1987
DOI: 10.1097/00004583-198705000-00021
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Relative Safety of Single Versus Divided Dose Imipramine in Adolescent Major Depression

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Cited by 24 publications
(3 citation statements)
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“…Adults show more than a 30-fold difference in plasma levels at a given dose (Sjoqvist and Bertilsson, 1984), and similarly wide variations in plasma level are seen in children and adolescents (Preskorn etal. 1983;Ryan et al 1987). DOSAGE AND REGIMEN Enuresis.…”
Section: Pharmacokinetics In Children and Adolescentsmentioning
confidence: 99%
See 1 more Smart Citation
“…Adults show more than a 30-fold difference in plasma levels at a given dose (Sjoqvist and Bertilsson, 1984), and similarly wide variations in plasma level are seen in children and adolescents (Preskorn etal. 1983;Ryan et al 1987). DOSAGE AND REGIMEN Enuresis.…”
Section: Pharmacokinetics In Children and Adolescentsmentioning
confidence: 99%
“…Large increases in conduction slowing (PR > 0.21, QRS > 0.12) can lead to potentially dangerous cardiac function. Although children generally do not have the cardiac disorders seen in older adult patients, the immature cardiac system is more susceptible to the cardiotoxic effects of tricyclic antidepressants (Ryan et al 1987). Induction ofpsychosis.…”
Section: Uncommon But Potentially Serious Adverse Effectsmentioning
confidence: 99%
“…However, more severe conduction slowing may result in serious cardiac dysfunctions, including heart block or arrhythmia (Ryan 1990). Since children may be at greater risk than adults for the cardiotoxic effects of TCAs (Ryan et al 1987), there is a general belief that the cardiotoxicity of TCAs may be the crucial adverse effect that is responsible for these three cases of sudden death.…”
Section: Speculations On Mechanismsmentioning
confidence: 99%