1994
DOI: 10.1016/0360-3016(94)90278-x
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Relative importance of DT-diaphorase and hypoxia in the bioactivation of e09 by human lung tumor cell lines

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Cited by 48 publications
(22 citation statements)
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“…A significant correlation was found between the level of DTdiaphorase activity and sensitivity to MMC and E09 in the human tumour cell lines of the National Cancer Institute Tumour Cell Line Panel (Fitzsimmons et al, 1996). E09 activity appears to be particularly sensitive to the level of DT-diaphorase under oxygenated conditions (Plumb et al, 1994). Increasing DTdiaphorase activity in gastric carcinoma (Mikami et al, 1996) or Chinese hamster ovary cells (Belcourt et al, 1996), by transfection of the NQO, gene, increased the sensitivity of the cells to MMC.…”
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confidence: 91%
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“…A significant correlation was found between the level of DTdiaphorase activity and sensitivity to MMC and E09 in the human tumour cell lines of the National Cancer Institute Tumour Cell Line Panel (Fitzsimmons et al, 1996). E09 activity appears to be particularly sensitive to the level of DT-diaphorase under oxygenated conditions (Plumb et al, 1994). Increasing DTdiaphorase activity in gastric carcinoma (Mikami et al, 1996) or Chinese hamster ovary cells (Belcourt et al, 1996), by transfection of the NQO, gene, increased the sensitivity of the cells to MMC.…”
mentioning
confidence: 91%
“…DT-diaphorase has been shown to be an important activating enzyme for bioreductive anti-tumour agents, such as mitomycin C (MMC) (Begleiter et al, 1989;Ross et al, 1993;Mikami et al, 1996), 3-hydroxymethyl-5-aziridinyl-l-methyl-2(1H-indole-4,7-dione)prop-,B-en-a-ol (EO9) (Plumb et al, 1994), diaziquone (Siegel et al, 1990), streptonigrin (Beall et al, 1996) and others (Workman and Stratford, 1993) in many systems. Bioreductive agents require intracellular activation by either two-electronreducing enzymes, such as DT-diaphorase (Ross et al, 1993;Plumb et al, 1994) and xanthine dehydrogenase (EC 1.1.1.204) (Gustafson and Pritsos, 1992) or by one-electron-reducing enzymes, such as NADPH:cytochrome P450 reductase (EC 1.6.2.4) (Pan et al, 1984) and NADH:cytochrome b5 reductase (EC 1.6.2.2) (Hodnick and Sartorelli, 1993).…”
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confidence: 99%
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“…DT-diaphorase plays an important role in activating bioreductive anti-tumour agents like MMC (Begleiter et al, 1989;Ross et al, 1993;Mikami et al, 1996;Nishiyama et al, 1997), EO9 (Plumb ξ€…ξ€™ξ€•ξ€ξ€™ξ€‘ξ€“ξ€’ξ€€ξ€‘ξ€’ξ€žξ€šξ€žξ€šξ€‘ξ€–ξ€‘ξ€–ξ€žξ€’ξ€€ξ€šξ€”ξ€€ξ€˜ξ€–ξ€žξ€šξ€˜ξ€’ξ€‘ξ€–ξ€™ξ€€ξ€ƒξ€€ξ€–ξ€™ξ€€ξ€•ξ€Ÿξ€˜ξ€ξ€™ξ€€ξ€žξ€Ÿξ€˜ξ€šξ€Ÿξ€œ ξ€‘ξ€“ξ€—ξ€—ξ€ξ€€ξ€ ξ€–ξ€žξ€•ξ€€ξ€–ξ€™ξ€’ξ€Ÿξ€‘ξ€“ξ€œξ€ξ€€ξ€šξ€”ξ€€ξ€„ξ€Žξ€ξ€’ξ€–ξ€ξ€›ξ€•ξ€šξ€œξ€ξ€ξ€“ et al, 1994), streptonigrin (Beall et al, 1996) and RH1 (Winski et al, 1998). Cell lines with high levels of DT-diaphorase are more sensitive to MMC (Begleiter et al, 1989;Ross et al, 1993;Mikami et al, 1996), and studies have shown a good correlation between the level of DT-diaphorase activity and the sensitivity to MMC in human tumour cell lines (Fitzsimmons et al, 1996).…”
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confidence: 99%
“…Several studies have been published recently, in which a correlation was postulated between the DTD levels (both expression and activity) and the chemosensitivity to E09 under normoxic conditions (Robertson et al, 1992;Walton et al, 1992b;Plumb et al, 1994a;Smitskamp-Wilms et al, 1994). For other reductive enzymes such as the one-electrondonating NADH cytochrome b5 reductase (Cb5R) and NADPH cytochrome P450 reductase (CP450R) no such relation with E09 sensitivity was found in more than 20 human tumour cell lines (Ross et al, 1993;Plumb et al, 1994a,c).…”
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confidence: 99%