Relative decrease in hemoglobin and outcomes in patients undergoing kidney transplantation surgery: A retrospective cohort study

Macisaac, S.; Ramanakumar, Agnihotram V.; Saw, Chee Loong; Naessens, Véronique; Saberi, Nasim; Cantarovich, Marcelo; Baran, Dana; Paraskevas, Steven; Chaudhury, Prosanto; Sandal, Shaifali

doi:10.1016/j.amjsurg.2021.03.002

Cited by 1 publication

(3 citation statements)

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“…In this study, there was a tendency toward higher DGF rates in the transfusion group. Although this finding was not statistically significant, it was in line with that of MacIsaac et al [ 9 ], in which the rate of DGF in transplant patients was up to 26%[ 9 ]. Similarly, in a retrospective cohort study on 1258 kidney transplant recipients who were followed for a median of 1405 d, DGF was as high as 41% in a transfusion group vs 15% in a non-transfusion group ( P < 0.0001)[ 6 ].…”

Section: Discussionsupporting

confidence: 87%

“…Anemia carries significant risk in kidney transplant recipients. A drop of Hb level > 30% of its pre-transplant level was reported to be associated with higher all-cause graft failure and longer length of hospital stay, with a greater risk in those who required blood transfusion of > 3 units and those with longer cold ischemia time[ 9 ]. However, the effect of peri-transplantation blood transfusion on graft outcome have not been well established.…”

Section: Discussionmentioning

confidence: 99%

“…In a previous prospective observational study, worse transplantation outcomes were linked to the number of transfusion episodes (pre and post-transplantation), regardless of the total number of transfusion units[ 20 ]. In another study, poor transplantation outcomes were linked to the number of transfusion units (> 3 units)[ 9 ]. In our study, creatinine levels tended to increase toward the end of the follow-up period in the transfusion group, but this finding was not statistically significant.…”

Section: Discussionmentioning

confidence: 99%

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Is peri-transplant blood transfusion associated with worse transplant outcomes? A retrospective study

Bukhari¹,

Alhomayani²,

Eid³

et al. 2023

World J Transplant

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BACKGROUND Blood transfusion is common during the peri-transplantation period. The incidence of immunological reactions to blood transfusion after kidney tran splantation and their consequences on graft outcomes have not been extensively studied. AIM To examine the risk of graft rejection and loss in patients who received blood transfusion in the immediate peri-transplantation period. METHODS We conducted a single-center retrospective cohort study of 105 kidney recipients, among them 54 patients received leukodepleted blood transfusion at our center between January 2017 and March 2020. RESULTS This study included 105 kidney recipients, of which 80% kidneys were from living-related donors, 14% from living-unrelated donors, and 6% from deceased donors. Living-related donors were mostly first-degree relatives (74.5%), while the rest were second-degree relatives. The patients were divided into transfusion ( n = 54) and non-transfusion ( n = 51) groups. The average hemoglobin level at which blood transfusion was commenced was 7.4 ± 0.9 mg/dL. There were no differences between the groups in terms of rejection rates, graft loss, or death. During the study period, there was no significant difference in creatinine level progression between the two groups. Delayed graft function was higher in the transfusion group; however, this finding was not statistically significant. A high number of transfused packed red blood cells was significantly associated with increased creatinine levels at the end of the study. CONCLUSION Leukodepleted blood transfusion was not associated with a higher risk of rejection, graft loss, or death in kidney transplant recipients.

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Section: Discussionsupporting

confidence: 87%

Section: Discussionmentioning

confidence: 99%