Relative Polycation Interactions with Whole Bloos and Model Media

Domurado, Dominique; Moreau, Élisabeth; Chotard-Ghodsnia, Roxana; Ferrari, Isabelle; Chapon, Pascal; Vert, Michel

doi:10.1007/0-306-46842-5_13

Cited by 3 publications

(4 citation statements)

References 19 publications

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“…Using polyanions as protein carriers to resist viruses exhibit great immunoadjuvant activity, which was superior to inoculation method. For example, the primary antibody response to sheep erythrocytes has been enhanced using polyanions 19–21. Among various polyanions, PAA appears much higher antiviral activity and less cytotoxic than others (e.g.…”

Section: Introductionmentioning

confidence: 99%

Self‐assembly of bovine serum albumin and poly(acrylic acid) induced by noncovalent bonds

Wang

2012

J of Applied Polymer Sci

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Bovine serum albumin/poly(acrylic acid), BSA/PAA, nano-scaled particles were produced by noncovalent bonds induced self-assembly method at acid pH area. Proper conditions during preparation process, such as pH value, BSA/PAA weight ratio(WR), PAA molecular weight, were researched by studying the hydrodynamic diameter, polydispersity index, and f potential of the nanoparticles. Complex formation between BSA and PAA was studied by FT-IR, AFM, and TEM. BSA chains are supposed to be partly trapped in the nanoparticles core after interaction with PAA because of the electrostatic attractions and hydrogen bonds interactions between BSA and PAA, while the rest of the BSA chains should form the shell of the nanoparticles.

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Section: Introductionmentioning

confidence: 99%

Self‐assembly of bovine serum albumin and poly(acrylic acid) induced by noncovalent bonds

Wang

2012

J of Applied Polymer Sci

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“…Even if polyethylenimine (PEI) has been considered as the gold standard of non-viral vectors for several years, PDMAEMA has gained in popularity due to a high transfection efficiency combined with a lower cytotoxicity (Cerda-Cristerna et al, 2011;Dubruel et al, 2003;Robbens et al, 2010;Schallon et al, 2010). This safety aspect requires major attention for intravenous administration due to the well-known reactivity of the blood and the potential risk of ionic interaction of polycations with various negatively charged domains found on blood components such as RBCs or plasma proteins (Domurado et al, 2001).…”

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confidence: 99%

“…Because most blood proteins are anionic under physiological conditions, any circulating cationic macromolecule would most likely interact with plasma proteins. Through their rapid binding to polycations with formation of polyelectrolyte complexes, plasma proteins could significantly alter the affinity and selectivity of polycations for biological sites (Cerda-Cristerna et al, 2011;Domurado et al, 2001;Moreau et al, 2000).…”

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confidence: 99%

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In vitro study of the specific interaction between poly(2-dimethylamino ethylmethacrylate) based polymers with platelets and red blood cells

Flebus

Lombart

Martínez-Jothar

et al. 2015

International Journal of Pharmaceutics

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Bioresorbable polyelectrolyte amphiphiles as nanosized carriers for lipophilic drug solubilization and delivery

Domurado

Vert

2007

Journal of Biomaterials Science, Polymer Edition

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Starting from drug carriers and drug-delivery systems described in the literature, this article examines more specifically those that are relevant to the field of nanocarriers composed of a degradable hydrophilic polyelectrolyte backbone with pendent hydrophobes arranged to form comb-like co-polymers. Advantage is taken of the nanosized, lipophilic pocket-bearing multimolecule aggregates formed in aqueous media by such amphiphilic polyelectrolytes to accommodate water-insoluble drug molecules according to a phenomenon named macromolecular microencapsulation. Comments are also made on the criteria to be fulfilled by nanosized polymeric drug carriers. These carriers require a size or molar mass high enough to avoid renal excretion and thus be retained in the body for longer periods of time than the free drug. Since they nevertheless have to be eliminated from the body (bioresorption), they must be degraded at the end of use. In situ degradation is an important criterion that is taken into account by using special polyelectrolytes that belong to the class of the so-called "artificial biopolymers". Artificial biopolymers are made of pro-metabolite units than generate metabolite upon degradation, thus resulting in metabolisation of degradation end-products if intermediates are not excreted before. Aggregates of amphiphilic polyanions derived from malic acid, citric acid, L-lysine and L-serine are presented to support the concept of macromolecular microencapsulation. Comparison is made with non-polyelectrolytic systems with similar structures.

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Relative Polycation Interactions with Whole Bloos and Model Media

Cited by 3 publications

References 19 publications

Self‐assembly of bovine serum albumin and poly(acrylic acid) induced by noncovalent bonds

Self‐assembly of bovine serum albumin and poly(acrylic acid) induced by noncovalent bonds

In vitro study of the specific interaction between poly(2-dimethylamino ethylmethacrylate) based polymers with platelets and red blood cells

Bioresorbable polyelectrolyte amphiphiles as nanosized carriers for lipophilic drug solubilization and delivery

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