Relationships of ABO and Rhesus blood groups with type 2 diabetes mellitus: a systematic review and meta-analysis

Getawa, Solomon; Bayleyegn, Biruk; Aynalem, Melak; Worku, Yilkal Belete; Adane, Tiruneh

doi:10.1177/03000605221129547

Cited by 9 publications

(8 citation statements)

References 51 publications

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“…This observation is consistent with the general population in which blood group O is associated with a lower risk of diabetes mellitus; on the other hand, patients with blood group B were at higher risk for diabetes mellitus. 11 Median follow-up was 8.8 years (0.1-46.9 years). There were 45 (14%) documented venous thrombotic events at or prior to ET diagnosis and 40 (12%) after diagnosis; the corresponding figures for arterial events were 55 (17%) and 67 (20%).…”

Section: Abo Blood Group Type and Risk Of Venous Thrombosis In Essent...mentioning

confidence: 99%

ABO blood group type and risk of venous thrombosis in essential thrombocythemia

et al. 2023

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Section: Abo Blood Group Type and Risk Of Venous Thrombosis In Essent...mentioning

confidence: 99%

ABO blood group type and risk of venous thrombosis in essential thrombocythemia

et al. 2023

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“…There were no additional eligible articles found by hand-checking the reference lists of all systematic reviews. Overall, 51 systematic reviews with meta-analyses corresponded to 270 unique associations were included [ 7 , 9 , 11 , 12 , 31 – 33 , 35 – 78 ] (Fig. 1 ).…”

Section: Resultsmentioning

confidence: 99%

ABO and Rhesus blood groups and multiple health outcomes: an umbrella review of systematic reviews with meta-analyses of observational studies

Liu,

Guo,

Xing

et al. 2024

BMC Med

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Background Numerous studies have been conducted to investigate the relationship between ABO and Rhesus (Rh) blood groups and various health outcomes. However, a comprehensive evaluation of the robustness of these associations is still lacking. Methods We searched PubMed, Web of Science, Embase, Scopus, Cochrane, and several regional databases from their inception until Feb 16, 2024, with the aim of identifying systematic reviews with meta-analyses of observational studies exploring associations between ABO and Rh blood groups and diverse health outcomes. For each association, we calculated the summary effect sizes, corresponding 95% confidence intervals, 95% prediction interval, heterogeneity, small-study effect, and evaluation of excess significance bias. The evidence was evaluated on a grading scale that ranged from convincing (Class I) to weak (Class IV). We assessed the certainty of evidence according to the Grading of Recommendations Assessment, Development, and Evaluation criteria (GRADE). We also evaluated the methodological quality of included studies using the A Measurement Tool to Assess Systematic Reviews (AMSTAR). AMSTAR contains 11 items, which were scored as high (8–11), moderate (4–7), and low (0–3) quality. We have gotten the registration for protocol on the PROSPERO database (CRD42023409547). Results The current umbrella review included 51 systematic reviews with meta-analysis articles with 270 associations. We re-calculated each association and found only one convincing evidence (Class I) for an association between blood group B and type 2 diabetes mellitus risk compared with the non-B blood group. It had a summary odds ratio of 1.28 (95% confidence interval: 1.17, 1.40), was supported by 6870 cases with small heterogeneity (I2 = 13%) and 95% prediction intervals excluding the null value, and without hints of small-study effects (P for Egger’s test > 0.10, but the largest study effect was not more conservative than the summary effect size) or excess of significance (P < 0.10, but the value of observed less than expected). And the article was demonstrated with high methodological quality using AMSTAR (score = 9). According to AMSTAR, 18, 32, and 11 studies were categorized as high, moderate, and low quality, respectively. Nine statistically significant associations reached moderate quality based on GRADE. Conclusions Our findings suggest a potential relationship between ABO and Rh blood groups and adverse health outcomes. Particularly the association between blood group B and type 2 diabetes mellitus risk.

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“…A total of ten pregnancy related diseases and complications were selected as outcomes for this study, including venous complications and hemorrhoids in pregnancy, gestational hypertension, pre-eclampsia, infections of genitourinary tract in pregnancy, gestational oedema and proteinuria without hypertension, preterm labor and delivery, spontaneous abortion, gestational diabetes mellitus (GDM), and other outcomes related to childbirth(Table S5). Type 2 diabetes (T2D) was selected as a positive control outcome since its association with protein level of ABO has already been confirmed (Table S6) [41]. To avoid sample overlap with pQTL GWAS, we obtained GWAS summary statistics (including estimates of regression coefficient, the corresponding standard error and P value, effect allele, other allele, and effect allele frequency) for all the outcomes from FinnGen [19].…”

Section: Genetic Associations Of Pregnancy Outcomesmentioning

confidence: 99%

The effect of protein levels of ABO on pregnancy related outcomes: a Mendelian randomization study

Sun,

Zheng,

Wang

et al. 2023

Preprint

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Protein level of Histo-Blood Group ABO System Transferase (ABO) has been reported to be associated with cardiometabolic diseases. But its effect on pregnancy related outcomes was still unclear. Here we conducted a two-sample Mendelian randomization study to ascertain the putative causal roles of protein levels of ABO in pregnancy related outcomes. Cis-acting protein quantitative trait loci (pQTLs) robustly associated with protein level of ABO (P<5x10-8) were used as instruments to proxy the ABO level (N=35,559, data from deCODE), with two additional pQTL datasets from Fenland (N=10,708) and INTERVAL (N=3,301) used as validation exposures. Ten pregnancy related diseases and complications were selected as outcomes. We observed that a higher protein level of ABO showed a putative causal effect on venous complications and haemorrhoids in pregnancy (OR=1.207, 95%CI=1.107-1.316, colocalization probability=91.3%), which was validated by using pQTLs from Fenland and INTERVAL. The Mendelian randomization results further showed effects of the ABO protein on gestational hypertension (OR=0.974, 95%CI=0.953-0.995), despite insignificance after multiple testing correction and little colocalization evidence. Sensitivity analyses, including proteome-wide Mendelian randomization of the cis-acting ABO pQTLs, showed little evidence of horizontal pleiotropy. Correctively, our study prioritised ABO as a putative causal protein for venous complications and haemorrhoids in pregnancy. Future epidemiology and clinical studies are needed to investigate whether ABO can be considered as a drug target to prevent adverse pregnancy outcomes.

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Relationships of ABO and Rhesus blood groups with type 2 diabetes mellitus: a systematic review and meta-analysis

Cited by 9 publications

References 51 publications

ABO blood group type and risk of venous thrombosis in essential thrombocythemia

ABO blood group type and risk of venous thrombosis in essential thrombocythemia

ABO and Rhesus blood groups and multiple health outcomes: an umbrella review of systematic reviews with meta-analyses of observational studies

The effect of protein levels of ABO on pregnancy related outcomes: a Mendelian randomization study

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