Relative cost-effectiveness of a norovirus vaccine in the deployed military setting compared to a vaccine against Campylobacter sp., ETEC, and Shigella sp.

Tallant, Aaron; Porter, Chad K.; Putnam, Shannon D.; Tribble, David R.; Hooper, Tomoko I.; Riddle, Mark S.

doi:10.1016/j.vaccine.2014.07.070

Cited by 15 publications

(13 citation statements)

References 29 publications

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“…Given TD's mission aborting potential for military troops,43 in whom incapacitation could pose a further threat to life,33,42 recommendations to military members operating in this geographic area should take NV-associated risks into account.…”

Section: Discussionmentioning

confidence: 99%

Case–Case Analysis Using 7 Years of Travelers' Diarrhea Surveillance Data: Preventive and Travel Medicine Applications in Cusco, Peru

Jennings¹,

Tilley²,

Ballard³

et al. 2017

The American Society of Tropical Medicine and Hygiene

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In Cusco, Peru, and South America in general, there is a dearth of travelers' diarrhea (TD) data concerning the clinical features associated with enteropathogen-specific infections and destination-specific risk behaviors. Understanding these factors would allow travel medicine providers to tailor interventions to patients' risk profiles and travel destination. To characterize TD etiology, evaluate region-specific TD risk factors, and examine relationships between preventive recommendations and risk-taking behaviors among medium- to long-term travelers' from high-income countries, we conducted this case–case analysis using 7 years of prospective surveillance data from adult travelers' presenting with TD to a physician in Cusco. At the time of enrollment, participants provided a stool sample and answered survey questions about demographics, risk behaviors, and the clinical features of illness. Stool samples were tested for norovirus (NV), bacteria, and parasites using conventional methods. Data obtained were then analyzed using case–case methods. NV (14%), enterotoxigenic Escherichia coli (11%), and Campylobacter (9%), notably ciprofloxacin-resistant Campylobacter, were the most frequently identified pathogens among adults with TD. Coinfection with multiple enteropathogens occurred in 5% of cases. NV caused severe disease relative to other TD-associated pathogens identified, confining over 90% of infected individuals to bed. Destination-specific risk factors include consumption of the local beverage “chicha,” which was associated with Cryptosporidium infection. Preventive interventions, such as vaccines, directed against these pathogens could significantly reduce the burden of TD.

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Section: Discussionmentioning

confidence: 99%

Case–Case Analysis Using 7 Years of Travelers' Diarrhea Surveillance Data: Preventive and Travel Medicine Applications in Cusco, Peru

Jennings¹,

Tilley²,

Ballard³

et al. 2017

The American Society of Tropical Medicine and Hygiene

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“…The remaining 4 studies (4%) all used ad hoc approaches that (41, 45-48, 51, 56-58, 60, 62, 64, 66, 68, 70, 72-75, 79, 81, 83, 84, 87-90, 92, 93, 95, 97, 98, 100-102, 105, 107-110, 113, 117-125) North-America 34 (39, 40, 43, 44, 50, 52-55, 59, 61, 63, 65, 69, 71, 76, 80, 82, 85, 86, 91, 94, 96, 99, 103, 106, 111, 112, 114-116, 126- (39, 41, 42, 44, 45,49,50,(52)(53)(54)(55)59,60,67,68,70,71,76,77,82,87,95,115, 128) Inferred: 19 (40, 43, 46,57,61,63,65,80,86,91,92,94,96,103,111,116,(125)(126)(127)56,62,64,66,69,72,73,75,78,79,81,(83)(84)(85)…”

Section: Productivity Estimation Methodsmentioning

confidence: 99%

Productivity estimation in economic evaluations of occupational health and safety interventions: a systematic review

Steel¹,

Godderis²,

Luyten³

2018

Scand J Work Environ Health

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Productivity estimation is a key factor in demonstrating the cost-effectiveness of occupational health and safety (OHS). However, the studies analysed in this systematic review lack standardization, exclude important factors, and the precision, validity and reliability of estimates widely differs. Researchers should be aware of how the method and precision of estimating productivity affects results, and, ultimately, the economic attractiveness of OHS. Key terms: absenteeism; cost-effectiveness; economic evaluation; friction cost; human capital; indirect cost; measurement; methodology; occupational health; occupational health and safety; presenteeism; productivity estimation; review; systematic review; valuation; work This article in PubMed: www.ncbi.nlm.nih.gov/pubmed/29405241 Additional materialPlease note that there is additional material available belonging to this article on the Scandinavian Journal of Work, Environment & Health -website. Scand J Work Environ Health -online first 1Review Productivity estimation in economic evaluations of occupational health and safety interventions: a systematic review by Jonas Steel, MSc, 1 Lode Godderis, MD,2,3 Jeroen Luyten, PhD 1,4 Steel J, Godderis L, Luyten J. Productivity estimation in economic evaluations of occupational health and safety interventions: a systematic review. Scand J Work Environ Health -online first. doi:10.5271/sjweh.3715Objectives Occupational health and safety (OHS) interventions' effect on worker productivity is an essential, but complex element of the value of these programs. The trustworthiness of economic evaluation studies, aiming to provide guidance to decision-makers in the field of OHS, depends at least partly on how accurately productivity changes are measured. We aim to review the methods used to estimate productivity changes in recently published economic evaluations of OHS interventions. MethodsWe performed systematic searches of economic evaluations of OHS programs published between 2007 and 2017 and reviewed these studies' methods to quantify the programs' impact on worker productivity ResultsOf the 90 identified studies, 44 used a human capital approach, 17 a friction cost approach, 13 stated productivity in natural units (eg, a cost-per-absence-day-avoided), 7 made use of compensation expenses, 4 used output-based methods, 4 an "ad hoc" approach, and 1 study did not state its method. Different approaches were combined in 19 studies. Within these methods, we observed a wide diversity in their precise implementation, especially regarding the measurement and valuation of absenteeism and presenteeism.Conclusions Productivity is a key element of the economic attractiveness of investing in OHS. Economic evaluation studies of OHS would benefit from more methodological standardization in their approach to quantifying productivity change. Future research should better account for the methodological uncertainty that occurs in estimating it in order to demonstrate the impact that particular choices and approaches to productivity estimation ca...

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“…Tallant et al ’s [111■■] recently published a new model of diarrhea vaccine cost-effectiveness for deploying US military personnel. Using a diarrhea-based definition of norovirus disease, they calculated a norovirus vaccine cost-effectiveness of $1,344 per duty day lost averted.…”

Section: Norovirus Vaccines In the Tropicsmentioning

confidence: 99%

“…Using a diarrhea-based definition of norovirus disease, they calculated a norovirus vaccine cost-effectiveness of $1,344 per duty day lost averted. This model assumed a two-dose vaccination cost of $60.14 per individual vaccinated; 75% vaccine coverage; 80% vaccine effectiveness, reflecting the minimally acceptable military vaccine profile, rather than the efficacy of vaccines currently under development [112,113]; and a duration of immunity of 3.5 months, which is twice the average duration of US military deployments [111■■]. The estimated cost per duty day lost averted for military vaccines against Campylobacter sp., ETEC, and Shigella sp.…”

Section: Norovirus Vaccines In the Tropicsmentioning

confidence: 99%

“…The estimated cost per duty day lost averted for military vaccines against Campylobacter sp., ETEC, and Shigella sp. were $800, $776, and $1,275, respectively [111■■]. When the norovirus disease definition was modified to include vomiting, the norovirus vaccine cost per duty day lost averted decreased to $572, making it the most cost-effective of the four hypothetical diarrhea vaccines evaluated (against Campylobacter sp., ETEC, Shigella sp., and norovirus) [111■■].…”

Section: Norovirus Vaccines In the Tropicsmentioning

confidence: 99%

See 1 more Smart Citation

Tropical and travel-associated norovirus

Ballard¹,

Saito

Mirelman

et al. 2015

Current Opinion in Infectious Diseases

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Purpose of review We highlight recent advances relevant to understanding norovirus infections in the tropics, both in populations living in developing settings and travelers to these regions. Recent findings Because of the decrease in diarrheal disease associated with the global rollout of vaccines against rotavirus, norovirus is emerging as the predominant cause of diarrhea morbidity among children in the tropics, and evidence suggests that it contributes to adult disease in endemic populations and travelers. In addition to identifying potential target populations for preventive measures, we provide an update on norovirus vaccine development and concepts related to their implementation in low-income and middle-income countries. Summary These current concepts related to norovirus-attributable disease burden, clinical significance, and economic impact can potentially be applied to tailoring efforts to prevent and mitigate the effects of this important enteropathogen.

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Relative cost-effectiveness of a norovirus vaccine in the deployed military setting compared to a vaccine against Campylobacter sp., ETEC, and Shigella sp.

Cited by 15 publications

References 29 publications

Case–Case Analysis Using 7 Years of Travelers' Diarrhea Surveillance Data: Preventive and Travel Medicine Applications in Cusco, Peru

Case–Case Analysis Using 7 Years of Travelers' Diarrhea Surveillance Data: Preventive and Travel Medicine Applications in Cusco, Peru

Productivity estimation in economic evaluations of occupational health and safety interventions: a systematic review

Tropical and travel-associated norovirus

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