Relative Enterotoxigenicity of Coliform Bacteria

Klipstein, Frederick A.; Engert, R F; Short, Helen B.

doi:10.1093/infdis/136.2.205

Cited by 23 publications

(27 citation statements)

References 49 publications

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“…Entenc Gram-negatives other than Escli. t o l i have recently been 5hown to cause diarrhoea in infants and children through the production of enterotoxin (19,28). Some of these bacteria may also have invasive properties (26).…”

Section: Discussionmentioning

confidence: 99%

Bacterial Meningitis in Childhood in an African City

Hailemeskel

Tafari

1978

Acta Paediatrica

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In a retrospective study of 120 children aged 1 month and above with bacterial meningitis confirmed by positive CSF culture, 88.4% were found to be due to three common organisms: H. influenzae, Str. pneumoniae and N. meinigitidis. Gram-negative enteric organisms accounted for 10% of the infections. Despite intensive antibiotic and ancillary therapy, there has been no significant change in case fatality and sequelae over the past decade in this institution. The present study confirms that factors related to the organism and the host are important in determining the outcome of therapy. H. influenzae and Str. pneumoniae infections are associated with statistically significant rise in case fatality rate and neurologic sequelae at the end of therapy. The presence of neurological abnormality at the time of diagnosis significantly increases case fatality rate while delay in diagnosis appears to primarily influence the frequency of neurological sequelae. Protein-energy malnutrition increases the frequency of neurological sequelae and death from bacterial meningitis without significantly influencing the pattern of bacterial aetiology. The finding of enteric Gram-negative meningitis in association with diarrhoeal disease in the present study adds a new dimension to one of the most prevalent health problems in developing countries and needs to be confirmed.

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Section: Discussionmentioning

confidence: 99%

Bacterial Meningitis in Childhood in an African City

Hailemeskel

Tafari

1978

Acta Paediatrica

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“…They thus fail below levels accepts by most as definitely positive (< 0-080). At best they can thus only be classified as having some lesser degree of toxigenicity (Klipstein, Engert & Short, 1977;Goldwater, 1979).…”

Section: Resultsmentioning

confidence: 99%

Escherichia coliin gastroenteritis of children in Auckland, New Zealand

Goldwater¹,

Bettelheim²,

Rb³

1981

J. Hyg.

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SUMMARYA study of stool Escherichia coli in 60 children with gastroenteritis and 18 control children was carried out in Auckland, New Zealand in 1977. Toxigenic strains, heat labile and heat stable, predominated in the stools ofonly three children, all ofwhom had concomitant rotavirus. Classical enteropathogenic E. coli (EPEC) were found in patients and controls. Only one patient had many EPEC in the stool (086. H2), they were variably toxigenic and rotavirus was also present. No toxigenic serotype was isolated. Two potential pathogens were sometimes found. Overall there was no evidence for a substantial causative role for disease producing E. coli in these children.

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“…0800 indicating a low level of ST production. From the work of Klipstein, Engert and Short, 1977, relative degrees of enterotoxigenicity seem to occur amongst toxigenic enterobacteriaceae. Whether or not the weakly ST+ strains found in this study produced the symptoms in those patients with gastroenteritis remains to be seen.…”

Section: Discussionmentioning

confidence: 99%

“…The mean ratios of strains H10407 and B7a were significantly different (P < 0.001). This suggests that these differences are true and that the idea of degrees of toxigenicity thus can be entertained (Klipstein, Engert and Short, 1977). The mean ratio of test strains regarded as being ST+ was 0.0736 (range 0.0701 to 0" 0793, standard deviation _+ 0.0025) being significantly greater than that of the control ST negative strain U5/41 (P < 0.001).…”

Section: Interpertation Of Gut Weight/remaining Body Weight Ratiosmentioning

confidence: 90%

Gastroenteritis in Auckland: An aetiological and clinical study

Goldwater

1979

Journal of Infection

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Faecal specimens from 60 patients (under six years old), most of whom were Maoris and Pacific Islanders admitted to Auckland Hospital with gastroenteritis during the months of June and July 1977, were examined for the presence of faecal viruses, bacterial pathogens and parasites. Faecal specimens from 18 non-diarrhoeal control patients were also examined, of which three contained rotavirus. Forty-three (72 per cent) gastroenteritis patients had rotavirus detectable in stools by electron microscopy or immune electron microscopy. Of the remainder, 17 patients were regarded as having non-rotavirus diarrhoea. Enterotoxigenic Esch. coli. was isolated from seven patients of whom six yielded stable toxin producers (ST+), four labile toxin producers (LT+) and two dual toxigenic strains (ST+/LT+). All ST+ isolates appeared to be of low enterotoxigenicity as indicated by low gut weight/carcass weight ratios in the infant mouse assay.Rotavirus was the commonest aetiological agent (72 per cent), bacterial pathogens (alone) accounted for only five per cent and no enteric pathogens were found in 15 per cent of cases. Non-agglutinable rotavirus, presumably a different serotype, was seen in both gastroenteritis and control patients. Rotavirus 'satellite' particles previously undescribed were demonstrated in a number of stool samples.

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Relative Enterotoxigenicity of Coliform Bacteria

Cited by 23 publications

References 49 publications

Bacterial Meningitis in Childhood in an African City

Bacterial Meningitis in Childhood in an African City

Escherichia coliin gastroenteritis of children in Auckland, New Zealand

Gastroenteritis in Auckland: An aetiological and clinical study

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