Relative preservation of MMSE scores in autopsy-proven dementia with Lewy bodies

Nelson, Peter T.; Jicha, Gregory A.; Abner, Erin L.; Schmitt, Frederick A.; Xu, Lingjia; Cooper, Gregory M.; Smith, Colin; Markesbery, William R.

doi:10.1212/wnl.0b013e3181bacf9e

Cited by 81 publications

(77 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Furthermore, since PiB imaging does not distinguish between amyloid-b deposition of diffuse more than neuritic plaques (Kantarci et al, 2012c), it is also not known whether this distinction may make a difference in the effects of amyloid protein aggregation in DLB, and may contribute to some of this variability. Overall our findings are in agreement with the hypothesis that patients with probable DLB with concomitant underlying Alzheimer's disease pathology could show a more aggressive clinical phenotype of the disease with increased atrophy rates and functional decline (Nelson et al, 2009;Clinton et al, 2010;Gomperts et al, 2012;De Beer et al, 2015;Ferman et al, 2015;Graff-Radford et al, 2015;Howlett et al, 2015).…”

Section: Discussionsupporting

confidence: 91%

“…In the Lewy bodies disease spectrum of disorders, autopsy studies highlighted that co-occurrence of amyloid-b plaques and phosphorylated tau together with -synuclein deposition are associated with greater cognitive decline (Kraybill et al, 2005;Nelson et al, 2009;Ferman et al, 2015;Howlett et al, 2015), and shorter survival (Kotzbauer et al, 2012;Graff-Radford et al, 2015) .…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Amyloid-β deposition and regional grey matter atrophy rates in dementia with Lewy bodies

Sarro¹,

Senjem

Lundt

et al. 2016

Brain

View full text Add to dashboard Cite

Alzheimer's disease pathology frequently coexists with Lewy body disease at autopsy in patients with probable dementia with Lewy bodies. More than half of patients with probable dementia with Lewy bodies have high amyloid-b deposition as measured with 11 C-Pittsburgh compound B binding on positron emission tomography. Biomarkers of amyloid-b deposition precede neurodegeneration on magnetic resonance imaging during the progression of Alzheimer's disease, but little is known about how amyloid-b deposition relates to longitudinal progression of atrophy in patients with probable dementia with Lewy bodies. We investigated the associations between baseline 11 C-Pittsburgh compound B binding on positron emission tomography and the longitudinal rates of grey matter atrophy in a cohort of clinically diagnosed patients with dementia with Lewy bodies (n = 20), who were consecutively recruited to the Mayo Clinic Alzheimer's Disease Research Centre. All patients underwent 11 C-Pittsburgh compound B positron emission tomography and magnetic resonance imaging examinations at baseline. Follow-up magnetic resonance imaging was performed after a mean (standard deviation) interval of 2.5 (1.1) years. Regional grey matter loss was determined on threedimensional T 1 -weighted magnetic resonance imaging with the tensor-based morphometry-symmetric normalization technique. Linear regression was performed between baseline 11 C-Pittsburgh compound B standard unit value ratio and longitudinal change in regional grey matter volumes from an in-house modified atlas. We identified significant associations between greater baseline 11 C-Pittsburgh compound B standard unit value ratio and greater grey matter loss over time in the posterior cingulate gyrus, lateral and medial temporal lobe, and occipital lobe as well as caudate and putamen nuclei, after adjusting for age (P 5 0.05). Greater baseline 11 C-Pittsburgh compound B standard unit value ratio was also associated with greater ventricular expansion rates (P 5 0.01) and greater worsening over time in Clinical Dementia Rating Scale, sum of boxes (P = 0.02). In conclusion, in patients with probable dementia with Lewy bodies, higher amyloid-b deposition at baseline is predictive of faster neurodegeneration in the cortex and also in the striatum. This distribution is suggestive of possible interactions among amyloid-b, tau and a-synuclein aggregates, which needs further investigation. Furthermore, higher amyloid-b deposition at baseline predicts a faster clinical decline over time in patients with probable dementia with Lewy bodies. Keywords: DLB; structural MRI; beta-amyloid; amyloid imaging; brain atrophy Abbreviations: AChEI = acetylcholinesterase inhibitor; CDR-SOB = Clinical Dementia Rating scale, Sum of Boxes; DLB = dementia with Lewy bodies; MMSE = Mini-Mental State Examination; PiB = 11 C-Pittsburgh compound B; SUVR = standardized uptake value ratio; TBM-SyN = tensor-based morphometry using symmetric diffeomorphic image normalization; UPDRS-III =

show abstract

Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Amyloid-β deposition and regional grey matter atrophy rates in dementia with Lewy bodies

Sarro¹,

Senjem

Lundt

et al. 2016

Brain

View full text Add to dashboard Cite

show abstract

“…Several studies have shown faster deterioration in DLB cases with co-morbid AD pathology as assessed through post-mortem analyses of amyloidbeta (A ) burden [22][23][24] . A typical AD cerebrospinal fluid (CSF) profile, defined as low A 42 alone or in combination with elevated tau and phosphorylated tau, have been shown to be significantly associated with a more rapid cognitive decline in DLB patients 25 (Figure 1), similar to findings in PD 26 .…”

Section: Cognitive Declinementioning

confidence: 99%

The prognosis of dementia with Lewy bodies

Mueller

Ballard

Corbett

et al. 2017

The Lancet Neurology

185

183

View full text Add to dashboard Cite

2 SummaryDementia with Lewy bodies (DLB) is the second most common form of neurodegenerative dementia and is distinct from Alzheimer's disease (AD) in symptomatology and pathology. Yet little is known about its prognosis and disease trajectories. These issues are critical to informing clinical practice and research. The literature indicates a less favourable prognosis in DLB, with reported accelerated cognitive decline, shorter lifespan and increased nursing home admission. Healthcare costs are also reported to be higher in DLB than AD. Importantly, caregiver burden is significantly higher in DLB. It is likely that causative factors in these issues include the higher prevalence, and earlier emergence, of neuropsychiatric symptoms in DLB and the challenge of accurate diagnosis. Evidence concerning quality of life and hospital admissions is extremely limited despite the importance of these issues.

show abstract

“…During autopsy (usually 5 or less hours after death), tissue samples including parietal cortex and cerebellum were processed for neuropathological evaluations or flash-frozen in liquid nitrogen and stored at -80°C, as described previously [53,54]. All included Dementia with Lewy Bodies subjects met the clinical and histopathological criteria for diagnosis of Dementia with Lewy Bodies [55]. The control subjects received Minimental State Examination scores ≥ 23 with Braak staging at ≤ 2.…”

Section: Introductionmentioning

confidence: 99%

Neurodegeneration-associated instability of ribosomal DNA.

Hallgren¹

View full text Add to dashboard Cite

Homologous recombination-mediated instability of the repetitively organized ribosomal DNA has been proposed as a mediator of cell senescence in yeast triggering the DNA damage response. High individual variability in the content of human ribosomal DNA suggests that this genomic region remained relatively unstable throughout evolution. Therefore, quantitative real time PCR was used to determine the genomic content of ribosomal DNA in post mortem samples of parietal cortex from 14 young and

show abstract

Relative preservation of MMSE scores in autopsy-proven dementia with Lewy bodies

Abstract: Background: Recent studies raised questions about the severity of cognitive impairment associ-

Cited by 81 publications

References 43 publications

Amyloid-β deposition and regional grey matter atrophy rates in dementia with Lewy bodies

Amyloid-β deposition and regional grey matter atrophy rates in dementia with Lewy bodies

The prognosis of dementia with Lewy bodies

Neurodegeneration-associated instability of ribosomal DNA.

Contact Info

Product

Resources

About