Relative bioavailability of selenium in rice using a rat model and its application to human health risk assessment

Qin, Yan; Huang, Caicheng; Huang, Guirong; Li, Hong; Shohag, M.J.I.; Gu, Minghua; Shen, Fangke; Lu, Dan; Zhang, Mingfu; Wei, Yanyan

doi:10.1016/j.envpol.2023.122675

Cited by 34 publications

(5 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…To provide the risk index or calculate the probability of a certain populace developing cancer of any kind after being exposed to a carcinogen over a projected lifetime, the carcinogenic risk assessment is carried out 24 , 37 . The incremental lifetime cancer risk (ILCR) that projects the likelihood of an exposed individual person developing malignant cells over some time is evaluated using Eq.…”

Section: Methodsmentioning

confidence: 99%

Potentially toxic metals in irrigation water, soil, and vegetables and their health risks using Monte Carlo models

Orosun,

Nwabachili,

Alshehri

et al. 2023

Sci Rep

View full text Add to dashboard Cite

Food safety has become a serious global concern because of the accumulation of potentially toxic metals (PTMs) in crops cultivated on contaminated agricultural soils. Amongst these toxic elements, arsenic (As), cadmium (Cd), chromium (Cr), and lead (Pb) receive worldwide attention because of their ability to cause deleterious health effects. Thus, an assessment of these toxic metals in the soils, irrigation waters, and the most widely consumed vegetables in Nigeria; Spinach (Amaranthushybridus), and Cabbage (Brassica oleracea) was evaluated using inductively coupled plasma-optical emission spectroscopy (ICP-OES). The mean concentration (measured in mg kg−1) of the PTMs in the soils was in the sequence Cr (81.77) > Pb(19.91) > As(13.23) > Cd(3.25), exceeding the WHO recommended values in all cases. This contamination was corroborated by the pollution evaluation indices. The concentrations (measured in mg l−1) of the PTMs in the irrigation water followed a similar pattern i.e. Cr(1.87) > Pb(1.65) > As(0.85) > Cd(0.20). All the PTMs being studied, were found in the vegetables with Cr (5.37 and 5.88) having the highest concentration, followed by Pb (3.57 and 4.33), and As (1.09 and 1.67), while Cd (0.48 and 1.04) had the lowest concentration (all measured in mg kg−1) for cabbage and spinach, respectively. The concentration of the toxic metals was higher in spinach than in cabbage, which may be due to the redistribution of the greater proportion of the metals above the ground tissue, caused by the bioavailability of metals in the aqueous phase. Expectedly, the hazard index (HI),and carcinogenic risk values of spinach were higher than that of cabbage. This implies that spinach poses potentially higher health risks. Similarly, the Monte Carlo simulation results reveal that the 5th percentile, 95th percentile, and 50th percentile of the cumulative probability of cancer risks due to the consumption of these vegetables exceeds the acceptable range of 1.00E−6 and 1.00E−4. Thus, the probable risk of a cancerous effect is high, and necessary remedial actions are recommended.

show abstract

Section: Methodsmentioning

confidence: 99%

Potentially toxic metals in irrigation water, soil, and vegetables and their health risks using Monte Carlo models

Orosun,

Nwabachili,

Alshehri

et al. 2023

Sci Rep

View full text Add to dashboard Cite

show abstract

“…In the present study, HRI values were found greater than 1 for As, Pb, and Cd. while for Mn, Fe, and Zn HRI was found less than 1 except Zn which has HRI > 1 in point D. HRI less than 1 means the exposed population has no noticeable adverse health effects, whereas HRI greater than 1 means that there is a risk of non-carcinogenic effects, with an increasing probability as the value increases 76 , 77 . The high HRI values result from the high EDI of the metals involved.…”

Section: Discussionmentioning

confidence: 88%

The detrimental effects of heavy metals on tributaries exert pressure on water quality, Crossocheilus aplocheilus, and the well-being of human health

Subhanullah,

Hassan,

Ali

et al. 2024

Sci Rep

View full text Add to dashboard Cite

The escalating presence of heavy metals (HMs) in the Panjkora River water and their impact on fish pose a significant challenge to both the ecological community and human health. Consequently, a study was conducted with the primary aim of elucidating their influence on human health-related issues. To address this, the concentrations of heavy metals, including arsenic (As), cadmium (Cd), iron (Fe), manganese (Mn), lead (Pb), and zinc (Zn), in both water and the fish species Crossocheilus diplocheilus were investigated across various locations within the study area. The quantification of HMs concentration was carried out utilizing an atomic absorption spectrophotometer. The highest concentration in water was found as 0.060 mg/L for Pb and lowest for Fe, whereas the highest concentration in fish was 2.028 mg/kg for Pb and lowest for As. Human health risk associated with fish eating was evaluated by using health risk indices (HRI) for non-carcinogenic health risks and targeted cancer risk (TR) for carcinogenic health risks. The values of the health risk index (HRI) were found greater than 1 except Fe (0.0792), Zn (0.782), and Mn (0.541). The highest mean HRI > 1 was recorded for As (62.99), Cd (26.85), and Pb (10.56). This implies that fish consumption from river Panjkora is not safe up to some extent. Similarly, the TR value for As, Cd, and Pb was found 2.8 $$\times {10}^{-2}$$ × 10 - 2 , 1.6 $$\times {10}^{-2}$$ × 10 - 2 , 2.8 ×$${10}^{-3}$$ 10 - 3 which showed cancer risk. There is a detected risk to human health associated with the consumption of fish from the Panjkora River. The government must implement adaptive measures to address this significant issue of water pollution in the study area. Additionally, there is a need for further extensive and prolonged research studies in this context.

show abstract

“…The average global rice intake is 148 g/capita/day, demonstrating that consuming rice amended with Se 0 NMs can increase Se intake by 19.24 μg per day when compared to untreated rice. The overall intake of 69.56 μg is significantly less than the WHO daily upper tolerable dosage of 400 μg for adults . The significant increases in rice grain Se contents by the foliar application of Se 0 NMs could facilitate the intake of adequate nutrition for a daily human daily diet.…”

Section: Resultsmentioning

confidence: 99%

Selenium Nanomaterials Enhance Sheath Blight Resistance and Nutritional Quality of Rice: Mechanisms of Action and Human Health Benefit

Chen,

Jiang,

Wang

et al. 2024

ACS Nano

View full text Add to dashboard Cite

In the current work, the foliar application of selenium nanomaterials (Se 0 NMs) suppressed sheath blight in rice (Oryza sativa). The beneficial effects were nanoscale specific and concentration dependent. Specifically, foliar amendment of 5 mg/L Se 0 NMs decreased the disease severity by 68.8% in Rhizoctonia solani-infected rice; this level of control was 1.57-and 2.20-fold greater than that of the Se ions with equivalent Se mass and a commercially available pesticide (Thifluzamide). Mechanistically, (1) the controlled release ability of Se 0 NMs enabled a wider safe concentration range and greater bioavailability to Se 0 NMs, and (2) transcriptomic and metabolomic analyses demonstrated that Se 0 NMs simultaneously promoted the salicylic acid-and jasmonic-aciddependent acquired disease resistance pathways, antioxidative system, and flavonoid biosynthesis. Additionally, Se 0 NMs improved rice yield by 31.1%, increased the nutritional quality by 6.4−7.2%, enhanced organic Se content by 44.8%, and decreased arsenic and cadmium contents by 38.7 and 42.1%, respectively, in grains as compared with infected controls. Human simulated gastrointestinal tract model results showed that the application of Se 0 NMs enhanced the bioaccessibility of Se in grains by 22.0% and decreased the bioaccessibility of As and Cd in grains by 20.3 and 13.4%, respectively. These findings demonstrate that Se 0 NMs can serve as an effective and sustainable strategy to increase food quality and security.

show abstract

Relative bioavailability of selenium in rice using a rat model and its application to human health risk assessment

Cited by 34 publications

References 48 publications

Potentially toxic metals in irrigation water, soil, and vegetables and their health risks using Monte Carlo models

Potentially toxic metals in irrigation water, soil, and vegetables and their health risks using Monte Carlo models

The detrimental effects of heavy metals on tributaries exert pressure on water quality, Crossocheilus aplocheilus, and the well-being of human health

Selenium Nanomaterials Enhance Sheath Blight Resistance and Nutritional Quality of Rice: Mechanisms of Action and Human Health Benefit

Contact Info

Product

Resources

About