Relationships of urinary phyto‐oestrogen excretion to BMD in postmenopausal women

Kim, M. K.; Chung, Bong Chul; Yu, V. Y. H.; Nam, J. H.; Lee, H. C.; Huh, Kap Bum; Lim, Sung Kil

doi:10.1046/j.1365-2265.2002.01470.x

Cited by 64 publications

(33 citation statements)

References 30 publications

(112 reference statements)

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“…Of the studies reported, Chinese and Dutch women excreted higher amounts of urinary lignans (den Tonkelaar et al, 2001) whereas Asian populations in China (Roach et al, 1998;Dai et al, 2002) and Japan (Uehar et al, 2000;Arai et al, 2000) excreted higher amounts of isoflavones. Interestingly, urinary isoflavone concentrations in Korean women were similar to those in Americans (Kim et al, 2002). We report nationally representative urinary concentrations of phytoestrogens in the US population.…”

Section: Introductionmentioning

confidence: 58%

“…Through this mechanism and others, phytoestrogens are thought to protect against coronary heart disease ( Clarkson and Anthony, 1998;Cassidy and Griffin, 1999). Additionally, phytoestrogen consumption has been linked loosely with relief of menopausal symptoms such as hot flashes, although the validity of these data are under debate (Adlercreutz et al, 1992;Vincent and Firzpatrick, 2000;Kim et al, 2002;Kurzer, 2002).…”

Section: Introductionmentioning

confidence: 99%

“…Phytoestrogens have been measured in urine (Adlercreutz et al, 1986(Adlercreutz et al, , 1991(Adlercreutz et al, , 1995bHorn-Ross et al, 1997;Roach et al, 1998, Lampe et al, 1998Uehar et al, 2000;Dai et al, 2002;Kim et al, 2002;Valentı´n-Blasini et al, 2003); feces (Adlercreutz et al, 1995a); serum (Anderson et al, 1995;Stumpf et al, 2000;Morton et al, 2002 Figure 1. A schematic representation of the reported metabolism of isoflavones (a) and lignans (b).…”

Section: Introductionmentioning

confidence: 99%

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Urinary phytoestrogen concentrations in the U.S. population (1999–2000)

Valentín-Blasini

Sadowski

Walden

et al. 2005

J Expo Sci Environ Epidemiol

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We report population-based urinary concentrations of phytoestrogens stratified by age, sex, and composite racial/ethnic variables. We measured the isoflavones F genistein, daidzein, equol, and O-desmethylangolensin (O-DMA) F and the lignans F enterolactone and enterodiol F in approximately 2500 urine samples from individuals aged 6 years and older who participated in the National Health and Nutrition Examination Survey (NHANES) in 1999 and 2000. We detected all phytoestrogens in over 70% of the samples analyzed; enterolactone was detected in the highest concentrations, and daidzein was detected with the highest frequency. The geometric means for each phytoestrogen were as follows: genistein, 22.3 mg/g; daidzein, 68.6 mg/g; equol, 7.65 mg/g; O-DMA, 3.95 mg/g; enterolactone, 217 mg/g; and enterodiol, 24.3 mg/g creatinine. The 95th percentiles for each phytoestrogen were as follows: genistein, 380 mg/g; daidzein, 944 mg/g; equol, 50.3 mg/g; O-DMA, 217 mg/g; enterolactone, 2240 mg/g; and enterodiol, 240 mg/g creatinine. Multivariate analyses showed statistically significant differences among many of the demographic subgroups. Adolescents had higher concentrations of genistein and equol than adults. Non-Hispanic whites had higher concentrations of enterodiol and equol than Mexican Americans or non-Hispanic blacks. Non-Hispanic whites also had higher concentrations of enterolactone and O-DMA than Mexican Americans. Mexican Americans had higher concentrations of genistein than non-Hispanic blacks; however, the opposite was found for O-DMA. Determination of phytoestrogen exposure in the US population will help us to better understand phytoestrogen consumption in the US and will assist us in elucidating the potential role of phytoestrogens in protecting against cancer and heart disease.

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Section: Introductionmentioning

confidence: 58%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Urinary phytoestrogen concentrations in the U.S. population (1999–2000)

Valentín-Blasini

Sadowski

Walden

et al. 2005

J Expo Sci Environ Epidemiol

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“…Subsequently, bone density studies have investigated the correlation between endoc r i n e f u n c t i o n a n d b o n e m e t a b o l i s m i n w o m e n (Ongphiphadhanakul et al 2000;Kim et al 2002) and the correlation between physical exercise and bone metabolism (Akisaka et al 1997;Vincente-Rodriguesz et al 2008). However, these were group comparison studies, and very few reports have described the relationship between physical development and BMD in specific age groups.…”

Section: Discussionmentioning

confidence: 99%

Correlation of Body Growth and Bone Mineral Density Measured by Ultrasound Densitometry of the Calcaneus in Children and Adolescents

Nohara

Ueda²,

Ohta

et al. 2009

Tohoku J. Exp. Med.

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“…Most of the studies suggest that phytoestrogens are somewhat effective in maintaining BMD in postmenopausal women (58)(59)(60)(61)(62)(63)(64)(65). Moreover, recent results from the Women's Health Initiative Study, showing an unexpected lack of cardioprotective effects of HRT (22), pushed the research for alternative and natural strategies for managing and preventing osteoporosis.…”

Section: A Pharmacological Model: Phytoestrogens and Bone Healthmentioning

confidence: 99%

Phytoestrogens: Food or Drug?

Bacciottini¹,

Falchetti²,

Pampaloni³

et al. 2006

Postmenopausal Osteoporosis

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SummaryWithin the past several years, the relation between diet and health has been accepted by the mainstream nutrition community and in this connection interest in the physiological role of bioactive compounds present in plants has dramatically increased over the last decade. The phytoestrogens are bioactive molecules present as nutritional constituents of widely consumed vegetables. Their name derives from the fact that they are able to bind to estrogen receptors and to induce an estrogenic/antiestrogenic response in target tissues. Natural estrogens are involved in a multiplicity of programmed events in target tissues as uterus, breast, pituitary gland and hormone responsive tumors. Phytoestrogens are present in many human foodstuffs including fruits (plum, pear, apple grape berries, …), vegetables (beans, sprouts, cabbage, spinach, soybeans, grains, hops, garlic, onion,…), wine, tea, and they have been identified in a number of botanical dietary supplements. They include a wide variety of structurally different compounds such as isoflavones, mainly found in soy, lignans found in grains, stilbenes found in the skin of grapes. Other less investigated compounds include flavones, flavans, isoflavanes and coumestans. The estrogenic or antiestrogenic activity of any chemicals depends on the ability of the compound to interact with the ERs (ERα α, ERβ β). This article reported the knowledge about the activity of phytoestrogens from a pharmacological point of view for their estrogenicity or antiestrogenicity.

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Relationships of urinary phyto‐oestrogen excretion to BMD in postmenopausal women

Cited by 64 publications

References 30 publications

Urinary phytoestrogen concentrations in the U.S. population (1999–2000)

Urinary phytoestrogen concentrations in the U.S. population (1999–2000)

Correlation of Body Growth and Bone Mineral Density Measured by Ultrasound Densitometry of the Calcaneus in Children and Adolescents

Phytoestrogens: Food or Drug?

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