Relationships Between Viral Load, Neuroimaging, and NP in Persons Living With HIV

Abstract

Background: This study examined whether recommended viral load (VL) classifications by the Department of Health and Human Services map onto changes in brain integrity observed in people living with HIV (PLWH).Methods: Three hundred forty-nine PLWH on combination antiretroviral therapy meeting criteria for virologic suppression (VS) (VL # 20 copies/mL; n = 206), "low-level viremia" (20-200 copies/mL; n = 63), or virologic failure (VF) (.200 copies/mL; n = 80) and 195 demographically similar HIV-negative controls were compared for cognition and brain volumes from 10 regions of interest that are sensitive to HIV. Changes in cognition and brain volumes were examined in a subset of PLWH (n = 132) who completed a follow-up evaluation (mean interval = 28 months) and had no change in treatment regimen.Results: Significant differences in cognition and brain volumes were observed between the HIV-negative control and VS groups compared with those in the VF groups, with few differences observed between the 3 PLWH subgroups. Longitudinally, PLWH who continued to have VF exhibited a greater decline in cognition and brain volumes compared with PLWH who remained with VS. Observed longitudinal changes in cognition correlated with brain volume changes. Conclusion:PLWH with continued VF (consecutive VL measurements of .200 copies/mL) represent a cause for clinical concern and may benefit from change in treatment in addition to consideration of other potential etiologies of VF to reduce loss of brain integrity.

In situ analysis of neuronal injury and neuroinflammation during HIV-1 infection

“…The establishment of the CNS as a HIV reservoir is highlighted by findings of virally suppressed PLWH with undetectable virus load in the blood, but detectable virus levels in the cerebrospinal fluid (CSF) [ 7 – 10 ] or viral DNA in post-mortem human brain tissue [ 11 , 12 ]. More importantly, low-level productive viral infection in the CNS contributes to brain volume changes and cognitive impairments in virally suppressed PLWH on cART compared to uninfected individuals [ 13 – 16 ].…”