Relative Radiosensitivities of the Small and Large Intestine

Becciolini, Aldo

doi:10.1016/b978-0-12-035412-2.50006-0

Cited by 30 publications

(15 citation statements)

References 171 publications

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“…Ileum is more radioresistant than jejunum (Becciolini 1987). This corresponds with our results showing lower apoptotic activity in the cryptal compartment, which possibly helped to preserve the average length of remaining crypts and height of villi at the control level 2 days after irradiation.…”

Section: Ileummentioning

confidence: 98%

Attenuation of radiation-induced gastrointestinal damage by epidermal growth factor and bone marrow transplantation in mice

Pejchal

Šinkorová

Tichý

et al. 2015

International Journal of Radiation Biology

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Section: Ileummentioning

confidence: 98%

Attenuation of radiation-induced gastrointestinal damage by epidermal growth factor and bone marrow transplantation in mice

Pejchal

Šinkorová

Tichý

et al. 2015

International Journal of Radiation Biology

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“…In the present study, the decrease of VIP receptor number observed after irradiation is unlikely to be due to an internalization, because results were obtained on whole membranes of the colonic mucosa. However, a degradation of the internalized VIP receptor by lysozymes could be postulated as a maximal increased lysozomal activity has been reported from 40-72 h after irradiation in the rat intestine (4).…”

Section: Discussionmentioning

confidence: 99%

“…The hyporesponsiveness to VIP is transitory, because I sc responses returned to normal values at 7 days after exposure. Temporal evolution of radiation effects may be explained by the crypt cell turnover time (4). The cell population originating from stem cells located at the base of the crypt produces by division new proliferative and differentiating cells.…”

Section: Discussionmentioning

confidence: 99%

Alterations of the VIP-stimulated cAMP pathway in rat distal colon after abdominal irradiation

Morel

Dublineau

Lebrun

et al. 2002

American Journal of Physiology-Gastrointestinal and Liver Physi

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Morel, E., I. Dublineau, F. Lebrun, and N. M. Griffiths. Alterations of the VIP-stimulated cAMP pathway in rat distal colon after abdominal irradiation. Am J Physiol Gastrointest Liver Physiol 282: G835-G843, 2002. First published January 9, 2002 10.1152/ajpgi.00457.2001.-Ionizing radiation induces hyporesponsiveness of rat colonic mucosa to vasoactive intestinal peptide (VIP). Possible mechanisms responsible for this hyporesponsiveness of the cAMP communication pathway in rat colon were investigated. VIP-and forskolin-stimulated short-circuit current (I sc) responses were studied after a 10-Gy abdominal irradiation in Ussing chambers as well as in single, isolated crypts. Adenylyl cyclase (AC) activity and VIP receptor characteristics were determined in mucosal membrane preparations. In addition, alterations in crypt morphology were studied. Impaired secretory responses to VIP and forskolin were observed 4 days after irradiation (decrease of 80%). cAMP analog-stimulated Isc responses were unchanged. In isolated crypts, VIP-and forskolin-stimulated cAMP accumulation was markedly reduced by 80 and 50%, respectively. VIP-stimulated AC activity and VIP receptor number were decreased in membrane preparations. No major change of cellularity was associated with these functional alterations. In conclusion, the decreased secretory responses to VIP of rat colon are associated with reduced cAMP accumulation, decreased AC activity, and diminution of VIP receptor numbers without a marked decrease of crypt cell number.

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“…Becciolini a montré, chez des patients ayant reçu une radiothérapie, une diminution de 25 à 30 % de l'absorption des lipides, de la vitamine B 12 et des hydrates de carbone. L'absorption des acides aminés est moins atténuée (Becciolini, 1987). En effet, chez le rat, Cheeseman et ul.…”

Section: Absorption Et Sécrétionunclassified