Relative apical sparing of longitudinal strain using two-dimensional speckle-tracking echocardiography is both sensitive and specific for the diagnosis of cardiac amyloidosis

Phelan, Dermot; Collier, Patrick; Thavendiranathan, Paaladinesh; Popović, Zoran B.; Hanna, Mazen; Plana, Juan Carlos; Marwick, Thomas H.; Thomas, James D.

doi:10.1136/heartjnl-2012-302353

Cited by 766 publications

(625 citation statements)

References 20 publications

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“…El caso presentado evidencia un gradiente de strain longitudinal basal apical, siendo menor en los segmentos basales y medios y mayor en los segmentos apicales. Este fenómeno denominado preservación relativa del strain apical (PRSA), fue estudiado por Dermot Phelan y colaboradores 3 , estableciendo un adecuado rendimiento para diferenciar Amiloidosis cardíaca (independiente del subtipo) de otros tipos de hipertrofia del ventrículo izquierdo (miocardiopatía hipertrófica y estenosis aórtica) y su cálculo se resumen en la Figura 2. Se debe mencionar que este particular fenómeno de la preservación del strain apical en Amiloidosis cardíaca, también ha sido reproducido por strain mediante ecocardiografía 3D y por resonancia magnética de corazón 4 .…”

Section: Discussionunclassified

Hipertrofia ventricular izquierda con patrón de strain característico

et al. 2017

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Left ventricular hypertrophy with a characteristic strain patternA 68 year-old male, with no past medical history, presented progressive shortness of breath on exertion and leg edema during the previous year. Transthoracic echocardiography depicted; severe left ventricular hypertrophy with mild systolic dysfunction (LVEF 50% biplane Simpson's method), severe diastolic dysfunction and moderate left atrial enlargement. Left ventricular myocardial deformation imaging by two-dimensional speckle-tracking was paramount for elucidating the differential diagnosis.

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Section: Discussionunclassified

Hipertrofia ventricular izquierda con patrón de strain característico

et al. 2017

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“…Strain values for each wall at all levels were obtained and averaged to obtain the average strain of the septal, lateral, inferior and anterior walls. The apex-to-base gradient in RLS was examined using absolute strain values as well as a relative apical LS calculated as [16]: Relative apical LS = Average apical LS/(average basal LS + Average mid LS)…”

Section: Methodsmentioning

confidence: 99%

Changes in left ventricular global and regional longitudinal strain during right ventricular pacing

Algazzar¹,

Katta²,

Ahmed³

et al. 2016

ica

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Background:Our study aimed to demonstrate the short-term impacts of right ventricular apical pacing (RVAP) and right ventricular septal pacing (RVSP) on left ventricular (LV) regional longitudinal strain (RLS) and global longitudinal strain (GLS) in patients with preserved ejection fraction (EF). LV strain and functions may be altered by RVAP. RVSP might be a better alternative. The detrimental effect of right ventricular (RV) pacing may be mediated by regional LV impairment.

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“…GLS also provided incremental prognostic value over N-terminal of the prohormone brain natriuretic peptide (NT-proBNP), cardiac troponin and other clinical variables. 10,11 In addition, although currently at an experimental level, strain imaging may help to detect subclinical cardiac dysfunction, e.g. in patients with diabetes.…”

Section: Systolic Functionmentioning

confidence: 99%

Novel Imaging Techniques for Heart Failure

Melero-Ferrer

López‐Vilella

Morillas-Climent

et al. 2016

Cardiac Failure Review

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Heart failure (HF) is an epidemic with an increasing prevalence and an absolute mortality rate of approximately 50 % within 5 years of diagnosis. Imaging plays a main role in HF diagnosis, assessment of aetiology and treatment guidance. This article reviews current HF applications for all the available non-invasive imaging modalities: echocardiography, cardiovascular magnetic resonance (CMR), nuclear imaging-positron emission tomography (PET) and single-photon emission computed tomography (SPECT) and computed tomography (CT). Echocardiography, with its recent developments, such as 3D echo, is the main imaging test used in the evaluation of HF patients, given its availability and reliability in assessing cardiac structure and function. CMR allows the characterisation of myocardial tissue, in addition to providing information on the structure and cardiac function, so it is a great help in the determination of HF aetiology and may predict patient outcomes. Nuclear imaging can detect ischaemia and viability and can obtain additional prognostic data. Cardiac CT is EchocardiographyAlthough echocardiography is a relatively 'ancient' technique, its versatility makes it unique in the provision of volumes, function, haemodynamics or valvular regurgitation. In addition, because of its availability, safety and low cost, echocardiography is the first and most widely used test for the diagnosis, selection of appropriate treatment and prognosis of HF.1 Echocardiography is also the most used imaging method in the reassessment of HF patients. It remains unclear when to repeat echocardiographic exams, but it is deemed appropriate at least in patients with worsening symptoms. Systolic FunctionGlobal left ventricular (LV) function is of paramount importance regarding therapeutic decisions. Visual estimation of ejection fraction (EF), the Teichholz and Simpson methods, have been widely validated. 2,3However, in 2D imaging, because of its operator-dependent nature, repeated testing has a high probability of producing variable volume and EF results.The apparition of 3D fully sampled matrix transthoracic echocardiography has enabled easier acquisition of images, 4 simplifying its routinary application. There have been many studies comparing 2D and 3D echocardiography (2DE and 3DE) and a 'reference' standard (generally CMR). A recent meta-analysis of all 3DE studies evaluating LV volumes and EF demonstrated that 3DE generally underestimated volumes, but not as significantly as 2DE. There was also less variability than 2D compared with CMR.5 Nonetheless, 3DE echocardiography may be challenging and not practical in patients with low image quality (e.g. critical patients), in whom 2DE measures are more realiable. 3DE is also a less standardised techique than 2DE, and because of this reason most laboratories use the more universally applicable 2DE measurements in clinical practice. Only recently, large analyses of LV parameters using 3DE in large cohorts of healthy individuals have been published to establish race, age and gender-specific ...

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Relative apical sparing of longitudinal strain using two-dimensional speckle-tracking echocardiography is both sensitive and specific for the diagnosis of cardiac amyloidosis

Abstract: CA is characterised by regional variations in LS from base to apex. A relative 'apical sparing' pattern of LS is an easily recognisable, accurate and reproducible method of differentiating CA from other causes of LV hypertrophy.

Cited by 766 publications

References 20 publications

Hipertrofia ventricular izquierda con patrón de strain característico

Hipertrofia ventricular izquierda con patrón de strain característico

Changes in left ventricular global and regional longitudinal strain during right ventricular pacing

Novel Imaging Techniques for Heart Failure

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