Relative and Combined Effects of Chronic Alcohol Consumption and HCV Infection on Serum Zinc, Copper, and Selenium

González‐Reimers, Emilio; Martín-González, M. Candelaria; Alemán-Valls, María Remedios; Vega-Prieto, Marı́a José de la; Galindo-Martín, L.; Abreu-González, Pedro; Santolaria-Fernández, Francisco

doi:10.1007/s12011-009-8399-5

Cited by 11 publications

(5 citation statements)

References 30 publications

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“…In addition to alcohol consumption, the relationship between serum copper levels (as well as zinc and selenium) and HCV infection was investigated in a paper by Gonzalez-Reimers et al (2009) [60]. In this research paper, no interaction was found between serum copper levels and alcohol consumption, but a direct relationship was confirmed between serum Cu levels and HCV infection.…”

Section: Copper Levels In Alcoholismmentioning

confidence: 93%

Serum iron, Magnesium, Copper, and Manganese Levels in Alcoholism: A Systematic Review

et al. 2019

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The aim of this paper was to review recent literature (from 2000 onwards) and summarize the newest findings on fluctuations in the concentration of some essential macro- and microelements in those patients with a history of chronic alcohol abuse. The focus was mainly on four elements which the authors found of particular interest: Iron, magnesium, copper, and manganese. After independently reviewing over 50 articles, the results were consistent with regard to iron and magnesium. On the other hand, data were limited, and in some cases contradictory, as far as copper and manganese were concerned. Iron overload and magnesium deficiency are two common results of an excessive and prolonged consumption of alcohol. An increase in the levels of iron can be seen both in the serum and within the cells, hepatocytes in particular. This is due to a number of factors: Increased ferritin levels, lower hepcidin levels, as well as some fluctuations in the concentration of the TfR receptor for transferrin, among others. Hypomagnesemia is universally observed among those suffering from alcoholism. Again, the causes for this are numerous and include malnutrition, drug abuse, respiratory alkalosis, and gastrointestinal problems, apart from the direct influence of excessive alcohol intake. Unfortunately, studies regarding the levels of both copper and manganese in the case of (alcoholic) liver disease are scarce and often contradictory. Still, the authors have attempted to summarize and give a thorough insight into the literature available, bearing in mind the difficulties involved in the studies. Frequent comorbidities and mutual relationships between the elements in question are just some of the complications in the study of this topic.

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Section: Copper Levels In Alcoholismmentioning

confidence: 93%

Serum iron, Magnesium, Copper, and Manganese Levels in Alcoholism: A Systematic Review

et al. 2019

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“…Included studies were conducted in Asia (19 studies), Africa (1 study), Europe (25 studies), and the USA (5 studies). On the other hand, according to the types of liver diseases, 7 were on fatty liver diseases [ 16 , 17 , 30 , 31 , 32 , 33 , 34 ], 22 on hepatitis [ 13 , 19 , 33 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 ], 32 on liver cirrhosis [ 13 , 30 , 31 , 33 , 35 , 36 , 37 , 38 , 39 , 41 , 42 , 44 , 48 , 50 , 52 , 54 , 55 , 56 , 57 , 58 , 59 , 60 ,…”

Section: Resultsmentioning

confidence: 99%

“…Included studies were conducted in Asia (19 studies), Africa (1 study), Europe (25 studies), and the USA (5 studies). On the other hand, according to the types of liver diseases, 7 were on fatty liver diseases [16,17,[30][31][32][33][34], 22 on hepatitis [13,19,33,[35][36][37][38][39][40][41][42][43][44][45][46][47][48][49][50][51][52][53], 32 on liver cirrhosis [13,30,31,33,[35][36][37][38][39]41,42,44,48,50,52,[54][55][56][57][58][59]…”

Section: Study Characteristicsmentioning

confidence: 99%

Selenium Status in Patients with Chronic Liver Disease: A Systematic Review and Meta-Analysis

Lin

Lian

et al. 2022

Nutrients

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Background: The potential role of selenium in preventing chronic liver diseases remains controversial. This meta-analysis aimed to summarize the available evidence from observational studies and intervention trials that had evaluated the associations between body selenium status and chronic liver diseases. Methods: We comprehensively searched MEDLINE, Embase, Web of Science, and Cochrane Library from inception to April 2021. The study protocol was registered at PROSPERO (CRD42020210144). Relative risks (RR) for the highest versus the lowest level of selenium and standard mean differences (SMD) with 95% confidence intervals (CI) were pooled using random-effects models. Heterogeneity and publication bias were evaluated using the I2 statistic and Egger’s regression test, respectively. Results: There were 50 studies with 9875 cases and 12975 population controls in the final analysis. Patients with hepatitis (SMD = −1.78, 95% CI: −2.22 to −1.34), liver cirrhosis (SMD = −2.06, 95% CI: −2.48 to −1.63), and liver cancer (SMD = −2.71, 95% CI: −3.31 to −2.11) had significantly lower selenium levels than controls, whereas there was no significant difference in patients with fatty liver diseases (SMD = 1.06, 95% CI: −1.78 to 3.89). Moreover, the meta-analysis showed that a higher selenium level was significantly associated with a 41% decrease in the incidence of significant advanced chronic liver diseases (RR = 0.59, 95% CI: 0.49 to 0.72). Conclusion: Our meta-analysis suggested that both body selenium status and selenium intake were negatively associated with hepatitis, cirrhosis, and liver cancer. However, the associations for fatty liver diseases were conflicting and need to be established in prospective trials.

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“…In addition, GPx activity is reduced along with selenium levels in CHC ( r = 0.374, p = 0.148), providing a possible mechanism by which CHC stimulates oxidative stress due to selenium deficiency [87]. While others have found no significant reduction in serum selenium in CHC patients [88], alcohol intake was a major confounding variable as it affects selenium levels [89].…”

Section: Seleniummentioning

confidence: 99%

The Role of Micronutrients in the Infection and Subsequent Response to Hepatitis C Virus

Gupta

Read

Shackel

et al. 2019

Cells

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Micronutrient deficiencies develop for a variety of reasons, whether geographic, socioeconomic, nutritional, or as a result of disease pathologies such as chronic viral infection. As micronutrients are essential for a strong immune response, deficiencies can significantly dampen both the innate and the adaptive arms of antiviral immunity. The innate immune response in particular is crucial to protect against hepatitis C virus (HCV), a hepatotropic virus that maintains chronic infection in up to 80% of individuals if left untreated. While many micronutrients are required for HCV replication, an overlapping group of micronutrients are also necessary to enact a potent immune response. As the liver is responsible for the storage and metabolism of many micronutrients, HCV persistence can influence the micronutrients’ steady state to benefit viral persistence both directly and by weakening the antiviral response. This review will focus on common micronutrients such as zinc, iron, copper, selenium, vitamin A, vitamin B12, vitamin D and vitamin E. We will explore their role in the pathogenesis of HCV infection and in the response to antiviral therapy. While chronic hepatitis C virus infection drives deficiencies in micronutrients such as zinc, selenium, vitamin A and B12, it also stimulates copper and iron excess; these micronutrients influence antioxidant, inflammatory and immune responses to HCV.

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Relative and Combined Effects of Chronic Alcohol Consumption and HCV Infection on Serum Zinc, Copper, and Selenium

Cited by 11 publications

References 30 publications

Serum iron, Magnesium, Copper, and Manganese Levels in Alcoholism: A Systematic Review

Serum iron, Magnesium, Copper, and Manganese Levels in Alcoholism: A Systematic Review

Selenium Status in Patients with Chronic Liver Disease: A Systematic Review and Meta-Analysis

The Role of Micronutrients in the Infection and Subsequent Response to Hepatitis C Virus

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