Relationships between trace elements and atherosclerosis

Aalbers, Th.G.; Houtman, J.P.W.

doi:10.1016/0048-9697(85)90133-0

Cited by 43 publications

(18 citation statements)

References 31 publications

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“…In the present study, the serum magnesium, ionized calcium, sodium and potassium levels were significantly lower in the AMI patients, which was similar to those which were seen in other studies [12][13][14][15]. Our study also supported the hypothesis that the alterations in the electrolyte levels could prompt the pathological events in coronary heart diseases [12].…”

Section: Discussionsupporting

confidence: 81%

The Prospect of Serum Magnesium and an Electrolyte Panel as an Adjuvant Cardiac Biomarker in the Management of Acute Myocardial Infarction

Ramesh

Murugaiyan²,

Gopal³

et al. 2013

JCDR

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Background: Ischemic heart disease accounts 12.2% deaths worldwide. Serum magnesium (Mg+) status is often ignored in Acute Myocardial Infarction (AMI). Studies showed alterations in the levels of serum electrolytes including magnesium in AMI. Aim:To evaluate serum Mg+ and other electrolytes as adjuvant markers in the diagnosis of AMI. Design and Settings:Case control study was conducted in South Indian male population with AMI within six hours of onset of symptoms. Patients and Methods:Study includes sixty patients with AMI and 100 controls. Serum electrolytes were estimated using electrolyte analyzer. Data were compared by using student't' test. ROC was drawn to find out optimum cutoff for diagnosing AMI. Pearson's correlation was done to see the association among the markers.

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Section: Discussionsupporting

confidence: 81%

The Prospect of Serum Magnesium and an Electrolyte Panel as an Adjuvant Cardiac Biomarker in the Management of Acute Myocardial Infarction

Ramesh

Murugaiyan²,

Gopal³

et al. 2013

JCDR

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“…11 Finally, several autopsy studies have found associations between tissue lead or cadmium levels and atherosclerotic lesions. 37,38 Several limitations of this study should be considered. The cross-sectional design and the use of prevalent cases of PAD limit conclusions regarding the direction or causality of the observed associations.…”

Section: Discussionmentioning

confidence: 99%

Lead, Cadmium, Smoking, and Increased Risk of Peripheral Arterial Disease

et al. 2004

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Background— Lead and cadmium exposure may promote atherosclerosis, although the cardiovascular effects of chronic low-dose exposure are largely unknown. The objective of the present study was to evaluate the association between blood levels of lead and cadmium and peripheral arterial disease. Methods and Results— We analyzed data from 2125 participants who were ≥40 years of age in the 1999 to 2000 National Health and Nutrition Examination Survey (NHANES). Peripheral arterial disease was defined as an ankle brachial index <0.9 in at least 1 leg. Lead and cadmium levels were measured by atomic absorption spectrometry. After adjustment for demographic and cardiovascular risk factors, the ORs of peripheral arterial disease comparing quartiles 2 to 4 of lead with the lowest quartile were 1.63 (95% CI, 0.51 to 5.15), 1.92 (95% CI, 0.62 to 9.47), and 2.88 (95% CI, 0.87 to 9.47), respectively ( P for trend=0.02). The corresponding ORs for cadmium were 1.07 (95% CI, 0.44 to 2.60), 1.30 (95% CI, 0.69 to 2.44), and 2.82 (95% CI, 1.36 to 5.85), respectively ( P for trend=0.01). The OR of peripheral arterial disease for current smokers compared with never smokers was 4.13. Adjustment for lead reduced this OR to 3.38, and adjustment for cadmium reduced it to 1.84. Conclusions— Blood lead and cadmium, at levels well below current safety standards, were associated with an increased prevalence of peripheral arterial disease in the general US population. Cadmium may partially mediate the effect of smoking on peripheral arterial disease.

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“…Raised plasma levels of the essential metalloelement copper have also been reported in patients with homocysteinaemia (Dudman & Wilcken, 1983) and may be a contributory factor in atherogenesis (Aalbers & Houtman, 1985;Iskra et al, 1993). Copper can catalyze the oxidation of thiols leading to the reduction of oxygen and the generation of hydrogen peroxide (H 2 O 2 ; Cavallini et al, 1969).…”

Section: Introductionmentioning

confidence: 99%

Investigation of the inhibitory effects of homocysteine and copper on nitric oxide‐mediated relaxation of rat isolated aorta

Emsley

Jeremy

Gomes

et al. 1999

British J Pharmacology

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Elevated plasma levels of homocysteine (HC) and copper have both been associated with the development of inflammatory vascular diseases, such as atherosclerosis. In this study, the effects of a combination of HC and copper on nitric oxide (NO)‐mediated relaxation of isolated rat aortic rings were investigated. Exposure to HC (10–100 μM; 30 min) had no effect on relaxation to acetylcholine (ACh; 0.01–10 μM, n=4). Pre‐incubation of aortic rings with a higher concentration of HC for an extended period (1 mM; 180 min) significantly inhibited endothelium‐dependent relaxation (n=4), but this inhibition was prevented by the presence of the copper chelator bathocuprione (10 μM, 180 min, n=6). Exposure to HC (100 μM) and copper (10–100 μM; 30 min) caused a copper concentration‐dependent inhibition of endothelium‐dependent relaxation (n=4). This inhibitory effect was reduced in the presence of either superoxide dismutase (SOD; 100 u ml−1; n=4) or catalase (100 u ml−1; n=4), and further reduced by the presence of both enzymes (n=5). HC and copper (100 μM; 30 min) significantly inhibited endothelium‐independent relaxation to glyceryl trinitrate (0.01–10 μM; n=8). In contrast, HC (1 mM), alone or in combination with copper (100 μM), did not inhibit relaxation to the endothelium‐independent relaxant sodium nitroprusside (0.01–10 μM; n=4). These data indicate that the presence of copper greatly enhances the inhibitory actions of HC on NO‐mediated relaxation of isolated aortic rings. The reduction of inhibition by catalase and SOD indicates a possible role for copper‐catalyzed generation of superoxide and hydrogen peroxide leading to an increased inactivation or decreased production of endothelium‐derived NO. British Journal of Pharmacology (1999) 126, 1034–1040; doi:10.1038/sj.bjp.0702374

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Relationships between trace elements and atherosclerosis

Cited by 43 publications

References 31 publications

The Prospect of Serum Magnesium and an Electrolyte Panel as an Adjuvant Cardiac Biomarker in the Management of Acute Myocardial Infarction

The Prospect of Serum Magnesium and an Electrolyte Panel as an Adjuvant Cardiac Biomarker in the Management of Acute Myocardial Infarction

Lead, Cadmium, Smoking, and Increased Risk of Peripheral Arterial Disease

Investigation of the inhibitory effects of homocysteine and copper on nitric oxide‐mediated relaxation of rat isolated aorta

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