Relative Anti-inflammatory and Analgesic Activities of the Whole Fruit, Fruit Bark, Pulp and Seed of Lagenaria breviflora Roberty

Oridupa, Olayinka A.; Saba, Adebowale Benard

doi:10.3923/jpt.2012.288.297

Cited by 7 publications

(7 citation statements)

References 20 publications

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“…Circulating neutrophil increase is usually associated with inflammatory response and bacterial infection in the body [23]. L. breviflora has been reported to have both antiinflammatory and antibacterial effect [24,25], which have also reflected in this study. This effect is comparable to that observed in rats administered with hydrochlorothiazide.…”

Section: Discussionsupporting

confidence: 71%

“…This study is focused on assessing toxicity or adverse effects that may result from treatment of hypertension with the extracts of Lagenaria breviflora and Xanthosoma sagittifolium, locally recommended for management of hypertension. L. breviflora (Family Cucurbitaceae) is a medicinal plant known to possess potent antioxidant, antiinflammatory and analgesic activities [8,9,10]. It was reported to have haematopoietic and immunostimulatory effects [11,12].…”

Section: Introductionmentioning

confidence: 99%

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Haematological and Biochemical Changes Associated with Treatment of Experimentally-Induced Hypertensive Wistar Rats with Lagenaria breviflora Roberty Fruit or Xanthosoma sagittifolium Exell Corm

Oridupa

Ojojugbo

Ovwighose

2018

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Section: Discussionsupporting

confidence: 71%

Section: Introductionmentioning

confidence: 99%

Haematological and Biochemical Changes Associated with Treatment of Experimentally-Induced Hypertensive Wistar Rats with Lagenaria breviflora Roberty Fruit or Xanthosoma sagittifolium Exell Corm

Oridupa

Ojojugbo

Ovwighose

2018

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“…The name and accordingly the activity of cucurbitacins vary depending on the position of the double bonds, ketone groups, and hydroxyl groups in the main skeleton of the compound (Chen et al, 2005). As cucurbitacins have a wide variety of biological activities, cucurbitacin derivatives have been demonstrated to have mainly antitumor (Jing et al, 2020; Wang et al, 2021), antiproliferative (Marostica et al, 2015), analgesic (Oridupa et al, 2013), antipyretic (Agil et al, 1995), anti‐inflammatory (Peng et al, 2020), and hepatoprotective (El Naggar et al, 2015) effects. The present study is the first to show that CuI extracted from the E. elaterium plant inhibits hepatocellular carcinoma cell proliferation by affecting cancer‐associated JAK/STAT3 pathway, PI3K/Akt/mTOR signaling, and p38/ERK/JNK pathways.…”

Section: Discussionmentioning

confidence: 99%

Cucurbitacin I exhibits anticancer efficacy through induction of apoptosis and modulation of JAK / STAT3 , MAPK / ERK , and AKT / mTOR signaling pathways in HepG2 cell line

Üremiş

Uremis

Çiğremiş

et al. 2022

Journal of Food Biochemistry

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Hepatocellular carcinoma is a common cancer type, especially among men. Although cucurbitacin I (CuI), widely found in plants belonging to the Ecballium elaterium (E. L) plant family, has been shown to have antitumorigenic properties in many cancer types, its anticancer effect, molecular mechanism, and apoptotic effect mediated by signal pathways on hepatocellular carcinoma have not been fully clarified. In the present study, we investigated the anticancer effect of CuI treated at different doses on the HepG2 cell line and the underlying mechanism in vitro. High-purity CuI was obtained from the E. elaterium plant with the aid of HPLC. The effects of this substance on the viability of cells were studied by the MTT assay. The effects of CuI on cell cycle progression and apoptosis were studied with flow cytometry. DNA breaks were analyzed by the Comet assay method.The proteins and genes involved in the JAK/STAT3, MAPK/ERK, and AKT/mTOR signaling pathways were investigated using Western blot and qRT-PCR, respectively. The results of this study demonstrated that CuI significantly reduced HepG2 cell growth in vitro, induced antiproliferation, and G2/M phase of the cell cycle was interrupted. Practical applicationsCuI administration was shown to downregulate the levels of proteins in the PI3K/ AKT/mTOR, MAPK, and JAK2/STAT3 cascades in HepG2 cells. CuI also reduced the expression of MAPK, STAT3, mTOR, JAK2, and Akt genes in different concentrations.DNA breaks are formed as a result of this effect. CuI, by reducing cell proliferation and promoting apoptosis, was found to have potential as a chemotherapeutic agent of hepatocellular carcinoma.

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“…) is locally used for treatment of diseases of inflammatory origin and known to possess potent antioxidant, anti-inflammatory and analgesic properties [15,16,17]. It is reported to lower fertility in normal Wistar rats [18].…”

Section: Breviflora (Family Cucurbitaceaementioning

confidence: 99%

“…The tubers of X. sagittifolium was peeled, cut into pieces and air dried for one week. The dried plant materials were then soaked in methanol for 96 hours for extraction as described by Oridupa and Saba [17]. The extract was then filtered and concentrated using a rotary evaporator (BUCHI R-210, Switzerland).…”

Section: Plant Materials and Preparation Of Extractsmentioning

confidence: 99%

Changes in Sperm Morphology and Characteristics of Experimentally-induced Hypertensive Wistar Rats Treated with Lagenaria breviflora Roberty or Xanthosoma sagittifolium Exell

Oridupa

Aina

Lawal

et al. 2019

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Aims: This study was designed to evaluate the male reproductive toxicity that may accompany treatment of hypertension in Wistar rats with methanol extracts of whole fruit of Lagenaria breviflora Roberty or corm of Xanthosoma sagittifolium Schott. Place and Duration of Study: The study was carried out at the Animal House of the Department of Veterinary Pharmacology and Toxicology between November, 2016 and January, 2017. Methodology: Antihypertensive study was carried out in 40 adult male Wistar rats equally and randomly distributed into 8 groups. First group was normotensive rats administered with distilled water, while hypertension was induced in groups 2-7 intraperitoneal administration of DOCA-salt twice weekly and daily inclusion of 1% sodium chloride in drinking water. Group 2 was hypertensive but untreated rats. Two hypertensive groups were administered with Lisinopril (5 mg/70 kg) or Hydrochlorothiazide (12.5 mg/70 kg). Two hypertensive groups were assigned to each extract and these rats were administered with the extracts at doses of 100 or 200 mg/kg body weight. The rats were treated per os for 5 weeks and sacrificed at the end of this period. The testes were harvested and semen samples were obtained from the left cauda epididymis. Semen analysis were carried out to determine sperm morphology and characteristics. Results: Result showed 1 primary and 7 secondary sperm abnormality types were observed with a non-significant (p>0.05) increase in total abnormal sperm cells. Live/dead ratio and sperm volume were unchanged but, sperm motility and count were significantly (p<0.05) reduced. Conclusion: It was inferred from the study that hypertension in itself induced infertility and also treatment of the medical condition with the extracts of L. breviflora or X. sagittifolium did not reverse the infertility. Therefore, caution should be exercised when treating hypertension with these medicinal plants, particularly in male animals used for breeding.

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Relative Anti-inflammatory and Analgesic Activities of the Whole Fruit, Fruit Bark, Pulp and Seed of Lagenaria breviflora Roberty

Cited by 7 publications

References 20 publications

Haematological and Biochemical Changes Associated with Treatment of Experimentally-Induced Hypertensive Wistar Rats with Lagenaria breviflora Roberty Fruit or Xanthosoma sagittifolium Exell Corm

Haematological and Biochemical Changes Associated with Treatment of Experimentally-Induced Hypertensive Wistar Rats with Lagenaria breviflora Roberty Fruit or Xanthosoma sagittifolium Exell Corm

Cucurbitacin I exhibits anticancer efficacy through induction of apoptosis and modulation of JAK / STAT3 , MAPK / ERK , and AKT / mTOR signaling pathways in HepG2 cell line

Changes in Sperm Morphology and Characteristics of Experimentally-induced Hypertensive Wistar Rats Treated with Lagenaria breviflora Roberty or Xanthosoma sagittifolium Exell

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