Relative CBV ratio on perfusion-weighted MRI indicates the probability of early recanalization after IV t-PA administration for acute ischemic stroke

Sohn, Sang-Wook; Park, Hyun-Seok; Cha, Jae‐Kwan; Kim, Dae-Hyun; Kang, Myongjin; Choi, Jeong Hee; Nah, Hyun‐Wook; Huh, Jae-Taeck

doi:10.1136/neurintsurg-2014-011501

Cited by 9 publications

(7 citation statements)

References 30 publications

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“…Possible explanations for this diversity in clinical outcomes have been proposed and include interindividual differences in collateral circulation, preconditioning, and microcirculation responses after ischemic impairment ( Thompson et al, 2013 ; Malik et al, 2014 ; Winship, 2015 ; Rost and Brodtmann, 2022 ). The cerebral collateral circulation is an evolutionarily conserved blood vessel network that maintains consistent cerebral perfusion when encountering physiological or pathophysiological changes in hemodynamics ( Sohn et al, 2016 ). The clinical progression of patients with chronic stroke can be evaluated using the status of collateral circulation in terms of the risk of stroke recurrence.…”

Section: Discussionmentioning

confidence: 99%

RETRACTED: Comparing the predictive value of quantitative magnetic resonance imaging parametric response mapping and conventional perfusion magnetic resonance imaging for clinical outcomes in patients with chronic ischemic stroke

He,

Zhou,

et al. 2023

Front. Neurosci.

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Predicting clinical outcomes after stroke, using magnetic resonance imaging (MRI) measures, remains a challenge. The purpose of this study was to investigate the prediction of long-term clinical outcomes after ischemic stroke using parametric response mapping (PRM) based on perfusion MRI data. Multiparametric perfusion MRI datasets from 30 patients with chronic ischemic stroke were acquired at four-time points ranging from V2 (6 weeks) to V5 (7 months) after stroke onset. All perfusion MR parameters were analyzed using the classic whole-lesion approach and voxel-based PRM at each time point. The imaging biomarkers from each acquired MRI metric that was predictive of both neurological and functional outcomes were prospectively investigated. For predicting clinical outcomes at V5, it was identified that PRMTmax-, PRMrCBV-, and PRMrCBV+ at V3 were superior to the mean values of the corresponding maps at V3. We identified correlations between the clinical prognosis after stroke and MRI parameters, emphasizing the superiority of the PRM over the whole-lesion approach for predicting long-term clinical outcomes. This indicates that complementary information for the predictive assessment of clinical outcomes can be obtained using PRM analysis. Moreover, new insights into the heterogeneity of stroke lesions revealed by PRM can help optimize the accurate stratification of patients with stroke and guide rehabilitation.

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Section: Discussionmentioning

confidence: 99%

RETRACTED: Comparing the predictive value of quantitative magnetic resonance imaging parametric response mapping and conventional perfusion magnetic resonance imaging for clinical outcomes in patients with chronic ischemic stroke

He,

Zhou,

et al. 2023

Front. Neurosci.

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“…At present, studies have suggested that CBV observed on PWI can determine the status of collateral circulation in patients with acute cerebral infarction, and can be used as a predictor of vascular recanalization after thrombolysis. [24] Therefore, acute cerebral infarction can determine the establishment of collateral circulation and openness by CBV measurement. [3,25] When acute cerebral infarction occurs along with low perfusion in brain tissue, the deoxygenated-to-oxygenated hemoglobin ratio varies according to the oxygen extraction fraction.…”

Section: Discussionmentioning

confidence: 99%

Clinical application of susceptibility-weighted imaging in the evaluation of leptomeningeal collateralization

Yang¹,

Luo

2018

Medicine

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The feasibility of using susceptibility-weighted imaging (SWI) in a clinical setting was assessed for quantifying leptomeningeal collateralization.Eighteen patients with stroke and acute infarction underwent diffusion-weighted imaging, SWI, perfusion-weighted imaging, and magnetic resonance angiography within 3 days after symptom onset. Lesions were evaluated by the Alberta Stroke Program Early CT score (ASPECTS), based on mean transit time, SWI, and cerebral blood volume (CBV).For evaluating ischemic penumbra and leptomeningeal collateralization, the SWI-ASPECTS significantly correlated, respectively, with mean transit time and CBV-ASPECTS (Spearman test, r = 0.793 and 0.682; P < .001, both).The SWI may be useful to quantify leptomeningeal collateralization in patients with acute cerebral infarction.

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“…CBV color maps have been reported to show a close correlation with CBV images derived from CT perfusion. 12,13) We reported the effectiveness of C-arm CBV measurement by transarterial contrast administration in the ascending aorta immediately above the aortic valve, which facilitated the collection of CBV data during angiography. 5,14) In this study, we performed a C-arm CBV study in patients with acute ischemic stroke and calculated the relative CBV ratio, which is the ratio of CBV on the ischemic ipsilateral side to CBV on the normal contralateral side.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Patients with Acute Ischemic Stroke Using Angiographic C-arm Cerebral Blood Volume (C-arm CBV) Measurements

Moriya¹,

Itokawa²,

Fujimoto³

et al. 2018

JNET

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Objective: CT-like images and cerebral blood volume (CBV) measurements have become available due to technical improvements in the angiographic C-arm system and workstation. In this study, we evaluated the usefulness of C-arm CBV measurements in patients with acute ischemic stroke. Methods:The study included 27 consecutive patients admitted for acute ischemic stroke due to major intracranial artery occlusion within 7 hours of onset. Cerebral angiography and C-arm CBV measurements were performed immediately after CT or MRI. The areas with reduced CBV in CBV color maps were classified into infarcted and non-infarcted areas according to CT/MRI images obtained 8-48 hours after onset, and their relationship with CBV was retrospectively evaluated. Results:The mean CBV values and the relative CBV ratios (ipsilateral/contralateral side) were 1.29 ± 0.51 mL/100 g and 0.41 ± 0.17 in the infarcted area and 3.19 ± 0.17 mL/100 g and 0.8 ± 0.1 in the non-infarcted areas. The CBV values and relative CBV ratios in infarcted areas with hemorrhage (n = 5) were 0.95 ± 0.56 mL/100 g and 0.3 ± 0.17, and significantly lower than in infarcted areas without hemorrhage.Conclusion: C-arm CBV measurements with an angiography system can be performed readily in a short time and may provide useful information for the treatment of acute ischemic stroke patients.

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Relative CBV ratio on perfusion-weighted MRI indicates the probability of early recanalization after IV t-PA administration for acute ischemic stroke

Abstract: The results of this study suggest that the rCBV ratio on PWI might serve as a useful indicator of ER after IV t-PA administration.

Cited by 9 publications

References 30 publications

RETRACTED: Comparing the predictive value of quantitative magnetic resonance imaging parametric response mapping and conventional perfusion magnetic resonance imaging for clinical outcomes in patients with chronic ischemic stroke

RETRACTED: Comparing the predictive value of quantitative magnetic resonance imaging parametric response mapping and conventional perfusion magnetic resonance imaging for clinical outcomes in patients with chronic ischemic stroke

Clinical application of susceptibility-weighted imaging in the evaluation of leptomeningeal collateralization

Evaluation of Patients with Acute Ischemic Stroke Using Angiographic C-arm Cerebral Blood Volume (C-arm CBV) Measurements

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