Relative localizing value of amygdalo-hippocampal MR biometry in temporal lobe epilepsy

Pereira, Pedro Gonçalves; Oliveira, Eduardo De; Rosado, Pedro

doi:10.1016/j.eplepsyres.2006.01.012

Cited by 16 publications

(11 citation statements)

References 48 publications

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“…It may be due to high Cho elevation in the early gliotic process of the hippocampus before evident signal intensity changes. NAA/(Cho+Cr) showed no relationship with volumetry, concordant with previous comparative reports [14, 15, 17]. MRS should be performed with chemical shift imaging (CSI) multivoxel spectroscopy.…”

Section: Discussionsupporting

confidence: 90%

“…MRS should be performed with chemical shift imaging (CSI) multivoxel spectroscopy. In both single-voxel spectroscopy (SVS) and CSI studies on TLE the lateralization ratios were reported to be similar to NAA/(Cho+Cr) ratios [17, 30–32]. Hsu et al compared SVS with CSI in patients with complex partial seizures and also reported similar NAA/(Cho+Cr) ratios [33].…”

Section: Discussionmentioning

confidence: 98%

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Comparative Lateralizing Ability of Multimodality MRI in Temporal Lobe Epilepsy

et al. 2016

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Purpose. The objective is to compare lateralizing ability of three quantitative MR (qMRI) modalities to depict changes of hippocampal architecture with clinical entities in temporal lobe epilepsy. Methods. We evaluated 14 patients with clinical and EEG proven diagnosis of unilateral TLE and 15 healthy volunteers. T1-weighted 3D dataset for volumetry, single-voxel 1H MR spectroscopy (MRS), and diffusion tensor imaging (DTI) were performed for bilateral hippocampi of all subjects. Results. Individual volumetric measurements provided accurate lateralization in 85% of the patients, spectroscopy in 57%, and DTI in 57%. Higher lateralization ratios were acquired combining volumetry-spectroscopy (85%), spectroscopy-DTI (85%), and volumetry-DTI (100%). Significantly decreased NAA/(Cho+Cr) ratios (p = 0.002) and increased FA (p = 0.001) values were obtained in ipsilateral to epileptogenic hippocampus. Duration of epilepsy and FA values showed a significant negative correlation (p = 0.016, r = −0.847). The history of febrile convulsion associated with ipsilateral increased ADC values (p = 0.015, r = 0.851) and reduced NAA/(Cho+Cr) ratios (p = 0.047, r = −761). Conclusion. Volumetry, MRS, and DTI studies provide complementary information of hippocampal pathology. For lateralization of epileptogenic focus and preoperative examination, volumetry-DTI combination may be indicative of diagnostic accuracy.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 98%

Comparative Lateralizing Ability of Multimodality MRI in Temporal Lobe Epilepsy

et al. 2016

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“…In neurophysiological studies using intracerebral recordings, 5% of MTLE patients had seizure onset in the amygdala 4. In previously reported imaging studies, isolated unilateral amygdala damage determined by either reduced volume or prolonged T2 relaxation time was observed in 8% of MTLE patients 5. Therefore, the amygdala may not only be involved and affected in MTLE but may also be regarded as an independent cause of MTLE.…”

Section: Introductionmentioning

confidence: 93%

Amygdalar enlargement in patients with temporal lobe epilepsy

Mitsueda-Ono

Ikeda

Inouchi

et al. 2010

Journal of Neurology, Neurosurgery & Psychiatry

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“…A neurophysiological study using intracranial recordings showed that 5% of mesial TLE (MTLE) patients had seizure onset in the amygdala [ 9 ]. Previous imaging studies reported that isolated unilateral amygdala damage was observed in about 8% of MTLE patients [ 10 ]. Therefore, the amygdala may not only be involved and affected in MTLE but may also be regarded as an epileptogenic focus of MTLE.…”

Section: Introductionmentioning

confidence: 99%

Temporal lobe epilepsy with amygdala enlargement: a subtype of temporal lobe epilepsy

Sun

Tao

et al. 2014

BMC Neurol

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BackgroundSome recent studies suggest that some imaging-negative temporal lobe epilepsy (TLE) had significant amygdala enlargement (AE). Contradictory data were also reported in previous studies regarding the association between AE and TLE. The present study was to investigate the clinical characters of a group of TLE with AE and compare the amygdala volume of the same patient before and after antiepileptic drugs treatment by a larger sample size.MethodsThis study recruited 33 mesial TLE patients with AE and 35 healthy volunteers. The clinical history, seizure semiology, electroencephalogram (EEG), fluorodeoxyglucose-positron emission tomography (FDG-PET) and amygdala volume were investigated. The amygdala volume were compared between ipsilateral and contralateral sides, TLE patients and 35 healthy controls, and patients at first and follow-up visit by 3.0 T MRI.ResultsAverage seizure onset age was 42.0 years (SD 14.3). All patients had complex partial seizures, fourteen had occasional generalized tonic-clonic seizures which often happened during sleep. Ninety percent patients suffered from anxiety or depression. Thirty percent patients had memory decline. Interictal epileptiform discharges appeared predominantly in the anterior or inferior temporal area ipsilateral to AE. Interictal FDG-PET showed regional glucose hypometabolism in the ipsilateral temporal lobe. No hippocampal sclerosis (HS) was suspected in all patients. 22 patients demonstrated good seizure control and significantly reduced volume of the enlarged amygdala after treatment (P < 0.01). The other 11 patients showed initial response to treatment, followed by a gradual increase in seizure frequency over time, and no volume change of the enlarged amygdala after treatment.ConclusionsTLE with AE probably represents a distinct nosological and probably less homogeneous syndrome which is most likely a subtype of TLE without ipsilateral HS. The chronic and long lasting inflammatory processes or focal cortical dysplasia could lead to amygdala enlargement possibly.

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Relative localizing value of amygdalo-hippocampal MR biometry in temporal lobe epilepsy

Cited by 16 publications

References 48 publications

Comparative Lateralizing Ability of Multimodality MRI in Temporal Lobe Epilepsy

Comparative Lateralizing Ability of Multimodality MRI in Temporal Lobe Epilepsy

Amygdalar enlargement in patients with temporal lobe epilepsy

Temporal lobe epilepsy with amygdala enlargement: a subtype of temporal lobe epilepsy

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