Relationships Between Traditional Chinese Medicine Constitution and Age-Related Cognitive Decline in Chinese Centenarians

Sun, Zhen‐Gao; Ping, Ping; Li, Yulong; Feng, Long; Liu, Fan; Zhao, Yali; Yao, Yao; Zhang, Pei; Fu, Shihui

doi:10.3389/fnagi.2022.870442

Cited by 8 publications

(11 citation statements)

References 23 publications

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“…Yi-Qi-Huo-Xue recipe is a unique prescription for Qi-deficiency and blood stasis ( Wu et al, 2014 ). The relationship between TCM constitution and age-related cognitive decline has been demonstrated in a larger sample of elderly people ( Sun et al, 2022 ). Evidence already exists that TCM constitution is related to emotions.…”

Section: Discussionmentioning

confidence: 99%

Care patterns and Traditional Chinese Medicine constitution as factors of depression and anxiety in patients with systemic sclerosis: A cross-sectional study during the COVID-19 pandemic

Kong

Chen²,

Dai³

et al. 2023

Front. Integr. Neurosci.

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ObjectiveCare patterns and Traditional Chinese Medicine (TCM) constitution affects the emotion and health of patients with systemic sclerosis (SSc) while the prevalence of COVID-19 may aggravate such patients’ emotion and health. We investigated the depression and anxiety levels of patients with SSc during the pandemic to identify the correlation between care patterns, TCM constitution, and patients’ emotion.Materials and methodsThis was a cross-sectional study. Patients with SSc and healthy individuals were surveyed using the patient health questionnaire-9, generalized anxiety disorder-7, and constitution in Chinese medicine questionnaire and a modified care pattern questionnaire. Factors correlated with depression and anxiety were screened using univariate and multivariate logistic regression analyses.ResultsA total of 273 patients with SSc and 111 healthy individuals were included in the analysis. The proportion of patients with SSc who were depressed was 74.36%, who had anxiety was 51.65%, and who experienced disease progression during the pandemic was 36.99%. The proportion of income reduction in the online group (56.19%) was higher than that in the hospital group (33.33%) (P = 0.001). Qi-deficiency [adjusted odds ratio (OR) = 2.250] and Qi-stagnation (adjusted OR = 3.824) constitutions were significantly associated with depression. Remote work during the outbreak (adjusted OR = 1.920), decrease in income (adjusted OR = 3.556), and disease progression (P = 0.030) were associated with the occurrence of depression.ConclusionChinese patients with SSc have a high prevalence of depression and anxiety. The COVID-19 pandemic has changed the care patterns of Chinese patients with SSc, and work, income, disease progression, and change of medications were correlates of depression or anxiety in patients with SSc. Qi-stagnation and Qi-deficiency constitutions were associated with depression, and Qi-stagnation constitution was associated with anxiety in patients with SSc.Trial registrationhttp://www.chictr.org.cn/showproj.aspx?proj=62301, identifier ChiCTR2000038796.

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Section: Discussionmentioning

confidence: 99%

Care patterns and Traditional Chinese Medicine constitution as factors of depression and anxiety in patients with systemic sclerosis: A cross-sectional study during the COVID-19 pandemic

Kong

Chen²,

Dai³

et al. 2023

Front. Integr. Neurosci.

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“…The study of TCM constitution is the most crucial part of "treating the disease before it happens." Currently, TCM constitution identi cation has been used as one of the methods for screening and preventing diseases in many elds [29]. Tongue image is the most easily observed, collected, and judged index in clinical practice.…”

Section: Discussionmentioning

confidence: 99%

A New Method for Identification of Traditional Chinese Medicine Constitutions Based on Data of Tongue features with Machine Learning

Zhao

Duan

Han

et al. 2022

Preprint

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Background: Different Traditional Chinese medicine (TCM) constitution types have different disease susceptibility and tendency, and TCM constitution identification is of great significance in TCM clinical practice. The TCM constitution identification method based on observation and consultation is subjective, and the objective identification technique opens up a new way to modernize TCM treatment. Our study aimed to build a TCM constitution identification model based on tongue feature data and machine learning algorithms, which provides a new fast and accurate method for TCM constitution identification.Methods: We use TFDA-1 tongue diagnostic instrument to collect standardized tongue images of people with Yang deficiency constitution, Yin deficiency constitution and balanced constitution. and use tongue image analysis software (TDAS) to quantitatively analyze tongue color, tongue texture and tongue coating area. Pearson correlation analysis was used to explore the correlation between tongue characteristics and TCM constitution. Four machine learning algorithms, including SVM, decision tree, random forest, and XGboost were used to build a TCM constitution identification model based on tongue features and evaluate the model's effectiveness.Results: The results show that XGboost has the highest accuracy rate among the four machine learning algorithms and the best performance in model evaluation. Pearson correlation analysis found a specific correlation between TCM constitution and tongue features. Significant correlations existed between the Yang deficiency constitution, Yin deficiency constitution, and the balanced constitution with 16 tongue features. In addition, the model's accuracy for the group 2 containing 16 tongue features was higher than that of the whole feature group (Group 1). XGboost was the most effective in this study for identifying TCM constitution, and the tongue features filtered by correlation analysis led to higher accuracy of TCM constitution identification.Conclusions: Tongue feature information can be an essential reference for TCM constitution identification. Machine learning provides a method for rapid identification of TCM constitution types. The XGboost TCM constitution identification model with good performance gives a new way for clinical " Identifying TCM Constitution by Tongue Image" implementation offers a reference and contributes to the performance of " Preventive Treatment of Disease" of TCM and individualized diagnosis and treatment and health preservation. In addition, Objective identification technology has opened up a new way to modernize TCM diagnosis and treatment.

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“…In addition, many studies have shown that the activity and expression of c-Abl are significantly increased in the brains of PD patients. Kinase blockers can improve brain function, reduce neuron death, inhibit CDK5 phosphorylation, regulate α-synuclein elimination, and inhibit Parkin phosphorylation [89][90][91][92][93]. In addition to animal experiments, clinical studies have also found that the treatment of patients with moderate or severe PD with nilotinib for 6 months can significantly alleviate cognitive symptoms [94].…”

Section: Roles Of C-abl Blockersmentioning

confidence: 99%

Roles for c-Abl in postoperative neurodegeneration

Feng¹,

Fu²,

Yao³

et al. 2022

Int. J. Med. Sci.

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The nonreceptor tyrosine kinase c-Abl is inactive under normal conditions. Upon activation, c-Abl regulates signaling pathways related to cytoskeletal reorganization. It plays a vital role in modulating cell protrusion, cell migration, morphogenesis, adhesion, endocytosis and phagocytosis. A large number of studies have also found that abnormally activated c-Abl plays an important role in a variety of pathologies, including various inflammatory diseases and neurodegenerative diseases. c-Abl also plays a crucial role in neurodevelopment and neurodegenerative diseases, mainly through mechanisms such as neuroinflammation, oxidative stress (OS), and Tau protein phosphorylation. Inhibiting expression or activity of this kinase has certain neuroprotective and anti-inflammatory effects and can also improve cognition and behavior. Blockers of this kinase may have good preventive and treatment effects on neurodegenerative diseases. Cognitive dysfunction after anesthesia is also closely related to the abovementioned mechanisms. We infer that alterations in the expression and activity of c-Abl may underlie postoperative cognitive dysfunction (POCD). This article summarizes the current understanding and research progress on the mechanisms by which c-Abl may be related to postoperative neurodegeneration.

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Relationships Between Traditional Chinese Medicine Constitution and Age-Related Cognitive Decline in Chinese Centenarians

Cited by 8 publications

References 23 publications

Care patterns and Traditional Chinese Medicine constitution as factors of depression and anxiety in patients with systemic sclerosis: A cross-sectional study during the COVID-19 pandemic

Care patterns and Traditional Chinese Medicine constitution as factors of depression and anxiety in patients with systemic sclerosis: A cross-sectional study during the COVID-19 pandemic

A New Method for Identification of Traditional Chinese Medicine Constitutions Based on Data of Tongue features with Machine Learning

Roles for c-Abl in postoperative neurodegeneration

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