RELATIVE EFFICIENCY OF ABSORPTION OF IgG<sub>1</sub> IgG<sub>2</sub>, IgA AND IgM IN THE NEWBORN CALF

Mr, Brandon; Lascelles, A. K.

doi:10.1038/icb.1971.69

Cited by 32 publications

(8 citation statements)

References 2 publications

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“…The half-life of the two major IgG isotypes (IgG1, IgG2) have been reported in several studies but the values are extremely divergent between publications (for a review, see Butler (56)). However, the data indicate that they both fall in the range of 10 -22 days (60,61), with a longer half-life for IgG2 (62,63). Based on the positive correlation between binding affinity and halflife, these data may suggest that IgG2 binds more effectively to the FcRn than IgG1.…”

Section: Bovine Igg Metabolismmentioning

confidence: 77%

Cloning and Characterization of the Bovine MHC Class I-Like Fc Receptor

Kacskovıcs

Simister

et al. 2000

The Journal of Immunology

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In the cow, maternal immunity is exclusively mediated by colostral Igs, but the receptor responsible for the IgG transport has not yet been identified. The role of an IgG-Fc receptor (FcRn) that resembles a class I MHC Ag in transporting IgGs through epithelial cells was recently shown in selected species. We now report the cloning and characterization of the bovine FcRn (bFcRn). The cDNA and deduced amino acid sequences show high similarity to the FcRn in other species, and it consists of three extracellular domains, a hydrophobic transmembrane region, and a cytoplasmic tail. Despite the high similarity of the extracellular domains with other species, the bovine cytoplasmic tail is the shortest thus far analyzed. Aligning the known FcRn sequences, we noted that the bovine protein shows a 3-aa deletion compared to the rat and mouse sequences in the α1 loop. Furthermore, we found a shorter transcript of the bFcRn reflecting an exon 6-deleted mRNA, which results from an inadequate splice acceptor site in intron 5 and produces a transmembrane-deficient molecule, as was previously demonstrated in the related MHC class I gene family in mouse and humans. The presence of bFcRn transcripts in multiple tissues, including the mammary gland, suggests their involvement both in IgG catabolism and transcytosis.

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Section: Bovine Igg Metabolismmentioning

confidence: 77%

Cloning and Characterization of the Bovine MHC Class I-Like Fc Receptor

Kacskovıcs

Simister

et al. 2000

The Journal of Immunology

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“…A redução na concentração sérica de imunoglobulinas durante o período pré-parto, observada em bovinos, está associada à remoção ativa desses anticorpos pela glândula mamária (Larson & Kendall, 1957;Sasaki et al, 1976). Em bovinos nas três últimas semanas pré-parto, pesquisadores têm observado mobilização de 500 a 700 g de imunoglobulinas do sangue para a glândula mamária (Dixon et al, 1961;Brandon & Lascelles, 1971;Foley & Otterby, 1978).…”

Section: Resultsunclassified

Flutuação das variáveis séricas em cabras e estudo comparativo da absorção de anticorpos em cabritos recém-nascidos utilizando colostro bovino e caprino

et al. 2009

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RESUMO -Objetivou-se determinar a flutuação no nível de anticorpos séricos em cabras nos períodos pré e pós-parto e a eficiência do processo de aquisição de imunidade passiva em cabritos recém-nascidos utilizando colostros bovino e caprino, visando à avaliação de uma alternativa de manejo de colostro. Foram utilizadas 18 cabras e suas respectivas crias, num total de 33 animais. A coleta de sangue das cabras foi iniciada 45 dias antes da data prevista para o parto e foi realizada em intervalos de cinco dias até o 5 o dia após o parto. Os cabritos foram distribuídos em dois grupos: um grupo recebeu colostro caprino e o outro colostro bovino. As coletas de sangue foram feitas às 0, 12, 24 e 48 horas e aos 5, 10, 15, 17, 20, 25, 30, 35, 40, 50 e 60 dias de vida. Foram analisadas as concentrações séricas de proteína total e imunoglobulinas, além da concentração de imunoglobinas no colostro. O delineamento experimental foi o inteiramente casualizado e as variáveis séricas analisadas como medidas repetidas. A ausência de queda na concentração sérica de proteínas totais e imunoglobinas no período pré-parto indica que a mobilização de anticorpos para glândula mamária ocorre em concentrações que permitem o animal manter essas variáveis sem grandes alterações. No grupo que recebeu colostro bovino, a data de concentração máxima de proteínas totais (7,16 ± 0,28 g/dL)foi verificada às 48,68 ± 0,70 horas de vida e a de imunoglobinas, às 48,75 ± 0,73 horas, com média de 37,56 ± 2,38 unidades ZST (turvação por sulfato de zinco). No grupo que recebeu colostro caprino, os valores máximos de proteínas totais e imunoglobinas séricas ocorreram mais tardiamente, aos 20,05 ± 1,36 e 20,11 ± 1,72 dias de vida, com médias de 5,91 ± 0,22 g/dL e 28,17 ± 2,05 unidades ZST, respectivamente. O colostro caprino pode ser substituído pelo colostro bovino, que promove melhor aquisição inicial de imunoglobulinas aos neonatos.Palavras-chave: imunoglobulinas, pequenos ruminantes, proteína sérica, Saanen Fluctuation of serum variables in goats and comparative study of antibody absorption in new-born kids using cattle and goat colostrumABSTRACT -The objective of this study was to determine the fluctuation of serum antibodies in goats in the period before and immediately after kidding and the passive immunity acquisition efficiency in kids fed bovine and goat colostrum, to assess an alternative for colostrum management. Eighteen goats and their offspring were used in a total of 33 animals. Goat blood samples started to be collected 45 days before the predicated kidding date, at five-day intervals until the 5 th day post kidding. The kids were distributed in two groups: one group received goat colostrum and the other cattle colostrums. Blood collections were made 0, 12, 24 and 48 hours, and at 5, 10, 15, 17, 20, 25, 30, 40, 50 and 60 days of age. The serum concentration of total protein (TP) and immunoglobulins (Ig), and the colostrum IgG concentration were analyzed. A randomized complete design was used and the serum variables were analyzed as repea...

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“…This transport system explains the very different ratio between IgGl/ IgG2 in colostrum and plasma. Fixation sites with a very high affinity (Sasaki et al, 1977) for IgG have been clearly identified on the basal membranes of glandular epithelium cells (Brandon and Lascelles, 1971;Hammer and Mossman, 1978). These cells proliferate during the period of mammary growth preceding parturition and their growth is affected by oestradiol 17-beta (Delouis, 1978).…”

Section: Origin Of Colostral Antibodiesmentioning

confidence: 99%

“…In ungulates, the IgG are predominantly IgGl. In the cow, 85% of total colostrum Ig are IgG with 95% IgGl and only 5% IgG2 (review by Berthon and Salmon, 1993) whereas, in the blood the IgG are much more balanced, 55 and 45%, respectively (Brandon and Lascelles, 1971;Beer et al, 1974). In pig colostrum as opposed to cow's, IgG are only twice as abundant as IgA (Jensen and Pedersen, 1979).…”

Section: Type Of Colostral Antibodiesmentioning

confidence: 99%

Acquisition of passive immunity in domestic ungulates

Grongnet¹,

Duvaux-Ponter

1998

J. Anim. Feed Sci.

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The ungulates possess an epteriochondrial placenta, which separates the maternal and foetal blood systems and thus reduces the permeability of the placenta to small molecules. Thus, in these species, the colostral imminoglobulins are the main source of protection factors which aid survival in the first days of life. This review deals with several aspects of passive immunity in ungulate neonates: the type and the origin of colostral immunoglobulins and factors which influence their production in the mother and their absorption form the gastrointestinal tract of the neonate.Recommendations for farmes to enhance natural postnatal immunity and recent technological advances in the production of immunoglobulin preparations are discussed.

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RELATIVE EFFICIENCY OF ABSORPTION OF IgG₁ IgG₂, IgA AND IgM IN THE NEWBORN CALF

Cited by 32 publications

References 2 publications

Cloning and Characterization of the Bovine MHC Class I-Like Fc Receptor

Cloning and Characterization of the Bovine MHC Class I-Like Fc Receptor

Flutuação das variáveis séricas em cabras e estudo comparativo da absorção de anticorpos em cabritos recém-nascidos utilizando colostro bovino e caprino

Acquisition of passive immunity in domestic ungulates

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RELATIVE EFFICIENCY OF ABSORPTION OF IgG1 IgG2, IgA AND IgM IN THE NEWBORN CALF

Cited by 32 publications

References 2 publications

Cloning and Characterization of the Bovine MHC Class I-Like Fc Receptor

Cloning and Characterization of the Bovine MHC Class I-Like Fc Receptor

Flutuação das variáveis séricas em cabras e estudo comparativo da absorção de anticorpos em cabritos recém-nascidos utilizando colostro bovino e caprino

Acquisition of passive immunity in domestic ungulates

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RELATIVE EFFICIENCY OF ABSORPTION OF IgG₁ IgG₂, IgA AND IgM IN THE NEWBORN CALF