Relative Effectiveness of Parenteral, Intratracheal, and Aerosol Penicillin in Chronic Suppurative Disease of the Lung

Bronchiectasis

“…Administration of penicillin exclusively by aerosol or intratracheally is not very effective; this is due to the rather low blood titres that can be obtained (GAENSLER et al 1949); RooTH) and the presence of the micro-organisms deep in the bronchial tissues. The consideration that deficient blood flow in the diseased tissues might be an argument in favour of the local application of drugs, has been abandoned now it has appeared that, although the perfusion of the pulmonary arteries in the diseased area has often decreased considerably, the supply of blood from the bronchial arteries may be increased to an important degree (LIEBOW; RoozENBURG ).…”