Relative bioavailability of copper in a copperlysine complex for chicks and lambs

Pott, E. B.; Henry, P. R.; Ammerman, C. B.; Merritt, A. M.; Madison, J B; Miles, R. D.

doi:10.1016/0377-8401(94)90026-4

Cited by 15 publications

(6 citation statements)

References 11 publications

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“…Baker et al (1991) reported that a copper-lysine complex provided Cu only as efficiently as copper sulfate. Pott et al (1994) reported a relative Cu bioavailability of 99 for a copper-lysine complex compared to 100 for copper sulfate. Guo et al (2001a) compared five organic copper products to reagent grade copper sulfate in two separate Table 6: Multiple linear regression of tibia ash and log transformed liver Cu concentration copper regressed on added dietary copper gave estimated relative bioavailability values of 124±5.1, 122±5.3 and 111±6.0 for copper lysine, copper amino acid and copper proteinate C, respectively in experiment 1.…”

Section: Resultsmentioning

confidence: 99%

Evaluation of Mintrex® Copper as a Source of Copper in Broiler Diets

Wang¹,

Cerrate²,

Coto³

et al. 2007

International J. of Poultry Science

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This study was conducted to evaluate the bioavailability of an organic copper source, MINTREX ® Cu, compared with reagent grade Cu sulfate as a source of Cu in broiler diets. Nutritionally complete basal diets were supplemented with either copper sulfate or MINTREX Cu to provide diets with 0, 10, 25, 50, 125, 250 and 500 mg kgG of supplemental Cu. Fifty commercial broiler strain (Cobb 500) male chicks were 1 placed in each of 48 pens. Each diet (except for 500 mg kgG) was fed to four replicate pens. The 500 mg kgG 1 1 level was fed to two replicate pens for each source. There were two feeding phases including starter (0-21 d) and grower (21-35 d). At the end of each phase, birds were weighed by pens and two birds per pen (four birds per pen for the 500 mg kgG levels) were killed to take liver and tibia samples for analysis of Cu 1 concentration. Overall, there was no effect of Cu source or dietary Cu concentration on feed conversion or mortality. At 14 d the birds in the MINTREX treatment weighed significantly more than the birds in the Cu sulfate treatment. High Cu concentrations markedly decreased (p<0.0001) body weight regardless of Cu sources in both phases. Elevated dietary Cu concentration significantly increased (p<0.01) tibia ash Cu concentration for both Cu sources in both phases; however there was no good linear relationship between tibia Cu accumulation and non-zero Cu consumption. There were marked effects (p<0.05) of Cu source, concentration and their interaction on 14 d dry liver Cu concentration. Based on dry liver Cu concentration regressed on non-zero copper consumption, the relative bioavailability of MINTREX Cu was 111.63% for 14 d and 110.71% for 35 d when bioavailability of reagent grade Cu sulfate was set as 100%. This indicated that MINTREX Cu source has greater biological availability than reagent grade Cu sulfate for broilers.

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Section: Resultsmentioning

confidence: 99%

Evaluation of Mintrex® Copper as a Source of Copper in Broiler Diets

Wang¹,

Cerrate²,

Coto³

et al. 2007

International J. of Poultry Science

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“…4 Considering Cu, amino acid complexes of Cu are widely used in animal nutrition and it has been shown that copper-lysine was as effective as sulfate in chicks, but its availability was only two-thirds of the inorganic salt in lambs. 5 As for Zn, its availability from a Zn-amino acid complex for pigs and Zn-methionine for chicks was not significantly different from that of inorganic sources. 6,7 However, Wedekind et al reported that the availability of organic Zn could be greater than Zn sulfate.…”

Section: Introductionmentioning

confidence: 83%

“…The higher bioavailability of Mn from Mn proteinate than from MnO and MnSO 4 suggests that chelate is the preferred chemical form for intestinal absorption 4 . Considering Cu, amino acid complexes of Cu are widely used in animal nutrition and it has been shown that copper–lysine was as effective as sulfate in chicks, but its availability was only two‐thirds of the inorganic salt in lambs 5 . As for Zn, its availability from a Zn–amino acid complex for pigs and Zn–methionine for chicks was not significantly different from that of inorganic sources 6,7 .…”

Section: Introductionmentioning

confidence: 99%

Bioavailability and tissue distribution of amino acid-chelated trace elements in rainbow trout Oncorhynchus mykiss

et al. 2003

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Feeding trials were conducted to determine the availability of amino acid‐chelated trace elements to rainbow trout. Three practical diets were supplemented with trace element mix either all from sulfates (Tr‐Sf), Zn and Mn from sulfates added with Cu from amino acid chelates (Cu‐Am) or a mixture of trace elements from amino acid chelates (Tr‐Am). Rainbow trout weighing 1.11 g were fed the experimental diets for 15 weeks. Growth, feed gain ratio (FGR), tissue distribution, retention of the elements and plasma alkaline phosphatase (ALP) activity were compared between the treatments. Absorption of the elements was determined using larger fish of approximately 95 g fed the same experimental diets. Growth and FGR were not significantly influenced by the chemical form of the elements. The highest concentration of Cu was measured in the liver, whereas highest concentrations of Zn and Mn were in bone. Plasma ALP activity was significantly higher in the Tr‐Am group. The absorption of elements from the Tr‐Am diet was higher but not significantly different from the other two diets. These results suggest that trace elements from Tr‐Am seem to be more available than from inorganic sources tested.

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“…However, Pott et al. () reported a relative copper bioavailability of Cu‐Lys for lambs of 68% compared with copper sulphate.…”

Section: Assessmentmentioning

confidence: 99%

Revision of the currently authorised maximum copper content in complete feed

2016

EFS2

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The Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) reviewed (i) the copper requirements of food-producing and pet animals, (ii) the copper concentration in feed materials and complete feed, (iii) the copper bioavailability, and (iv) the calculated background copper concentration of complete feed. Also considered were (i) the influence of dietary copper on gut microbiota profile and on the bacterial antibiotic resistance in target animals and (ii) the environmental occurrence of bacterial heavy metal tolerance (copper resistance) and resistance to certain antibiotics. The data collected supported the possibility of a reduction in some of the currently authorised maximum contents (CAMC) for total copper in feed. The EFSA Panel developed an algorithm to derive newly proposed maximum contents (NPMC) from the requirement and the native dietary copper content. The NPMC (mg Cu/kg complete feed) comprised of maintained (m), decreased (d) and increased (i) values: 15 for bovine before the start of rumination (m), 30 for other bovine (d), 35 for caprine (i), 15 for ovine (m), 50 for crustacean (m) and 25 for other animal species ((d) for piglets up to 12 weeks, (m) for all other species). The NMPC support health, welfare and economic productivity of target animals, except piglets; performance of weaned piglets would be impacted. The NPMC values would not likely have any consequences on the consumers' intake of copper and are of no concern for the safety of the consumer. The reduction from 170 mg to 25 mg Cu/kg feed piglets would have the capacity to save 1,200 tonnes copper/year being spread in the field and thus, to reduce total copper emissions from farm animal production by about 20%. Thus, the reduction of the CAMC to the NPMC would have a significant impact on the concentrations of copper in the environment of piggeries.

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Relative bioavailability of copper in a copperlysine complex for chicks and lambs

Cited by 15 publications

References 11 publications

Evaluation of Mintrex® Copper as a Source of Copper in Broiler Diets

Evaluation of Mintrex® Copper as a Source of Copper in Broiler Diets

Bioavailability and tissue distribution of amino acid-chelated trace elements in rainbow trout Oncorhynchus mykiss

Revision of the currently authorised maximum copper content in complete feed

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