Relationships of Cervical, Thoracic, and Lumbar Bone Mineral Density by Quantitative CT

Weishaupt, Dominik; Schweitzer, Mark E.; DiCuccio, Michael; Whitley, Phillip E.

doi:10.1097/00004728-200101000-00027

Cited by 45 publications

(48 citation statements)

References 32 publications

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“…The question that arises is whether these densitometric data may be used for accurate BMD assessment. Preliminary studies have shown that high correlation between BMD, as determined with routine abdominal CT, versus lumbar QCT can be achieved [8][9][10].…”

Section: Introductionmentioning

confidence: 99%

Can abdominal multi-detector CT diagnose spinal osteoporosis?

et al. 2008

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The aim of this study was to (1) generate quantitative CT (QCT) densitometric data based on routine abdominal multi-detector (MDCT) examinations and (2) investigate whether these data can be used to differentiate osteoporotic from healthy females. Twenty-five female patients (group A) with a history of radiotherapy were examined both with routine abdominal MDCT and standard QCT to generate a MDCT-to-QCT conversion equation. Twenty-one osteoporotic (group B) and 23 healthy female patients (group C) were also recruited in the study. Patients of groups B and C underwent routine abdominal MDCT examination for various clinical indications. Mean bone mineral density (BMD) in patients of group A was 103.4 mg/ml +/- 32.8 with routine abdominal MDCT and 91.0 mg/ml +/- 28.5 with QCT. Quantitative CT BMD(QCT) values for patients in groups B and C were calculated utilizing the BMD(MDCT) values derived from routine abdominal MDCT data sets and the MDCT to QCT conversion equation: BMD(QCT)=0:78 x BMD(MDCT) + 10:13. The calculated QCT densitometric data adequately differentiated osteoporotic from healthy females (area under ROC curve 0.828, p = 0.05). In conclusion, this study showed that in a group of female patients, QCT data derived from routine abdominal MDCT examinations discriminated osteoporotic from healthy subjects.

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Section: Introductionmentioning

confidence: 99%

Can abdominal multi-detector CT diagnose spinal osteoporosis?

et al. 2008

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“…Yoganandan et al 12) reported that the mean BMD of the third cervical vertebra in young healthy adult female volunteers was 264.7 mg/ml. Also, Weishaupt et al 19) reported that the mean BMD of the second cervical vertebra in young healthy adult female volunteers was 297.2 mg/cm 3 . The mean BMD (255 mg/cm 3 HA) of the third cervical vertebra in the normal group of the study was Yoganandan et al 11) reported that the correlation coefficients between the BMDs of the cervical and lumbar vertebrae ranged from 0.615 to 0.757 in young healthy adult male volunteers.…”

Section: Discussionmentioning

confidence: 98%

“…The correlation coefficients in young healthy adult female volunteers ranged from 0.330 to 0.667, and the correlation coefficients of super-cervical vertebrae were lower than those of inferior cervical vertebrae 12) . Also, Weishaupt et al 19) reported that the correlation coefficient between the second cervical and fourth lumbar vertebrae in young healthy adult female volunteers was 0.379. In the present study of postmenopausal women, the correlation coefficient was 0.705, with the value being in the range of young healthy adult male volunteers 10) .…”

Section: Discussionmentioning

confidence: 98%

Relationship between Bone Mineral Densities of Cervical and Lumbar Vertebrae in Postmenopausal Women

Naitoh

Tamaki

Kurosu

et al. 2014

J. Hard Tissue Biology.

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For dental implant treatment, it is important to assess the general bone condition. Using multi-slice CT scans, we assessed the relationships between the bone mineral densities (BMDs) of the cervical and lumbar vertebrae in postmenopausal women to see if such data might be useful for imaging-based diagnosis prior to dental implant treatment. Thirty postmenopausal women were enrolled in this investigation, and their third cervical vertebrae were scanned for BMD using multi-slice computed tomography (CT) while the lumbar vertebrae were measured using dual energy X-ray absorptiometry, after which the percentage of the young adult mean (YAM) was calculated. The correlations between the BMD of the cervical vertebra and percentage of YAM were analyzed. The mean BMD of the cervical vertebra was 255 mg/cm 3 HA (s. : 35.9) in the osteoporosis group. A significant difference was observed between the normal and osteoporosis groups, and between the osteopenic and osteoporosis groups. A correlation (r = 0.705) was observed between the BMD of the cervical vertebrae and percentage of YAM of the lumbar vertebrae. The BMD of the third cervical vertebrae obtained from multi-slice CT images might be applicable in dental implant treatment to evaluate the influence of the general bone condition.

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“…Several studies have reported the differences in tBMD values throughout the lumbar, thoracic and cervical spine in human medicine. One study showed that mean tBMD values for women and men at the T12 vertebra (193.1/184.9 mg/cm 3 ) were higher than those at the L4 vertebra (186.2/180.1 mg/ cm 3 ) [28]. Another study revealed that the mean tBMD value at the T1 vertebra was higher than that at the L2 through L4 vertebrae in healthy female adults [29].…”

Section: Discussionmentioning

confidence: 99%

Assessment of Trabecular Bone Mineral Density Using Quantitative Computed Tomography in Normal Cats

Cheon

Choi

Lee

et al. 2012

The Journal of Veterinary Medical Science

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. The aim of this study was to assess age-related changes and anatomic variation in trabecular bone mineral density (tBMD) using quantitative computed tomography (QCT) in normal cats. Seventeen normal cats were included in this study and divided into the following 3 age groups:<6 months (n=4), 2-5 years (n=10) and >6 years (n=3). A computed tomographic scan of each vertebra from the 12th thoracic to the 7th lumbar spine and the pelvis was performed with a bone-density phantom (50, 100 and 150 mg/cm 3 , calcium hydroxyapatite, CIRS phantom ® ). On the central transverse section, the elliptical region of interest (ROI) was drawn to measure the mean Hounsfield unit (HU) value. Those values were converted to equivalent tBMD (mg/cm 3 ) by use of the bone-density phantom and linear regression analysis (r 2 >0.95). The mean tBMD value of the thoracic vertebrae (369.4 ± 31.8 mg/cm 3 ) was significantly higher than that of the lumbar vertebrae (285 ± 58.1 mg/cm 3 ). The maximum tBMD occurred at the T12, T13 and L1 levels in all age groups. There was a statistically significant difference in the mean tBMD value among the 3 age groups at the T12 (P<0.001), T13 (P<0.001) and L4 levels (P=0.013), respectively. The present study suggests that age-related changes and anatomic variation in tBMD values should be considered when assessing tBMD using QCT in cats with bone disorders. KEY WORDS: bone mineral density, feline, quantitative computed tomography, trabecular bone. doi: 10.1292/jvms.11-0579; J. Vet. Med. Sci. 74(11): 1461-1467, 2012 Bone mineral density (BMD) decreases in accordance with normal aging and metabolic or systemic disease. The turnover rates for cancellous bone are 4 to 8 times greater than for cortical bone, so cancellous bone is more sensitive to disease-induced changes [25]. Therefore, in humans with osteoporosis, BMD has been primarily investigated in cancellous bone.On the basis of this relationship, several techniques have been developed to noninvasively measure bone mineralization at various skeletal sites. These include radioabsorptiometry (RA), single photon absorptiometry (SPA), dual photon absorptiometry (DPA), quantitative ultrasound (QUS), dual-energy x-ray absorptiometry (DEXA), quantitative computed tomography (QCT) and peripheral QCT (pQCT). Among these, DEXA, QCT and pQCT have become the established methods for evaluating skeletal status, assessing osteoporosis, determining fracture risk and monitoring metabolic diseases and therapies in humans [8,[10][11][12][13].Feline diseases affecting BMD include mucopolysaccharidosis, osteopetrosis, osteogenesis imperfect and osteopenia related to primary hyperparathyroidism and secondary to renal or nutritional hyperparathyroidism. Reports in cats have been limited to the studies for BMD evaluation using DEXA [17] and a few peer-reviewed studies that measured BMD in clinically normal cats and abnormal cats using DEXA [3,23]. DEXA has been accepted as the gold standard method of BMD measurement, and it requires less X-ray exposure for the patient...

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Relationships of Cervical, Thoracic, and Lumbar Bone Mineral Density by Quantitative CT

Abstract: Trabecular BMD of C2 and C5 measured by QCT is significantly higher than trabecular BMD of T12 and L4 in nonosteoporotic volunteers of both genders.

Cited by 45 publications

References 32 publications

Can abdominal multi-detector CT diagnose spinal osteoporosis?

Can abdominal multi-detector CT diagnose spinal osteoporosis?

Relationship between Bone Mineral Densities of Cervical and Lumbar Vertebrae in Postmenopausal Women

Assessment of Trabecular Bone Mineral Density Using Quantitative Computed Tomography in Normal Cats

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