We prove the local well-posedness for the barotropic compressible Navier-Stokes system on a moving domain, a motion of which is determined by a given vector field V, in a maximal Lp − Lq regularity framework. Under additional smallness assumptions on the data we show that our solution exists globally in time and satisfies a decay estimate. In particular, for the global well-posedness we don't require exponential decay or smallness of V in Lp(Lq). However, we require exponential decay and smallness of its derivatives.