Relative prevalence of comorbidities and treatment contraindications in HIV-mono-infected and HIV/HCV-co-infected veterans

Goulet, Joseph L.; Fultz, Shawn L.; McGinnis, Kathleen A.; Justice, Amy C.

doi:10.1097/01.aids.0000192077.11067.e5

Cited by 106 publications

(103 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Depression and substance abuse have been previously reported to be more common in HCV-infected compared with HCV-uninfected persons and in HIVinfected persons compared with HIV-uninfected persons. 7,22,23 However, our study demonstrates and compares these comorbidities directly among HCV-infected patients cared for in tertiary care referral centers. Of note, rates of contraindications to HCV therapy due to hematological abnormalities (anemia, thrombocytopenia) were less common in the coinfected group.…”

Section: Discussionmentioning

confidence: 93%

Rates of HCV Treatment Eligibility Among HCV-Monoinfected and HCV/HIV-Coinfected Patients in Tertiary Care Referral Centers

Butt

Khan

Shaikh

et al. 2009

HIV Clinical Trials

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 93%

Rates of HCV Treatment Eligibility Among HCV-Monoinfected and HCV/HIV-Coinfected Patients in Tertiary Care Referral Centers

Butt

Khan

Shaikh

et al. 2009

HIV Clinical Trials

View full text Add to dashboard Cite

show abstract

“…For example, the sensitivity, specificity, agreement and k values have been reported as follows: N diabetes: sensitivity 64%; specificity 99.2%; agreement 95.8%; k = 0.72. 26 We did not determine how many untreated people were actually eligible for treatment. Treatment prescription was determined from pharmacy records, and whether the patients actually took any of the drugs prescribed is unknown.…”

Section: Discussionmentioning

confidence: 99%

Rate and predictors of treatment prescription for hepatitis C

Butt

Justice

Skanderson

et al. 2007

Gut

140

126

View full text Add to dashboard Cite

Background: The true treatment rate for hepatitis C virus (HCV) in veterans is unknown. Aim: To determine the treatment prescription rates and predictors of treatment prescription for HCV in a large national population. Methods: The Department of Veterans Affairs National Patient Care Database (NPCD) was used to identify all HCV-infected people between the fiscal years 1999 and 2003 using the International classification of diseases, 9th revision codes. Demographic information, medical and psychiatric comorbidities, and drug and alcohol use diagnoses were retrieved. Pharmacy data were retrieved from the Department of Veterans Affairs Pharmacy Benefits Management (PBM) database. Logistic regression analysis was used to determine the predictors of treatment for HCV in HCV. Results: 113 927 veterans in the Department of Veterans Affairs care with a diagnosis of HCV were identified. The treatment prescription rate for HCV was 11.8%. Patients not prescribed treatment were older, more likely to be from minority races, have more alcohol and drug misuse, and have medical and psychiatric comorbid conditions. In a multivariate logistic regression model, the following factors were predictive of nontreatment for HCV: increasing age (odds ratio (OR) 0.77 for each 5-year increase in age; 95% confidence interval (CI) 0.76 to 0.78); black race (OR 0.64; 95% CI 0.6 to 0. The following factors were associated with a higher likelihood of treatment prescription for HCV: liver cirrhosis (OR 1.6; 95% CI 1.5 to 1.7); and diabetes (OR 1.07; 95% CI 1.02 to 1.12). Conclusions: A small number of HCV-infected veterans were prescribed treatment for HCV. Non-treatment is associated with increasing age, non-white race, drug and alcohol abuse, and dependence and comorbid illnesses. Reasons for non-treatment need further study.

show abstract

“…25 HCV infection was defined as a positive HCV antibody test or $1 inpatient and/or $2 outpatient codes for this diagnosis. 26 Alcohol abuse or dependence, cocaine abuse or dependence, and atrial fibrillation (427.31) were defined using ICD-9 codes. 27,28 We also collected data on baseline CD4…”

Section: Patients the Veterans Aging Cohort Study-virtualmentioning

confidence: 99%

HIV status and the risk of ischemic stroke among men

et al. 2015

View full text Add to dashboard Cite

Objective: Given conflicting data regarding the association of HIV infection and ischemic stroke risk, we sought to determine whether HIV infection conferred an increased ischemic stroke risk among male veterans. Methods:The Veterans Aging Cohort Study-Virtual Cohort consists of HIV-infected and uninfected veterans in care matched (1:2) for age, sex, race/ethnicity, and clinical site. We analyzed data on 76,835 male participants in the Veterans Aging Cohort Study-Virtual Cohort who were free of baseline cardiovascular disease. We assessed demographics, ischemic stroke risk factors, comorbid diseases, substance use, HIV biomarkers, and incidence of ischemic stroke from October

show abstract

Relative prevalence of comorbidities and treatment contraindications in HIV-mono-infected and HIV/HCV-co-infected veterans

Abstract: HIV/HCV-co-infected veterans had a higher prevalence of comorbid conditions that may complicate and limit treatment options for HIV and for HCV co-infection. Strategies to improve treatment options for co-infected patients with comorbidities must be developed.

Cited by 106 publications

References 25 publications

Rates of HCV Treatment Eligibility Among HCV-Monoinfected and HCV/HIV-Coinfected Patients in Tertiary Care Referral Centers

Rates of HCV Treatment Eligibility Among HCV-Monoinfected and HCV/HIV-Coinfected Patients in Tertiary Care Referral Centers

Rate and predictors of treatment prescription for hepatitis C

HIV status and the risk of ischemic stroke among men

Contact Info

Product

Resources

About