Relative reactivity of substituted acetophenones in enantioselective biocatalytic reduction catalyzed by plant cells of Daucus carota and Petroselinum crispum

Enhanced Electroreduction of Acetophenone Using Lipase Stabilization: Improved Conversion to 1‐Phenylethanol

“…In general, it is possible to attribute the significantly lower percentages of the products of interest in the final reaction medium to the action of different chemical effects and to the limited solubility of substituted aromatic ketones in the aqueous medium, which makes the reaction slow and, sometimes, ineffective [72,73] . Mainly the brominated derivative suffered with the solubility, being visually insoluble in the medium, explaining the low conversion observed.…”

“…In general, it is possible to attribute the significantly lower percentages of the products of interest in the final reaction medium to the action of different chemical effects and to the limited solubility of substituted aromatic ketones in the aqueous medium, which makes the reaction slow and, sometimes, ineffective. [72,73] Mainly the brominated derivative suffered with the solubility, being visually insoluble in the medium, explaining the low conversion observed. Finally, it is undoubtedly important to highlight that the electronic charge distribution in the molecules of the substituted substrates tested may be influencing their orientation in the oxyanion pocket of the selected enzyme, [73] as well as their interaction with other parts of the three-dimensional structure of the lipase from Thermomyces lanuginosus, especially with the lid, affecting the performance of the biocatalyst in electroreduction.…”