Relative hydrophobicity and lipophilicity of drugs measured by aqueous two-phase partitioning, octanol-buffer partitioning and HPLC. A simple model for predicting blood–brain distribution

A comparative investigation of methods for logistic regression with separated or nearly separated data

“…In comparison, SAS/PROC IML needed 2.1 s to compute penalized maximum likelihood estimates and PPL confidence intervals. Penalized maximum likelihood logistic regression has already been applied for the analysis of various medical studies [21,[29][30][31][32][33]. These studies and others, which have not yet been published, and the analysis of the examples provided by the present paper confirm the penalized maximum likelihood approach to be an easy-to-use method in the analysis of logistic regression problems when conventional asymptotic methods are in doubt and exact results are unavailable or unnecessarily conservative.…”

The opposite effect of temperature on polyethylene glycol-based aqueous biphasic systems versus aqueous biphasic extraction chromatographic resins

“…Distribution coefficients of molecules in an ABS may also represent an alternative to K ow (or log P, the partition coefficient in an octanol-water system) which is often used to predict bioavailability, bioconcentration, and transport of pharmaceuticals in biological systems [19,20]. ABS may be characterized by a phase diagram constructed from the component compositions of PEG and salt required to induce biphase formation.…”

Benzo-Fused Seven- and Six-Membered Derivatives Linked to Pyrimidines or Purines Induce Apoptosis of Human Metastatic Breast Cancer MCF-7 Cells In Vitro

“…e The experimental log P value is -0.83 (Buur et al, 1985). f The experimental log P value, measured by the octanol-buffer partitioning technique at pH 7.4 is -0.36  0.5 (Gulyaeva et al, 2003). Table 1.…”