Relationships between viscoelastic properties of lumbar intervertebral disc and degeneration grade assessed by MRI

Campana, S.; Charpail, E.; Guise, Jacques A. de; Rillardon, L.; Skalli, Wafa; Mitton, David

doi:10.1016/j.jmbbm.2011.01.007

Cited by 37 publications

(27 citation statements)

References 39 publications

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“…Preliminary in-vitro work has shown correlations between magnetic resonance images and disc mechanical properties (Campana et al, 2011;Cortes et al, 2014;Mwale et al, 2008;Périé et al, 2006;Recuerda et al, 2012), but in-vivo applications are still lacking. Moreover, cost and accessibility of magnetic resonance imaging represent an issue when considering large scale routine clinical use.…”

Section: Introductionmentioning

confidence: 99%

Non-invasive biomechanical characterization of intervertebral discs by shear wave ultrasound elastography: a feasibility study

et al. 2014

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Objectives: Although magnetic resonance is widely spread to qualitatively assess disc morphology, a simple method to reliably determine intervertebral disc status is still lacking. Shear wave elastography is a recent technique that allows quantitative evaluation of soft-tissues mechanical properties; the aim of this study was to preliminary assess the feasibility and reliability of cervical intervertebral disc mechanical characterization by elastography and to provide first reference values for asymptomatic subjects.Methods: Elastographic measurements were performed to determine shear wave speed (SWS) in C6-C7 or C7-T1 disc of forty-seven subjects; repeatability and inter-operator reproducibility were assessed.Results: Global average shear wave speed (SWS) was 3.0 ± 0.4 m/s; measurement repeatability and inter-user reproducibility were 7 and 10 %, respectively. SWS was correlated with both subject's age (p = 1.3e-5) and body mass index (p = 0.008).Conclusions: Shear wave elastography in intervertebral disc proved reliable and allowed stratification of subjects according to age and BMI. Applications could be relevant, for instance, in early detection of disc degeneration or in follow-up after trauma; these results open the way to larger cohort studies to define the place of this technique in routine intervertebral disc assessment.

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Section: Introductionmentioning

confidence: 99%

Non-invasive biomechanical characterization of intervertebral discs by shear wave ultrasound elastography: a feasibility study

et al. 2014

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“…More invasive measuring techniques are also being explored [23], but they can only be applied during surgery. Direct and non-invasive measurement techniques to assess spine flexibility are still lacking, although preliminary results have been reported in IVD mechanical characterization with magnetic resonance imaging [24][25][26][27].…”

Section: Introductionmentioning

confidence: 99%

Intervertebral disc characterization by shear wave elastography: An in vitro preliminary study

Vergari

Rouch

Dubois

et al. 2014

Proc Inst Mech Eng H

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Science Arts & Métiers (SAM)is an open access repository that collects the work of Arts et Métiers ParisTech researchers and makes it freely available over the web where possible. properties remains a challenge. Ultrasound elastography is a relatively recent measurement technique allowing the evaluation of soft tissue's elastic modulus through the measurement of shear wave speed (SWS). The aim of this study was to determine the feasibility of elastographic measurements in intervertebral disc (IVD). An in-vitro approach was chosen to test the hypothesis that SWS can be used to evaluate IVD mechanical properties and to assess measurement repeatability. Eleven oxtail IVDs were tested in compression to determine their stiffness and apparent elastic modulus at rest and at 400 N. Elastographic measurements were performed in these two conditions and compared to these mechanical parameters. The protocol was repeated six times to determine elastographic measurement repeatability. Average SWS over all samples was 5.3 ± 1.0 m/s, with a repeatability of 7 % at rest and 4.6 % at 400 N; stiffness and apparent elastic modulus were 266.3 ± 70.5 N/mm and 5.4 ± 1.1 MPa at rest, respectively, while at 400 N they were 781.0 ± 153.8 N/mm and 13.2 ± 2.4 MPa. Correlations were found between elastographic measurements and IVD mechanical properties; these preliminary results are promising for further in-vivo application.

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“…Employing the creep test in different imaging modalities like ultrasound [50, 51], MRI [53, 54] to evaluate the viscoelastic properties of the medium has been proposed by a number of investigators. For this purpose, compression devices have been designed for such imaging modalities [42, 53].…”

Section: Introductionmentioning

confidence: 99%

“…For this purpose, compression devices have been designed for such imaging modalities [42, 53]. Other investigators [54–61] have proposed various compression devices for elasticity imaging, where such devices are mainly designed for testing tissue at its rest position after the compression. Tissue compression has been also investigated in the context of poroelasticity [62–65].…”

Section: Introductionmentioning

confidence: 99%

Automated Compression Device for Viscoelasticity Imaging

Nabavizadeh

Kinnick

Bayat

et al. 2017

IEEE Trans. Biomed. Eng.

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Non-invasive measurement of tissue viscoelastic properties is gaining more attention for screening and diagnostic purposes. Recently, measuring dynamic response of tissue under a constant force has been studied for estimation of tissue viscoelastic properties in terms of retardation times. The essential part of such a test is an instrument that is capable of creating a controlled axial force and is suitable for clinical applications. Such a device should be lightweight, portable and easy to use for patient studies to capture tissue dynamics under external stress. In this paper we present the design of an automated compression device for studying the creep response of materials with tissue-like behaviors. The device can be used to apply a ramp-and-hold force excitation for a predetermined duration of time and it houses an ultrasound probe for monitoring the creep response of the underlying tissue. To validate the performance of the device, several creep tests were performed on tissue-mimicking phantoms and the results were compared against those from a commercial mechanical testing instrument. Using a second order Kelvin-Voigt model and surface measurement of the forces and displacements, retardation times T1 and T2 were estimated from each test. These tests showed strong agreement between our automated compression device and the commercial mechanical testing system, with an average relative error of 2.9% and 12.4 %, for T1 and T2 respectively. Also, we present the application of compression device to measure local retardation times for four different phantoms with different size and stiffness.

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Relationships between viscoelastic properties of lumbar intervertebral disc and degeneration grade assessed by MRI

Cited by 37 publications

References 39 publications

Non-invasive biomechanical characterization of intervertebral discs by shear wave ultrasound elastography: a feasibility study

Non-invasive biomechanical characterization of intervertebral discs by shear wave ultrasound elastography: a feasibility study

Intervertebral disc characterization by shear wave elastography: An in vitro preliminary study

Automated Compression Device for Viscoelasticity Imaging

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