Relative risk of renal disease among people living with HIV: a systematic review and meta-analysis

Islam, Fakhrul; Wu, Jianyun; Jansson, James; Wilson, David

doi:10.1186/1471-2458-12-234

Cited by 98 publications

(74 citation statements)

References 32 publications

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“…factors for kidney disease that are more frequent in women than in men [3][4][5][6] . Pregnancy places an additional burden on the kidney health of women and complications of pregnancy are a frequent cause of kidney disease 7 .…”

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confidence: 99%

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Kidneys and women's health: key challenges and considerations

et al. 2018

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The theme of World Kidney Day 2018 is 'kidneys and women's health: include, value, empower'.To mark this event, Nature Reviews Nephrology asked four leading researchers to discuss key considerations related to women's kidney health, including specific risk factors, as well as the main challenges and barriers to care for women with kidney disease and how these might be overcome. They also discuss policies and systems that could be implemented to improve the kidney health of women and their offspring and the areas of research that are needed to improve the outcomes of kidney disease in women. Q. Why is the topic of "kidneys and women's health" particularly important?Gloria E. Ashuntantang. Acute kidney injury (AKI) and chronic kidney disease (CKD) are growing public health problems that are associated with adverse clinical and psychosocial outcomes 1 . Globally, CKD is more prevalent in women (~272 million) than in men (~226 million) 2 , and sex differences exist in all aspects of kidney health, from epidemiology, pathogenesis and care to outcomes. In addition to risk factors in common with men, such as diabetes mellitus and hypertension, the specific biology of women exposes them to unique risk factors for AKI and CKD.Systemic lupus erythematosus (SLE), HIV infection and urinary tract infections (UTIs) are known risk

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confidence: 99%

“…UTIs are more frequent in women than in men due in part to the shorter urethra and its proximity to the anus 6 . HIV infection 5 , and complications of pregnancy, including pre-eclampsia, are risk factors for AKI and CKD. Pregnancy-related AKI accounts for 15-25% of AKI in low-income countries and is responsible for around 8% of maternal and fetal deaths 7 .…”

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confidence: 99%

Kidneys and women's health: key challenges and considerations

et al. 2018

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“…Therefore, renal function assessment before and after initiation is critical; and in patients with renal dysfunction, tenofovir is better avoided [9]. This safety concern was observed to a lesser extent with other ARTs [6][7][8], yet more studied and confirmed with tenofovir [13][14][15]. In clinical practice, another problem arises regarding assessing the long term renal safety of tenofovir due to higher discontinuation rates with decreasing eGFR [7].…”

Section: Backgroundnephropathy In Plhivmentioning

confidence: 99%

“…Five HIV-specific CKD risk factors were identified in the literature and incorporated in the model basing on the results of comparative studies: -PLHIV versus HIV-uninfected people [14]; -Late-stage HIV infection versus non-AIDS PLHIV [14]; -ART versus treatment-naïve PLHIV [14]; -Nucleoside reverse transcriptase inhibitors (NRTIs) pair: -specific for each drugs [6]; -including vs not including tenofovir [13]. -Third drug prescription [6].…”

Section: Hiv Factor Risksmentioning

confidence: 99%

Simulating the development and progression of Chronic Kidney Disease and osteoporosis in people living with HIV

Адами¹,

Maggi²,

Montinaro³

et al. 2016

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The "chronicization" of HIV infection brings about a growing necessity to attentively evaluate current and potential complications when prescribing the individual therapeutic regimen. Starting from this need, we developed two HIV-comorbidity simulators that, basing on the evidence available in medical literature and starting from the current clinical and demographic features of the individual patient, project and compare the risks of developing and worsening of nephropathy and osteopathy associated with possible ARV regimens. These simulators are embedded in a desktop, user-friendly software thought to be used by the treating physician during prescription discussion with his/her patients, in order to highlight expected clinical outcomes and healthcare resource consumption that may differ according to the therapeutic strategy selected. In this article we present the sources and methods used in developing the mathematical models, alongside a set of examples and the results of cohort-level validation runs.

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“…7,8 Renal chronic disease is three times more prevalent than in the general population. 9,10 However, the real frequency of renal abnormalities has been reported to range from 1% to 30%, depending on the characteristics of the study population (e.g., race, age, and co-morbidities) [11][12][13] and the definition of the abnormality evaluated (e.g., chronic kidney disease or signs of renal damage, that is, presence of proteinuria, albuminuria, or other signs of altered urine markers) in the absence of altered estimated glomerular filtration rate (eGFR).…”

Section: Introductionmentioning

confidence: 99%

High Prevalence of Signs of Renal Damage Despite Normal Renal Function in a Cohort of HIV-Infected Patients: Evaluation of Associated Factors

Bonjoch

Juega

Puig

et al. 2014

AIDS Patient Care and STDs

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Renal disorders are an emerging problem in HIV-infected patients. We performed a cross-sectional study of the first 1000 HIV-infected patients attended at our HIV unit who agreed to participate. We determined the frequency of renal alterations and its related risk factors. Summary statistics and logistic regression were applied. The study sample comprised 970 patients with complete data. Most were white (94%) and men (76%). Median (IQR) age was 48 (42-53) years. Hypertension was diagnosed in 19%, dyslipidemia in 27%, and diabetes mellitus in 3%. According to the Chronic Kidney Disease Epidemiology Collaboration (CKD EPI) equation, 29 patients (3%) had an eGFR < 60 ml/min/1.73 m 2 ; 18 of them (62%) presented altered albumin/creatinine and protein/creatinine (UPC or UAC) ratios. Of the patients with eGFR > 60 mL/min, it was present in 293 (30%), 38 of whom (7.1%) had UPC > 300 mg/g. Increased risk of renal abnormalities was correlated with hypertension (OR, 1.821 [95%CI, 1.292;2.564]; p = 0.001), age (OR, 1.015 [95%CI, 1.001;1.030], per one year; p = 0.040), and use of tenofovir disoproxil fumarate (TDF) plus protease inhibitor (PI), (OR, 1.401 [95%CI, 1.078;1.821]; p = 0.012). Current CD4 cell count was a protective factor (OR, 0.9995 [95%CI, 0.9991;0.9999], per one cell; p = 0.035). A considerable proportion of patients presented altered UPC or UAC ratios, despite having an eGFR > 60 mL/min. CD4 cell count was a protective factor; age, hypertension, and use of TDF plus PIs were risk factors for renal abnormalities. Based on our results, screen of renal abnormalities should be considered in all HIV-infected patients to detect these alterations early.

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Relative risk of renal disease among people living with HIV: a systematic review and meta-analysis

Cited by 98 publications

References 32 publications

Kidneys and women's health: key challenges and considerations

Kidneys and women's health: key challenges and considerations

Simulating the development and progression of Chronic Kidney Disease and osteoporosis in people living with HIV

High Prevalence of Signs of Renal Damage Despite Normal Renal Function in a Cohort of HIV-Infected Patients: Evaluation of Associated Factors

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