Relative contribution of cognitive and physical disability components to quality of life in MS

Schependom, Jeroen Van; D'hooghe, Marie B; Schepper, Mélanie De; Cleynhens, Krista; D'hooge, Mieke; Haelewyck, Marie-Claire; Keyser, Jacques De; Nagels, Guy

doi:10.1016/j.jns.2013.10.020

Cited by 8 publications

(6 citation statements)

References 43 publications

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“…In many respects, the SDMT may provide a proxy for overall cognitive functioning [44] but a more detailed cognitive assessment of the domains directly trained may have provided additional insight into effectiveness of cognitive training. BICAMS is primarily designed as a screening tool for cognitive impairment in MS assessing a limited number of domains.…”

Section: Discussionmentioning

confidence: 99%

A Randomised Controlled Trial of Efficacy of Cognitive Rehabilitation in Multiple Sclerosis: A Cognitive, Behavioural, and MRI Study

et al. 2016

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Aim. To explore the efficacy of home-based, computerised, cognitive rehabilitation in patients with multiple sclerosis using neuropsychological assessment and advanced structural and functional magnetic resonance imaging (fMRI). Methods. 38 patients with MS and cognitive impairment on the Brief International Cognitive Assessment for MS (BICAMS) were enrolled. Patients were randomised to undergo 45 minutes of computerised cognitive rehabilitation using RehaCom software (n = 19) three times weekly for six weeks or to a control condition (n = 19). Neuropsychological and MRI data were obtained at baseline (time 1), following the 6-week intervention (time 2), and after a further twelve weeks (time 3). Cortical activations were explored using fMRI and microstructural changes were explored using quantitative magnetisation transfer (QMT) imaging. Results. The treatment group showed a greater improvement in SDMT gain scores between baseline and time 2 compared to the control group (p = 0.005). The treatment group exhibited increased activation in the bilateral prefrontal cortex and right temporoparietal regions relative to control group at time 3 (p < 0.05FWE corrected). No significant changes were observed on QMT. Conclusion. This study supports the hypothesis that home-based, computerised, cognitive rehabilitation may be effective in improving cognitive performance in patients with MS. Clinical trials registration is ISRCTN54901925.

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Section: Discussionmentioning

confidence: 99%

A Randomised Controlled Trial of Efficacy of Cognitive Rehabilitation in Multiple Sclerosis: A Cognitive, Behavioural, and MRI Study

et al. 2016

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“…A recent study revealed that vitamin D levels were associated with cognitive function, which is an important factor affecting QOL in older people with chronic conditions [ 41 ]. Furthermore, previous studies have reported significant declines of self-care [ 42 ] and usual activities in patients with cognitive impairment [ 43 , 44 ]. Although we could not evaluate cognitive function in our study population, our results showed significant impairment of self-care and usual activities in the vitamin D deficiency group compared with the control group.…”

Section: Discussionmentioning

confidence: 99%

Association between serum vitamin D status and health-related quality of life (HRQOL) in an older Korean population with radiographic knee osteoarthritis: data from the Korean national health and nutrition examination survey (2010–2011)

Kim

Jeeyon

Kim

et al. 2015

Health Qual Life Outcomes

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BackgroundVitamin D is important in bone health and its relationship with osteoarthritis has recently been reported. Both vitamin D deficiency and knee osteoarthritis are age dependent and are known to affect quality of life (QOL) in older populations. In this study, we aimed to determine the association between vitamin D status and health-related quality of life (HRQOL) in an older Korean population with knee osteoarthritis.MethodsA total of 2,165 participants aged ≥50 years with radiographic knee osteoarthritis defined as Kellgren-Lawrence (KL) grade ≥2 were selected from data from the 5th Korean National Health and Nutrition Examination Survey (KNHANES V), a representative cross-sectional nationwide survey conducted in 2010–2011. They stratified into two levels by vitamin D status (deficiency <10 ng/dL and normal ≥10 ng/dL). HRQOL was measured using the EuroQOL visual analogue scale (EQ-VAS) and the five dimensions and summary index of the EuroQOL-5 dimension (EQ-5D).ResultsThe vitamin D deficiency group was more likely to report problems with mobility, self-care, and usual activities. Vitamin D deficiency was significantly associated with poor HRQOL indicated by the lowest quartile of EQ-VAS (unadjusted odds ratio [OR] =1.832, p = 0.006) and the lowest quartile of the EQ-5D index (unadjusted OR = 1.992, p = 0.003). Theses associations of vitamin D status with EQ-VAS and EQ-5D index were maintained after adjustment for age and sex (Model 1: OR = 1.677, p = 0.022 and OR = 1.701, p = 0.021, respectively). The significant associations of vitamin D status with EQ-VAS were maintained after adjustment for other possible covariates (Model 3: OR = 1.562, p = 0.044). Also, a trend of associations between vitamin D status and EQ-5D index were shown after adjustment for other covariates (Model3: OR = 1.681, p = 0.056).ConclusionThis is the first study to reveal that vitamin D status is independently associated with HRQOL in an older Korean population with knee osteoarthritis. Our results suggest that the maintenance of sufficient vitamin D status may be important to prevent QOL decline in older populations with knee osteoarthritis.Electronic supplementary materialThe online version of this article (doi:10.1186/s12955-015-0245-1) contains supplementary material, which is available to authorized users.

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“…Several authors have identified, over the years, various factors that negatively influence HRQoL in these patients such as low household income, a high EDSS score, a low score in the 9HPT test, a diminished verbal responsiveness, and a debilitating and progressive disease course. All of these factors have been linked to lower HRQoL, and it has been shown that lower HRQoL portends worse survival in PwMS [ 61 , 62 , 63 ].…”

Section: Qol In Msmentioning

confidence: 99%

“…Studies show that people with MS experience a reduction in QoL due to psychosocial challenges such as sexual dysfunction, problems with defecation, feelings of impotence and shame, and social stigma [ 55 ]. In addition, physical disability and loss of upper limb function can significantly limit daily activities and have been shown to correlate with lower QoL measurements [ 63 ].…”

Section: Qol In Msmentioning

confidence: 99%

Impact of Cognitive Impairment on Quality of Life in Multiple Sclerosis Patients—A Comprehensive Review

Gómez-Melero,

Caballero-Villarraso,

Escribano

et al. 2024

JCM

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Multiple sclerosis (MS) is characterized by a variety of symptoms that have a major impact on quality of life (QoL) even in early stages. In addition to individual motor, sensory, visual disturbances, and brainstem and sphincter disorders, which are expressed through the widely used Expanded Disability Status Scale (EDSS), other manifestations of MS have a detrimental effect on overall functioning and quality of life, such as cognitive impairment, depression, anxiety, fatigue, and pain. However, when talking about QoL, categorical definitions cannot be used because although the concept is generally understood, it is highly nuanced. Suffering from MS can significantly reduce QoL. Numerous research studies have focused on trying to identify and assess which are the elements that most affect the loss of QoL in MS people. However, in addition to the fact that the measurement of QoL can be subjective, it is very difficult to consider these elements in isolation, as they are interrelated. One such limiting factor of QoL that has been investigated is cognitive impairment (CI). This has been shown to have an impact on the lives of MS people, although the different approaches that have been taken to assess CI have evident limitations.

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Relative contribution of cognitive and physical disability components to quality of life in MS

Cited by 8 publications

References 43 publications

A Randomised Controlled Trial of Efficacy of Cognitive Rehabilitation in Multiple Sclerosis: A Cognitive, Behavioural, and MRI Study

A Randomised Controlled Trial of Efficacy of Cognitive Rehabilitation in Multiple Sclerosis: A Cognitive, Behavioural, and MRI Study

Association between serum vitamin D status and health-related quality of life (HRQOL) in an older Korean population with radiographic knee osteoarthritis: data from the Korean national health and nutrition examination survey (2010–2011)

Impact of Cognitive Impairment on Quality of Life in Multiple Sclerosis Patients—A Comprehensive Review

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