Relative effects of heavy alcohol use and Hepatitis C in decompensated chronic liver disease in a hospital inpatient population

Mankal, Pavan; Abed, Jean; Aristy, Jose David; Munot, Khushboo; Suneja, Upma; Engelson, Ellen S.; Kotler, Donald P.

doi:10.3109/00952990.2014.964358

Cited by 7 publications

(3 citation statements)

References 37 publications

(40 reference statements)

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“…In addition to fibrosis and cirrhosis the risk of decompensation is also increased after alcohol. Data suggested that heavy, but not moderate, alcohol intake was associated with a higher risk for hepatic decompensation in patients with cirrhosis than HCV infection was[ 215 ], a finding confirmed in a population study of HCV-infected individuals. Age-adjusted decompensated cirrhosis incidence was considerably higher in people with AUDs in British Columbia, New South Wales and Scotland; AUD was present in 28%, 32% and 50% of those with decompensated cirrhosis, respectively[ 216 ].…”

Section: Effect Of Alcohol Consumption In Hcv-related Fibrosis and Ci...mentioning

confidence: 87%

Hepatitis C virus: A critical approach to who really needs treatment

Voumvouraki¹

2022

WJH

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Introduction of effective drugs in the treatment of hepatitis C virus (HCV) infection has prompted the World Health Organization to declare a global eradication target by 2030. Propositions have been made to screen the general population and treat all HCV carriers irrespective of the disease status. A year ago the new severe acute respiratory syndrome coronavirus 2 virus appeared causing a worldwide pandemic of coronavirus disease 2019 disease. Huge financial resources were redirected, and the pandemic became the first priority in every country. In this review, we examined the feasibility of the World Health Organization elimination program and the actual natural course of HCV infection. We also identified and analyzed certain comorbidity factors that may aggravate the progress of HCV and some marginalized subpopulations with characteristics favoring HCV dissemination. Alcohol consumption, HIV coinfection and the presence of components of metabolic syndrome including obesity, hyperuricemia and overt diabetes were comorbidities mostly responsible for increased liver-related morbidity and mortality of HCV. We also examined the significance of special subpopulations like people who inject drugs and males having sex with males. Finally, we proposed a different micro-elimination screening and treatment program that can be implemented in all countries irrespective of income. We suggest that screening and treatment of HCV carriers should be limited only in these particular groups.

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Section: Effect Of Alcohol Consumption In Hcv-related Fibrosis and Ci...mentioning

confidence: 87%

Hepatitis C virus: A critical approach to who really needs treatment

Voumvouraki¹

2022

WJH

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“…concluded that patients with this viral infection had lower BMD than ex-alcohol users 37 ; furthermore, Mankal et al . found that alcoholic liver disease is associated with an increased risk of hepatic decompensation 38 .…”

Section: Discussionmentioning

confidence: 99%

Safety and efficacy of risedronate for patients with esophageal varices and liver cirrhosis: a non-randomized clinical trial

Lima

Santos

Nunes

et al. 2019

Sci Rep

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Despite the high prevalence of osteoporosis in liver cirrhosis, the indication of bisphosphonates for patients with esophageal varices has been avoided due to risk of digestive mucosal damage. Therefore, this study aimed to evaluate the safety profile of risedronate treatment for patients with osteoporosis, liver cirrhosis and esophageal varices with low risk of bleeding. A total of 120 patients were allocated into two groups according to their bone mineral density measured by dual-energy X-ray absorptiometry. In the intervention group, 57 subjects with osteoporosis received oral risedronate at 35 mg weekly plus daily calcium and vitamin D supplementation. In the control group, 63 subjects with osteopenia received only calcium and vitamin D. The groups received the treatment for one year and underwent surveillance endoscopies at six and 12 months, as well as a control dual-energy X-ray absorptiometry after a 12-month follow-up. The study received Institutional Review Board approval. The groups had not only comparable Model for End-stage Liver Disease score and esophageal varices degree, but also similar incidence of digestive adverse effects. A significant improvement was achieved in the intervention group in the lumbar spine T score (p < 0.001). The results suggest that risedronate may be safely used in liver cirrhosis and esophageal varices with low bleeding risk under endoscopic surveillance, thus allowing bone mass recovery.

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“…12 Alcohol-related diagnoses (ARD), including alcohol use disorder and other conditions caused by alcohol (e.g., alcoholic liver disease, alcoholic gastritis), are commonly associated with conditions that lead to MICU admission among HCV+ patients. 13 ARD are also common among HIV+ patients 14 , and sequalae such as 6 physiologic injury and mortality 16 occur at lower levels of alcohol exposure than among uninfected patients. Importantly, even low levels of alcohol use can aggravate deleterious effects of HIV and HCV infection on the liver.…”

Section: Introductionmentioning

confidence: 99%

Medical Intensive Care Unit Admission Among Patients With and Without HIV, Hepatitis C Virus, and Alcohol-Related Diagnoses in the United States: A National, Retrospective Cohort Study, 1997–2014

Rentsch

Tate

Steel

et al. 2019

JAIDS Journal of Acquired Immune Deficiency Syndromes

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Background: HIV, hepatitis C virus (HCV), and alcohol-related diagnoses (ARD) independently contribute increased risk for all-cause hospitalization. We sought to determine annual medical intensive care unit (MICU) admission rates and relative risk of MICU admission between 1997 and 2014 among people with and without HIV, HCV, and ARD, using data from the largest HIV and HCV care provider in the United States. Setting: Veterans Health Administration. Methods: Annual MICU admission rates were calculated among 155,550 patients in the Veterans Aging Cohort Study by HIV, HCV, and ARD status. Adjusted rate ratios (RR) and 95% confidence intervals (CI) were estimated with Poisson regression. Significance of trends in ageadjusted admission rates were tested with generalized linear regression. Models were stratified by calendar period to identify shifts in MICU admission risk over time.

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Relative effects of heavy alcohol use and Hepatitis C in decompensated chronic liver disease in a hospital inpatient population

Abstract: While both heavy alcohol use and HCV infection are associated with risk of developing CLD, our data suggest that heavy, but not moderate, alcohol consumption is associated with a greater risk for hepatic decompensation in patients with cirrhosis than does HCV infection.

Cited by 7 publications

References 37 publications

Hepatitis C virus: A critical approach to who really needs treatment

Hepatitis C virus: A critical approach to who really needs treatment

Safety and efficacy of risedronate for patients with esophageal varices and liver cirrhosis: a non-randomized clinical trial

Medical Intensive Care Unit Admission Among Patients With and Without HIV, Hepatitis C Virus, and Alcohol-Related Diagnoses in the United States: A National, Retrospective Cohort Study, 1997–2014

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