Relative roles of oestradiol and of the uterus in the maintenance of the corpus luteum in the pseudopregnant brown hare (Lepus europaeus)

Caillol, Monique; Martinet, Lise; Lacroix, Marie-Christine

doi:10.1530/jrf.0.0870603

Cited by 10 publications

(7 citation statements)

References 29 publications

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“…Adams et al (1981) demonstrated that the phytoestrogenic syndrome in sheep involves extension of the life of the corpus luteum in a proportion of ewes and therefore prolongation of the influence of progesterone and resultant pathologic changes. In the rabbit, exogenous estrogens do not prolong the life of the corpus luteum (Miller and Keynes, 1976), whereas they do in hares (Caillol et al, 1989). Hence, the presence of lesions in hares exposed to phytoestrogens but not in sympatric rabbits is consistent with our observations.…”

Section: Discussionsupporting

confidence: 90%

“…Cystic endometrial hyperplasia is the major indication of phytoestrogenism in sheep (Bennetts et al, 1946). Hares are particularly sensitive to the luteotrophic effect of exogenous estrogen, which can double the length of pseudopregnancy in that species (Caillol et al, 1986(Caillol et al, , 1989. The formation of secretory cells in the oviducts can be induced by exogenous estrogen (Fredricsson, 1959cited by Odor et al, 1989.…”

Section: Discussionmentioning

confidence: 99%

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Female Reproductive Tract Abnormalities in European Hares (Lepus Europaeus) in Australia

Stott

Wight

2004

Journal of Wildlife Diseases

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Populations of European hare (Lepus europaeus) are in decline in Europe, and populations in Australia remain at low densities. Populations are sensitive to size of the breeding stock, which is influenced by fertility in the females. From 1996 to 1999, a total of 272 adult female hares from three Australian populations were dissected and their reproductive systems examined for abnormalities. Cystic endometrial hyperplasia was relatively common and often accompanied by hydrosalpinx. Extrauterine fetuses, neoplasms, pseudopregnancies, and resorptions also were found. However, although pseudopregnancies and resorptions were found in young adults (Ͻ12 mo) as well as older hares, conditions possibly causing infertility were almost always in older hares with prevalences up to 46.2%. Only hares with access to known sources of estrogens exhibited pathologic conditions, but sympatric European rabbits (Oryctolagus cuniculus) did not, which is consistent with known difference in responses between the corpora lutea of the two species to exogenous estrogen. Infertility at such a high prevalence could compound and extend the impact of years of low juvenile survival on recruitment.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Female Reproductive Tract Abnormalities in European Hares (Lepus Europaeus) in Australia

Stott

Wight

2004

Journal of Wildlife Diseases

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“…The uterine enlargement (Calliol et al, 1989a), increased progesterone (Calliol and Martinet, 1976;Calliol etal., 1991) and estradiol (Caillol et al, 1989a(Caillol et al, , 1991Semizorova et al, 1990) levels in the blood of females have been reported. In males, growth of testicles and increased blood testosterone levels (Calliol et al, 1989b) during the reproductive cycle have been described.…”

Section: Introductionmentioning

confidence: 94%

Seasonal variations in the morphometric analysis of the testis, testosterone production, and occurrence of pathological spermatozoa in the brown hare (<i>Lepus europaeus</i>)

Massányi¹,

Slamečka²,

Lukáč³

et al. 2000

J. Anim. Feed Sci.

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Seasonal variations in the morphometric analysis of the testis, variations in testosterone production, and occurrence of pathological spermatozoa in the brown hare {Lepus europaeus) were studied.In evaluating the relative volume of germinal epithelium, interstitium and lumen in hare testis we found the highest relative volume of germinal epithelium in the winter (84.14%). The lowest level was found in the summer, but the highest relative volumes of interstitium (12.47%) and lumen (18.11 %) were in the summer. The germinal epithelium achieved a maximum height in the winter (35.47 um), when the diameter of the seminiferous tubules was also at a maximum (320.75 pm). These data are supported by analysis of testosterone production, which shows that the highest concentration of testosterone in blood was found in the winter (5.72 ng/ml), the lowest in the summer (0.87 ng/ml). This difference was significant (P<0.01).Analysis of pathological spermatozoa showed that their occurrence ranged from 11.50 to 24.17%, with the highest value in the spring. As the spermatozoa were collected from the epididymis, the most frequently found pathological form was spermatozoa with retention of the cytoplasmic drop.

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“…Enlargement of the uterus (Calliol et al, 1989a) and increases in the levels of progesterone (Calliol and Martinet, 1976;Calliol etal., 1991) and oestradiol (Caillol et al, 1989a(Caillol et al, ,b, 1991Semizorova et al, 1990) have been documented. These authors studied mostly cage-bred brown hares, not animals from the wild.…”

Section: Introductionmentioning

confidence: 96%

Seasonal variations in the morphometric analysis of the ovary and uterus and in progesterone and 17β-oestradiol production in the brown hare (<i>Lepus europaeus</i>)

Massányi¹,

Slamečka²,

Lukáč³

et al. 2000

J. Anim. Feed Sci.

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Seasonal variations in the morphometry of the ovary and uterus, and in progesterone and 17(3-oestradiol production in 37 brown hares (Lepus europaeus), 10 in spring, 7 in summer, 14 in autumn, and 6 in winter, are reported.Evaluation of the relative volume of primary and growing follicles, and stroma in the hare ovary revealed a stable level of primary follicles during the year. The highest relative volume of growing follicles was found in the autumn, with a similar value in winter. As the relative volume of growing follicles increased, the amount of stroma decreased. The lowest relative volume of stroma was found in the autumn (90.1 %) and the highest in the spring (97.3%). No significant differences were found in the relative volumes of follicles and stroma in the ovary. The diameter of primary follicles ranged from 30.8 to 35.9 u,m during the year, with no significant seasonal difference. The diameter of growing follicles ranged from 139 to 222 |im.The highest relative volume of endometrium in the uterus occurred in the autumn and summer.This difference was significant in comparison with spring (P<0.05). The height of the endometrium was highest in the summer and lowest in the winter. Detailed analysis of the endometrium showed that the highest relative volume of the surface epithelium was in the spring (6.5%), the highest relative volume of glandular epithelium in the winter (22.4%), and the highest relative volume of stroma in the autumn (85.8%). The highest surface epithelium was found in the spring. The average diameter of uterine glands was highest in the spring (63.5%), but the differences between seasons were not significant. VARIATIONS IN THE OVARY AND UTERUS IN HAREAnalysis of progesterone and 17P~oestradol in hare blood showed that the highest levels of progesterone occurred in the spring (22.91 ng/ml). Significant differences were found in the progesterone concentration between spring and autumn (P<0.001). For 17p-oestradiol, the highest concentrations occurred in the winter and the lowest in the summer.The results of this study clearly demonstrate that the highest follicular growth in the brown hare occurs in the autumn, which corresponds with the highest relative volume of uterine glandular epithelium in winter as well as with the highest diameter of uterine glands in the spring. We suggest that in our conditions, the reproductive activity in the female brown hare starts in the autumn.

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Relative roles of oestradiol and of the uterus in the maintenance of the corpus luteum in the pseudopregnant brown hare (Lepus europaeus)

Cited by 10 publications

References 29 publications

Female Reproductive Tract Abnormalities in European Hares (Lepus Europaeus) in Australia

Female Reproductive Tract Abnormalities in European Hares (Lepus Europaeus) in Australia

Seasonal variations in the morphometric analysis of the testis, testosterone production, and occurrence of pathological spermatozoa in the brown hare (<i>Lepus europaeus</i>)

Seasonal variations in the morphometric analysis of the ovary and uterus and in progesterone and 17β-oestradiol production in the brown hare (<i>Lepus europaeus</i>)

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