Relative biological effectiveness of photon energies used in brachytherapy and intraoperative radiotherapy techniques for two breast cancer cell lines

Marthinsen, Anne Beate Langeland; Gisetstad, Ragnhild; Danielsen, Signe; Frengen, Jomar; Strickert, Trond; Lundgren, Steinar

doi:10.3109/0284186x.2010.504226

Cited by 22 publications

(26 citation statements)

References 24 publications

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“…The Intrabeam system, a new mobileIORT system, has several advantages over brachytherapy and IOERT.Firstly, the relative biological effectiveness of the Intrabeamsystem's low-energy X-rays is higher than 192-Ir. [8] Secondly, the Intrabeam system's radiationdose is limited to a small volume, due to the X-rays' rapid dosefall-off of 50 kv, which protects normal surrounding tissue.Thirdly, the Intrabeam system can be administered in a standardoperating room and moved between different operating rooms, whichis not possible during IOERT. Finally, the X-ray source of theIntrabeam system is placed in a mobile arm, which holds theapplicator in the desired position.…”

Section: Discussionmentioning

confidence: 99%

Feasibility of intraoperative radiotherapy with X-rays for the treatment of superior sulcus tumours

Pan

Yang

Chen

et al. 2020

Preprint

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Background Preoperative concurrent chemoradiotherapy (CCRT) followed by surgery has become the standard treatment for potentially resectable superior sulcus (SS) tumours. To date, intraoperative radiotherapy (IORT) for SS tumour treatment is primarily performed via brachytherapy; it achieves high local control, but has no influence on overall survival. Therefore, a novel therapy is required to increase the local control of SS tumours. The purpose of this study was to evaluate the feasibility and safety of IORT with low-energy X-rays for treating SS tumours. Methods Patients diagnosed with stage IIB-IIIA SS tumours with chest wall invasion and scheduled to undergo surgery were eligible for this prospective pilot study. Every patient was discussed at a lung cancer multidisciplinary team meeting. Patients with potentially resectable tumour were scheduled for neoadjuvant chemoradiotherapy followed by surgery, while those with resectable tumour were scheduled to receive surgery alone. Neoadjuvant chemotherapy consisted of two cycles of platinum-based doublet chemotherapy. Concurrent radiotherapy of 50 Gy in 25 fractions over 5 weeks was performed via intensity-modulated radiation therapy. IORT was administered to the tumour bed with close margin. The primary endpoint was acute toxicity and secondary endpoints were late spinal cord and brachial plexus toxicity. Results Between August 22, 2014 and November 30, 2017, we enrolled nine patients (seven males and two females). Anaemia was the most common acute complication, with grade 3 anaemia occurring in three patients who received preoperative CCRT. Other side effects included pneumonia (1 patient), prolonged air leakage (1), and grade 1 brachial plexus injury (1). The average follow-up period was 29.4 (range; 13.3-50.4) months. All patients are alive. Distant metastasis was observed in two patients, one with contralateral lung metastasis and another with pericardial metastasis. Conclusions IORT with low-energy X-rays is a technically feasible and relatively safe treatment modality for patients with superior pulmonary sulcus tumours.

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Section: Discussionmentioning

confidence: 99%

Feasibility of intraoperative radiotherapy with X-rays for the treatment of superior sulcus tumours

Pan

Yang

Chen

et al. 2020

Preprint

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“…The irradiation campaign has been conducted on breast adenocarcinoma cells belonging to the MCF‐7 cell line; this cell line was isolated in 1970 and since then has been the object of many studies and improvements in the radiobiology field …”

Section: Methodsmentioning

confidence: 99%

“…[19,20] MCF-7 cells were purchased from ATCC (Cat# HTB-22) and cultured in Eagle's minimum essential medium (Euroclone SpA, Milan, Italy) supplemented with 10% fetal bovine serum (SigmaAldrich, St. Louis, MO, USA), 100 unit/ml penicillin/streptomycin (Euroclone SpA, Milan, Italy), 2 mM L-glutamine (Euroclone SpA; Milan, Italy), and 0.01% sodium pyruvate (Sigma-Aldrich, St. Louis, MO, USA) at 37°C in an atmosphere of 5% CO 2 and 90% humidity.…”

Section: Preparation Of Samplesmentioning

confidence: 99%

Analysis and characterization of the X‐ray beam produced by a PF device for radiotherapy applications

et al. 2015

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A plasma focus device, devoted to the study of a possible application to the radiotherapy treatment of malignant cells, has been recently put into operation. The low-energy (up to 200 keV) X-rays are produced by conversion of the electron beam generated by the device during the pinch phase. The X-ray spectrum has already been fully characterized, and an initial campaign of irradiation of specific cell cultures has been completed. At present, the links between the operational parameters of the actual device, the beam intensity, and the cell irradiation effects are being analyzed, trying to evaluate the advantage of the very high dose rate that can be delivered, of the order of several Gy in a few tens of nanoseconds. Preliminary results on radiobiological effectiveness are presented and discussed.

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“…However, there are reports postulating why this lower dose may be efficacious. One study published that the relative biological effectiveness of the 50-kV photons in a single dose may approach 1.5 but gives a similar relative biological effectiveness for 380 keV, so this would not explain a differential effect between these two methods [14]. Another study examined surgical wound fluid and noted that it stimulates tumor cell growth in vitro, and that with immediate irradiation, as in TARGIT, 3D growth, migration and invasion are relatively inhibited, but not eliminated [15].…”

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confidence: 93%

Strut-Adjusted Volume Implant: A Targeted Radiation Treatment in Breast Cancer

Yashar¹,

Mahmood²

2010

Future Oncol.

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Relative biological effectiveness of photon energies used in brachytherapy and intraoperative radiotherapy techniques for two breast cancer cell lines

Cited by 22 publications

References 24 publications

Feasibility of intraoperative radiotherapy with X-rays for the treatment of superior sulcus tumours

Feasibility of intraoperative radiotherapy with X-rays for the treatment of superior sulcus tumours

Analysis and characterization of the X‐ray beam produced by a PF device for radiotherapy applications

Strut-Adjusted Volume Implant: A Targeted Radiation Treatment in Breast Cancer

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