Relationships of Circadian Rhythms and Physical Activity With Objective Sleep Parameters in Lung Cancer Patients

Abstract

Adequate light-intensity physical activity can be an effective intervention to improve sleep quality in lung cancer patients.

Relationship between subjective and actigraphy-measured sleep in 237 patients with metastatic colorectal cancer

“…It is possible that the dichotomy index is a more sensitive marker of perceived sleep function because it takes both daytime and nighttime activity into account. [21; 22; 26] Indeed, patients who complained of poor sleep allegedly suffered from consequences of unrestful sleep during daytime, and the circadian rest-activity rhythm was reported as a correlate to fatigue,[8; 25] an expected repercussion of altered nighttime sleep. [38]…”

“…[22] In previous studies, I<O has been shown to be one of the most clinically relevant circadian parameters in terms of prognosis and correlation with health-related quality of life and symptoms. [18; 23–26]…”

Effect of walking on circadian rhythms and sleep quality of patients with lung cancer: a randomised controlled trial

“…Furthermore, sleep quality can be objectively assessed through actigraphy: sleep disturbance is indicated by a total sleep time (TST) of ⩽6.5 h (Lacks and Morin, 1992), sleep efficiency (SE) of ⩽85% (Coates et al , 1982), sleep onset latency (SOL) of >30 min (Espie et al , 2001), or wake after sleep onset (WASO) of >30 min (Savard and Morin, 2001). Factors including age (Kim et al , 2000; Chen et al , 2015b), sex, marital status (Baiden et al , 2015), cancer stage, and anticancer treatments (Roscoe et al , 2007; Chen et al , 2015b), which can affect sleep quality, must be included in sleep quality assessments for cancer patients. Unstable rest-activity rhythms lead to sleep disturbance (Miaskowski and Lee, 1999; Berger et al , 2007), and non-small-cell lung cancer patients with disrupted rest-activity rhythms may experience poor sleep quality and insomnia (Levin et al , 2005).…”

Physical Activity Modulates Common Neuroplasticity Substrates in Major Depressive and Bipolar Disorder

“…Supporting this notion is evidence that regular PA induces neurochemical changes that qualitatively and quantitatively improve sleep across patient populations [27–29, 368–372]. One RCT in sedentary adults with insomnia demonstrated that increasing PA to the level recommended in public health guidelines (≥150 min of moderate- to vigorous-intensity PA per week) improved sleep quality [28], whereas other studies demonstrated that adults who fail to achieve sufficient levels of PA incur sleep problems [372–375].…”

“…PA alters the progression of MD neuropathology by optimizing the levels of neurotransmitters [13], neurotrophic factors [13, 14], beta-endorphins [15], cortisol [16, 17], and muscle-derived protein (peroxisome proliferator-activated receptor gamma coactivator 1- α [PGC-1 α ]) [18]. Moreover, regular PA optimizes processes involved in neurogenesis [19, 20], immune function [21, 22], stress regulation [23, 24], antioxidant defense [25, 26], circadian rhythms [27–29], epigenetic modifications [30, 31], and the maintenance of telomere length [32–35]. …”