Relative Effects of Repetitive Transcranial Magnetic Stimulation and Electroconvulsive Therapy on Mood and Memory: A Neurocognitive Risk–Benefit Analysis

O’Connor, Margaret; Brenninkmeyer, Cornelia; Morgan, Amy J.; Bloomingdale, Kerry; Thall, Mark; Vasile, Russell G.; Leone, Alvaro

doi:10.1097/00146965-200306000-00005

Cited by 60 publications

(42 citation statements)

References 32 publications

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“…In addition, we showed no correlation between mood improvement and cognitive improvement, suggesting that independent mechanisms were responsible for cognitive and mood changes. In accordance, it has been demonstrated that cortical stimulation with transcranial magnetic stimulation results in a cognitive improvement of some neuropsychological functions that is independent of the mood improvement [Hausmann et al, 2004;Moser et al, 2002;O'Connor et al, 2003]. An important consideration is that other electrode montages that may also result in an antidepressant effect, such as cathodal stimulation of the right DLPFC, were not tested in our study.…”

supporting

confidence: 57%

Cognitive effects of repeated sessions of transcranial direct current stimulation in patients with depression

et al. 2006

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supporting

confidence: 57%

Cognitive effects of repeated sessions of transcranial direct current stimulation in patients with depression

et al. 2006

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“…9 Differences relative to studies documenting impaired processing speed and verbal and working memory after ECT, 17,39,40 or more global cognitive impairment, 41 might be due to the shorter interval between the last ECT session and posttreatment assessment in those studies. There is an active ongoing debate about the neurocognitive side effects of ECT, but they have not been investigated by randomized studies, with the exception of continuation ECT.…”

Section: Discussionmentioning

confidence: 95%

The Effect of Electroconvulsive Therapy on Neurocognitive Function in Treatment-Resistant Bipolar Disorder Depression

Keßler¹,

Schoeyen²,

Andreassen³

et al. 2014

J. Clin. Psychiatry

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Objective:To compare the effects of right unilateral (RUL) electroconvulsive therapy (ECT) and algorithm-based pharmacologic treatment (APT) on neurocognitive function in treatment-resistant bipolar disorder depression. Method:Inpatients with DSM-IV-TR-diagnosed, treatment-resistant bipolar depression, who were acutely admitted to 1 of the 7 clinical study centers in Norway, were recruited from May 2008 to April 2011 into a prospective, randomized controlled, 6-week acute treatment trial. General neurocognitive function was assessed with the MATRICS Consensus Cognitive Battery (MCCB), and retrograde memory for autobiographical events was assessed with the Autobiographical Memory Interview-Short Form (AMI-SF) before and shortly after (mean = 23.5 days) a trial with either RUL brief-pulse ECT (mean dose = 233.3 mC) or APT.Results: Seventy-three patients entered, and 39 (n ECT = 19, n APT = 20) completed. Both groups showed improvements in all MCCB domain scores, with no significant differences between the study groups (no interaction effect: F 1,37 = 1.52, P = NS). Improvements in neurocognitive performance were significantly correlated with reductions in depression ratings posttreatment. The AMI-SF score was significantly lower (based on consistent answers from pre-to posttreatment) in the ECT group (72.9%) than in the APT group (80.8%, P = .025), indicating reduced consistency in autobiographical memory after ECT. Conclusions:General neurocognitive function was unaffected by RUL brief-pulse ECT treatment and positively related to improved mood in bipolar depression. Autobiographical memory consistency was reduced in patients treated with ECT. The results suggest that ECT can be used in treatment-resistant bipolar depression without compromising general neurocognitive function. The clinical relevance of reduced autobiographical memory consistency in the ECT group requires further investigation.Trial Registration: ClinicalTrials.gov identifier: NCT00664976

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“…Despite mixed results for healthy participants, a number of promising rTMS studies have shown beneficial WM effects in neuropsychiatric patients, both for depression (O'Connor et al 2003;Fabre et al 2004;Hausmann et al 2004;Schulze-Rauschenbach et al 2005;Boggio et al 2005;Kuroda et al 2006;Bloch et al 2008;Vanderhasselt et al 2009;Guse et al 2010) and schizophrenia (Demirtas-Tatlidede et al 2013;Levkovitz et al 2011;Barr et al 2013). Compromised cortical activity of neuropsychiatric patients, associated with hypo-dopaminergic states (Stahl 2013) and neurophysiological inhibitory deficits (Radhu et al 2013), may explain these findings.…”

Section: Discussionmentioning

confidence: 99%

Repetitive transcranial magnetic stimulation of the dorsolateral prefrontal cortex enhances working memory

et al. 2016

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Relative Effects of Repetitive Transcranial Magnetic Stimulation and Electroconvulsive Therapy on Mood and Memory: A Neurocognitive Risk–Benefit Analysis

Cited by 60 publications

References 32 publications

Cognitive effects of repeated sessions of transcranial direct current stimulation in patients with depression

Cognitive effects of repeated sessions of transcranial direct current stimulation in patients with depression

The Effect of Electroconvulsive Therapy on Neurocognitive Function in Treatment-Resistant Bipolar Disorder Depression

Repetitive transcranial magnetic stimulation of the dorsolateral prefrontal cortex enhances working memory

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