Relative bioavailability of dl-methionine compared with l-methionine fed to nursery pigs

Kong, Changsu; Park, C.S.; Ahn, Jong Young; Kim, Beob Gyun

doi:10.1016/j.anifeedsci.2016.03.011

Cited by 16 publications

(11 citation statements)

References 12 publications

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“…All D -Met can be converted to L -Met by pigs (Kong, Park, Ahn, & Kim, 2016;Wretlind & Rose, 1950), because the capacity of the ratelimiting enzyme D -amino acid oxidase ( D -AAOX) to convert D -Met to L -Met is present in different tissues including liver, kidney, stomach, duodenum, jejunum and ileum (Fang et al, 2010). Indeed, several studies have reported that the pigs fed diets supplemented with L -Met had no differences in growth performance when compared with the pigs fed with DL -Met-supplemented diets (Chen, Piao, Zhao, & Zeng, 2013;Chung & Baker, 1992;Htoo & Morales, 2016;Kong et al, 2016;Tian, Zeng, Zhang, Long, & Piao, 2016 (Han et al, 2013;Wang et al, 2005;Xu, Mellor, Birtles, Reynolds, & Simpson, 1994). Shorter villus can lead to poor nutrient absorption, resulting in a lower utilization of nutrients (Li et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

Effects of dietary methionine supplementation on growth performance, intestinal morphology, antioxidant capacity and immune function in intra‐uterine growth‐retarded suckling piglets

Zhang

Chen

et al. 2019

Animal Physiology Nutrition

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This study investigated the effects of dietary supplementation with L‐methionine (L‐Met), DL‐methionine (DL‐Met) and calcium salt of the methionine hydroxyl analog (MHA‐Ca) on growth performance, intestinal morphology, antioxidant capacity and immune function in intra‐uterine growth‐retarded (IUGR) suckling piglets. Six normal birthweight (NBW) female piglets and 24 same‐sex IUGR piglets were selected at birth. Piglets were fed nutrient adequate basal diet supplemented with 0.08% L‐alanine (NBW‐CON), 0.08% L‐alanine (IUGR‐CON), 0.12% L‐Met (IUGR‐LM), 0.12% DL‐Met (IUGR‐DLM) and 0.16% MHA‐Ca (IUGR‐MHA‐Ca) from 7 to 21 days of age respectively (n = 6). The results indicated that IUGR decreased average daily milk (dry matter) intake and average daily gain and increased feed conversion ratio of suckling piglets (p < 0.05). Compared with the NBW‐CON piglets, IUGR also impaired villus morphology and reduced antioxidant capacity and immune homeostasis in the intestine of IUGR‐CON piglets (p < 0.05). Supplementation with L‐Met enhanced jejunal villus height (VH) and villus area and ileal VH of IUGR piglets compared with IUGR‐CON piglets (p < 0.05). Similarly, DL‐Met supplementation increased VH and the ratio of VH to crypt depth in the jejunum compared with IUGR‐CON pigs (p < 0.05). Supplementation with L‐Met and DL‐Met (0.12%) tended to increase reduced glutathione content and reduced glutathione: oxidized glutathione ratio and decrease protein carbonyl concentration in the jejunum of piglets when compared with the IUGR‐CON group (p < 0.10). However, supplementation with MHA‐Ca had no effect on the intestinal redox status of IUGR piglets (p > 0.10). In conclusion, supplementation with either L‐Met or DL‐Met has a beneficial effect on the intestinal morphology and antioxidant capacity of IUGR suckling piglets.

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Section: Discussionmentioning

confidence: 99%

Effects of dietary methionine supplementation on growth performance, intestinal morphology, antioxidant capacity and immune function in intra‐uterine growth‐retarded suckling piglets

Zhang

Chen

et al. 2019

Animal Physiology Nutrition

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“…The outcomes obtained from the current research TSAA clearly indicate that the range among the ratios were indeed sufficient to induce a response, which in turn allowed fitting statistical models to collected performance data which allowed estimating ideal Met:Cys/TSAA ratio for broilers. Graber and Baker [ 30 ] highlight that the complexity of determining nutrient requirements relies on the difference in the estimates produced from statistical models. With a considerable range in the dose of a nutrient, broiler responses exhibit different phases: an increase in response, a plateau phase, and a decrease in performance, which in some cases are associated with incidence of mortality if the dose administrated exceeds the toxicity tolerance of the organism [ 31 ].…”

Section: Discussionmentioning

confidence: 99%

Methionine to cystine ratio in the total sulfur amino acid requirements and sulfur amino acid metabolism using labelled amino acid approach for broilers

et al. 2018

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BackgroundAssuming that part of Methionine (Met) is converted into Cystine (Cys), but ignoring the rates with which such phenomenon occurs may lead to an excessive supply of Met in poultry diets. Such inconvenient could be easily avoided with the knowledge of the ideal Met:Cys/Total sulfur amino acids (TSAA) ratio and the rates of Met conversion into Cys.ResultsMet sources did not affect performance. Met:Cys/TSAA ideal ratio was determined using curvilinear-plateau regression model. Both optimum body weight gain and feed conversion ratio were estimated in 1007 g/day and 1.49, respectively, at 52% Met/TSAA ratio. Feed intake was not affected by Met:Cys/TSAA ratios. In the labelled amino acid assay, the rates with which Met was converted into Cys ranged from 27 to 43% in response to changes in Met:Cys/TSAA ratios, being higher at 56:44.ConclusionBased on performance outcomes, the minimum concentration of Met relative to Cys in diets for broilers from 14 to 28 d of age based on a TSAA basis, is 52% (52:48 Met:Cys/TSAA). The outcomes from labelled amino acid assay indicate that highest the Met supply in diets, the highest is its conversion into Cys.

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“…Considerable controversies had been surrounding the bioefficacy between DL-Met and L-Met in pigs. Kong et al (2016) reported that the estimates of RBA of DL-Met to L-Met were 87.9 and 89.3% in nursery pigs, respectively, using retained nitrogen and retention of nitrogen as dependent variables and supplemental Met isomers as independent variable. When ADG was used as the response criterion, the RBA was estimated at 99.6% for L-Met to DL-Met in weaned pigs (Htoo and Morales 2016).…”

Section: Growth Performancementioning

confidence: 99%

Bioavailability ofl-methionine relative todl-methionine in Broiler chickens

Wang

et al. 2019

Italian Journal of Animal Science

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This study was aimed to estimate the relative bioavailability (RBA) of L-methionine (L-Met) to DLmethionine (DL-Met) in broiler chickens from 1 to 21 d of age. A total of 1664 one-day-old broiler chicks were randomly divided into 13 groups with 8 replicates per group. The basal diet contained 60% of the NRC requirement for Met. Birds in treatment groups were fed the basal diet supplemented with graded levels of DL-or L-Met, resulting in the dietary content of Met at 75%, 80%, 85%, 90%, 95% and 100% of the NRC requirement, respectively. Results showed that there were linear increases (p < .05) in average daily gain (ADG), average daily feed intake, feed efficiency (FE), eviscerated weight, breast muscle weight and leg muscle weight in response to the increasing supplementation of either DL-or L-Met, which also linearly reduced (p < .05) plasma uric acid and protein carbonyl contents. Compared with DL-Met, L-Met addition resulted in elevations (p < .05) in ADG and FE, along with leg muscle yield of birds. A lower (p < .05) content of urea nitrogen with a higher (p < .05) content of uric acid in plasma were observed in the birds supplemented with L-Met compared with DL-Met. Slope-ratio assay revealed that the RBA of L-Met to DL-Met for ADG and FE were 141.5% and 189.1%, respectively. And the respective values were calculated as 122.9% and 116.8% when based on eviscerated weight and breast muscle weight as the response criteria. However, the above RBA estimates except for FE did not differ from 100%. Collectively, supplemental L-Met had a higher bioavailability for FE of broilers relative to DL-Met during the first 3 weeks of life. HIGHLIGHTS L-methionine addition has an advantage over DL-methionine for supporting the growth performance of broiler chickens in early age. The relative bioavailability of L-Met to DL-Met for feed efficiency of broiler chickens during the first 21 days post-hatch was calculated as 189.1% that differs from 100%.

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Relative bioavailability of dl-methionine compared with l-methionine fed to nursery pigs

Cited by 16 publications

References 12 publications

Effects of dietary methionine supplementation on growth performance, intestinal morphology, antioxidant capacity and immune function in intra‐uterine growth‐retarded suckling piglets

Effects of dietary methionine supplementation on growth performance, intestinal morphology, antioxidant capacity and immune function in intra‐uterine growth‐retarded suckling piglets

Methionine to cystine ratio in the total sulfur amino acid requirements and sulfur amino acid metabolism using labelled amino acid approach for broilers

Bioavailability ofl-methionine relative todl-methionine in Broiler chickens

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