Relative impact of low-density lipoprotein-cholesterol concentration and insulin resistance on carotid wall thickening in nondiabetic, normotensive volunteers

Wang, Pei Wen; Liou, Chia Wei; Wang, Shan Tair; Eng, Hock Liow; Liu, Rue Tsuan; Tung, Shih-Chen; Chien, Wei-Ming; Lu, Yung Chuan; Kuo, Ming Chun; Hsieh, Ching Jung; Chen, Cheng Hsiung; Chen, Jung Fu; Chu, James W.; Reaven, Gerald M.

doi:10.1053/meta.2002.29998

Cited by 13 publications

(11 citation statements)

References 41 publications

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“…20,21 IMT was found to correlate with LDL-C and triglyceride and to correlate inversely with HDL-C. 13 In the fasting state, LDL-C, but not HDL-C and plasma triglycerides, was related to IMT in 50-year-old white men. 22 Lp(a) was also suggested as a risk factor for carotid atherosclerosis.…”

Section: Potential Role Of Lipoprotein Metabolism In Carotid Atheroscmentioning

confidence: 94%

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Early-Onset Carotid Atherosclerosis Is Associated With Increased Intima-Media Thickness and Elevated Serum Levels of Inflammatory Markers

Magyar

Szikszai

Balla

et al. 2003

Stroke

132

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Background and Purpose-Several factors have been held responsible for the development of atherosclerosis. To avoid the masking effect of age, we evaluated correlates of carotid atherosclerosis in patients Ͻ55 years of age. Methods-Plasma lipids, oxidative resistance of low-density lipoprotein, homocysteine, inflammatory markers, plasma viscosity, and red cell deformability were measured in fasting blood samples of 100 subjects: 45 patients with Ͼ30% stenosis of the internal carotid artery, 20 patients with carotid occlusion, and 35 control subjects. Stenosis and intima-media thickness (IMT) of the carotid artery were evaluated by duplex ultrasound. Results-White blood cell (WBC) count, plasma fibrinogen, C-reactive protein (CRP), and lipoprotein(a) levels were significantly higher in patients than in control subjects, and patients had increased IMT (PϽ0.01 for all comparisons). There was a tendency for higher homocysteine levels in patients. Smokers had higher WBC, fibrinogen, and CRP levels. After the effect of smoking was controlled for, WBC count, natural logarithmic transform of homocysteine, and online-measured IMT remained significantly higher in patients than in control subjects. WBC, fibrinogen, and CRP levels were highest in the highest IMT quartile (Pϭ0.012, Pϭ0.007, and Pϭ0.036, respectively). Conclusions-Inflammatory markers and homocysteine have a more important role than lipid factors in early-onset carotid atherosclerosis. We cannot recommend the measurement of low-density lipoprotein peroxidation as a routine screening test to identify high-risk patients for early-onset carotid atherosclerosis. The confounding effect of smoking on inflammatory markers should be considered in studies on atherosclerosis.

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Section: Potential Role Of Lipoprotein Metabolism In Carotid Atheroscmentioning

confidence: 94%

“…11 In addition, we checked previously described alterations because high plasma homocysteine concentrations were reported to be associated with an increased risk of extracranial carotid artery sclerosis in the elderly, 12 and lipid levels were also found to correlate with IMT. 13 …”

mentioning

confidence: 99%

Early-Onset Carotid Atherosclerosis Is Associated With Increased Intima-Media Thickness and Elevated Serum Levels of Inflammatory Markers

Magyar

Szikszai

Balla

et al. 2003

Stroke

132

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“…There are also a number of previous reports linking certain lifestyles and traits, such as high cholesterol, smoking and diabetes to CIMT and the reliability of using carotid thickening as an indicator of impending blood pressure and cardiovascular problems has a sound basis [23]- [26]. Our hope is that this relatively cheap and safe technology, when combined with blood pressure readings and lipid measurements, also cheap and safe, can be used as an indicator that early intervention is required for patients with these risk factors.…”

Section: Discussion and Study Limitationsmentioning

confidence: 99%

A Cross-Sectional Survey to Determine the Prevalence of Cardiovascular Disease Risk Factors in an Understudied Population in Sierra Leone

Strasserking¹,

Bick²,

Russell³

et al. 2016

WJCD

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To document the prevalence of risk factors for cardiovascular disease in an unstudied community, a survey of 130 participants from different areas of Sierra Leone was performed. The focus was on cardiovascular disease because its prevalence had not been studied and World Health Organization (WHO) reports on Non-Communicable Diseases (NCD) prevalence were extrapolations and not from actual data. Resting blood pressure, fasting blood glucose, fasting lipid levels and carotid intima media thickness (CIMT) were measured. Mean blood pressure in men was slightly lower than in women (132/87 mmHg and 139/90 mmHg respectively), mean fasting blood glucose levels were <100 mg/dL in both groups and mean fasting total cholesterol was higher in women than in men (206 mg versus 193.5 mg/dL). Mean fasting low density lipoprotein levels were similar in both groups, 129 mg/dL in men and 133 mg/dL in women. Mean fasting high density cholesterol was 47.2 mg/dL in men and 55.5 mg/dL in women and CIMT values were similar in both groups, with 60% above the 75 th percentile. This study demonstrated a prevalence of cardiovascular risk factors in this population with mean BP placing both men and women in pre-hypertension or stage 1 hypertension ranges and elevated mean low density lipoprotein levels. Fasting total cholesterol, blood glucose and high density lipoprotein were within normal ranges. Mean CIMT values for men and women placed them at risk for subclinical atherosclerosis.

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“…The study by Laakso et al was the first to show reduced insulin sensitivity by euglycemic hyperinsulinemic clamp in nonobese, nondiabetic subjects with asymptomatic atherosclerosis, along with increased intimal-medial thickness (IMT), compared with control subjects (6). Subsequent studies mainly in non-diabetic subjects including those with hypertension or angina demonstrated complex outcomes concerning the association of IMT of the carotid artery with insulin resistance; significant (7)(8)(9)(10), partially significant, that is, significant in univariate but not in multivariate analysis (11)(12)(13)(14)(15), or nonsignificant (16,17). In type 2 diabetic patients, two studies found an inverse association of IMT of carotid artery with insulin resistance (18,19), but another did not (20).…”

Section: Introductionmentioning

confidence: 99%

Arterial Wall Thickness is Associated with Insulin Resistance in Type 2 Diabetic Patients

Fujiwara

Emoto

Komatsu

et al. 2003

J Atheroscler Thromb

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The aim of the present study was to investigate the independent association of the intimal-medial thickness of carotid and femoral arteries (CA-IMT and FA-IMT), a marker of atheroscelosis, with insulin resistance in type 2 diabetic patients. We evaluated CA-IMT and FA-IMT by high-resolution ultrasonography and insulin resistance determined by euglycemic hyperinsulinemic clamp in 119 type 2 diabetic subjects, 71 males and 48 females (

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Relative impact of low-density lipoprotein-cholesterol concentration and insulin resistance on carotid wall thickening in nondiabetic, normotensive volunteers

Cited by 13 publications

References 41 publications

Early-Onset Carotid Atherosclerosis Is Associated With Increased Intima-Media Thickness and Elevated Serum Levels of Inflammatory Markers

Early-Onset Carotid Atherosclerosis Is Associated With Increased Intima-Media Thickness and Elevated Serum Levels of Inflammatory Markers

A Cross-Sectional Survey to Determine the Prevalence of Cardiovascular Disease Risk Factors in an Understudied Population in Sierra Leone

Arterial Wall Thickness is Associated with Insulin Resistance in Type 2 Diabetic Patients

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