised for the surface characterisation of the hydrophilic matrix tablets.…”

“…9,10,12 A study conducted by Saurí et al (2015), investigated the relationship between surface free energy, surface texture parameters and controlled drug release in hydrophilic matrices. 10 Contact angle was used to determine the surface energy and both confocal microscopy and AFM were utilised for the surface characterisation of the hydrophilic matrix tablets. Additionally, images of a selected area of tablet surface (636.61 mm  477.25 mm) were acquired before and aer wetting with water using confocal microscopy.…”

“…Although this area is larger than that one can scan with AFM, however, it is not large enough to capture the complete tablet surface. 10 Similarly, a study by Paredes et al (2006), monitored the real-time swelling of a polymer (poly(p-phenylene terepthalamide)) using AFM. The captured images displayed the topographical changes in the polymer surface aer oxygen plasma treatment.…”