Relative insulin insensitivity and cortisol secretion in depressed patients

Nathan, Rajan; Sachar, Edward J.; Asnis, Gregory M.; Halbreich, Uriel; Halpern, Frieda S.

doi:10.1016/0165-1781(81)90031-7

Cited by 67 publications

(25 citation statements)

References 29 publications

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“…Additional direct physiological mechanisms, which have particular relevance for type 2 diabetes, relate to the reduction of glucose use and to the increase of insulin resistance. Both mechanisms have been found in depressed individuals without diabetes (39)(40)(41).…”

Section: Presence Of Other Atypical Features (Absence Of Family Histomentioning

confidence: 99%

A review of the relationship between depression and diabetes in adults: is there a link?

2000

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A Review of the Relationship Between Depression and Diabetes in AdultsIs there a link?OBJECTIVE -To review the support for two hypotheses concerning the interrelationship between depression and diabetes and to identify areas in which more research is needed.RESEARCH DESIGN AND METHODS -A review was conducted using primarily electronic databases. Articles relating to diabetes and depressive symptomatology, depressive disorder, and dysthymic disorder were selected. The study focuses mainly on adults with diabetes.RESULTS -The initial onset of major depressive disorder (MDD) seems to be independent of the onset of type 2 diabetes, but results remain equivocal for type 1 diabetes. However, in both type 1 and type 2 diabetes, diabetes-related psychological and physiological processes may be involved in the higher recurrence and longer duration of MDD and depressive symptomatology.CONCLUSIONS -The hypotheses that the initial occurrence of clinically significant depression, MDD, results from either biochemical changes directly due to type 2 diabetes or its treatment or from the psychosocial demands imposed by the illness or its treatment do not seem to be supported. MDD in diabetic individuals represents a multidetermined phenomenon resulting from interactions between biologic and psychosocial factors. This interaction may increase the probability of developing type 2 diabetes in otherwise healthy individuals. Diabetes R e v i e w s / C o m m e n t a r i e s / P o s i t i o n S t a t e m e n t s

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Section: Presence Of Other Atypical Features (Absence Of Family Histomentioning

confidence: 99%

A review of the relationship between depression and diabetes in adults: is there a link?

2000

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“…In addition, others found a higher incidence of diabetes in depressed versus non-depressed subjects (0.72% vs. 0.47% yearly), with unadjusted and adjusted risk (95% CI) of 1.56 (1.37-1.77) and 1.38 (1.23-1.55), respectively (both P values <0.001) [5,6]. Depression could facilitate the onset of diabetes through multiple mechanisms, including depression-related factors known to increase insulin resistance such as disturbances in eating behaviors and physical inactivity, antidepressant medication use and weight gain, or stimulation of stress-related hormonal pathways and pro-inflammatory cytokines which interfere with glucose metabolism [7][8][9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Prevalence, Gender Differences and Associated Factors of Depression among Adults with Type 2 Diabetes, Jordan

Hyassat¹,

Al-Doseri²,

Hashem³

et al. 2017

J Depress Anxiety

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“…Patients with depression have exhibited glucose intolerance accompaniedby elevated serum insulin levels after oral glucose load (3,4), as well as reduced glucose responsiveness to exogenous insulin during the insulin tolerance test (5). These findings suggest the occurrence of increased insulin resistance in patients with depression.…”

Section: Introductionmentioning

confidence: 63%

Insulin Resistance in Patients with Depression and its Changes in the Clinical Course of Depression: A Report on Three Cases Using the Minimal Model Analysis.

et al. 1999

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It has been reported that depression and diabetes mellitus often occur together, and insulin resistance has been observed in patients with depression. For further understanding of the relationship of depression to insulin resistance, three patients with depression were given the oral glucose tolerance test (OGTT) and the frequently sampled intravenous glucose tolerance test (FSIGT) with minimal model analysis before and after antidepressant treatment. Depressive patients showed decreased glucose tolerance, enhanced insulin secretion, and diminished insulin sensitively during OGTT and FSIGT. These abnormalities were resolved after their recovery from depression without changes in body weight or diet. (Internal Medicine 38: 257-260, 1999)

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Relative insulin insensitivity and cortisol secretion in depressed patients

Cited by 67 publications

References 29 publications

A review of the relationship between depression and diabetes in adults: is there a link?

A review of the relationship between depression and diabetes in adults: is there a link?

Prevalence, Gender Differences and Associated Factors of Depression among Adults with Type 2 Diabetes, Jordan

Insulin Resistance in Patients with Depression and its Changes in the Clinical Course of Depression: A Report on Three Cases Using the Minimal Model Analysis.

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