Relative trends in hospitalizations and mortality among infants by the number of vaccine doses and age, based on the Vaccine Adverse Event Reporting System (VAERS), 1990–2010

Goldman, Gary S.; Miller, Neil Z.

doi:10.1177/0960327112440111

Cited by 30 publications

(33 citation statements)

References 24 publications

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“…The reason for hospitalization and the age of the child at the time were not determined, but the latter finding appears consistent with a study of 38,801 reports to the VAERS of infants who were hospitalized or had died after receiving vaccinations. The study reported a linear relationship between the number of vaccine doses administered at one time and the rate of hospitalization and death; moreover, the younger the infant at the time of vaccination, the higher was the rate of hospitalization and death [55]. The hospitalization rate increased from 11% for 2 vaccine doses to 23.5% for 8 doses (r 2 = 0.91), while the case fatality rate increased significantly from 3.6% for those receiving from 1-4 doses to 5.4 % for those receiving from 5-8 doses.…”

Section: Discussionmentioning

confidence: 97%

Pilot comparative study on the health of vaccinated and unvaccinated 6- to 12- year old U.S. children

Mawson¹,

Ray²,

Bhuiyan³

et al. 2017

J Transl Sci

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Vaccinations have prevented millions of infectious illnesses, hospitalizations and deaths among U.S. children, yet the long-term health outcomes of the vaccination schedule remain uncertain. Studies have been recommended by the U.S. Institute of Medicine to address this question. This study aimed 1) to compare vaccinated and unvaccinated children on a broad range of health outcomes, and 2) to determine whether an association found between vaccination and neurodevelopmental disorders (NDD), if any, remained significant after adjustment for other measured factors. A cross-sectional study of mothers of children educated at home was carried out in collaboration with homeschool organizations in four U.S. states: Florida, Louisiana, Mississippi and Oregon. Mothers were asked to complete an anonymous online questionnaire on their 6-to 12-year-old biological children with respect to pregnancy-related factors, birth history, vaccinations, physician-diagnosed illnesses, medications used, and health services. NDD, a derived diagnostic measure, was defined as having one or more of the following three closely-related diagnoses: a learning disability, Attention Deficient Hyperactivity Disorder, and Autism Spectrum Disorder. A convenience sample of 666 children was obtained, of which 261 (39%) were unvaccinated. The vaccinated were less likely than the unvaccinated to have been diagnosed with chickenpox and pertussis, but more likely to have been diagnosed with pneumonia, otitis media, allergies and NDD. After adjustment, vaccination, male gender, and preterm birth remained significantly associated with NDD. However, in a final adjusted model with interaction, vaccination but not preterm birth remained associated with NDD, while the interaction of preterm birth and vaccination was associated with a 6.6-fold increased odds of NDD (95% CI: 2.8, 15.5). In conclusion, vaccinated homeschool children were found to have a higher rate of allergies and NDD than unvaccinated homeschool children. While vaccination remained significantly associated with NDD after controlling for other factors, preterm birth coupled with vaccination was associated with an apparent synergistic increase in the odds of NDD. Further research involving larger, independent samples and stronger research designs is needed to verify and understand these unexpected findings in order to optimize the impact of vaccines on children's health.

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Section: Discussionmentioning

confidence: 97%

Pilot comparative study on the health of vaccinated and unvaccinated 6- to 12- year old U.S. children

Mawson¹,

Ray²,

Bhuiyan³

et al. 2017

J Transl Sci

View full text Add to dashboard Cite

show abstract

“…Goldman and Miller [96] have previously examined the VAERS database, specifically looking at hospitalization rates and mortality statistics as a function of the number of vaccines simultaneously administered and of age. Linear regression analysis revealed several statistically significant trends, including a positive correlation between hospitalization rates and number of vaccine doses.…”

Section: Other Related Workmentioning

confidence: 99%

Empirical Data Confirm Autism Symptoms Related to Aluminum and Acetaminophen Exposure

Seneff

Davidson²,

Liu

2012

Entropy

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Autism is a condition characterized by impaired cognitive and social skills, associated with compromised immune function. The incidence is alarmingly on the rise, and environmental factors are increasingly suspected to play a role. This paper investigates word frequency patterns in the U.S. CDC Vaccine Adverse Events Reporting System (VAERS) database. Our results provide strong evidence supporting a link between autism and the aluminum in vaccines. A literature review showing toxicity of aluminum in human physiology offers further support. Mentions of autism in VAERS increased steadily at the end of the last century, during a period when mercury was being phased out, while aluminum adjuvant burden was being increased. Using standard log-likelihood ratio techniques, we identify several signs and symptoms that are significantly more prevalent in vaccine reports after 2000, including cellulitis, seizure, depression, fatigue, pain and death, which are also significantly associated with aluminum-containing vaccines. We propose that children with the autism diagnosis are especially vulnerable to toxic metals such as aluminum and mercury due to insufficient serum sulfate and glutathione. A strong correlation between autism and the MMR (Measles, Mumps, Rubella) vaccine is also observed, which may be partially explained via an increased sensitivity to acetaminophen administered to control fever.

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“…Brachial neuritis afflicts up to 10 of every million tetanus vaccinees [7]. The Centers for Disease Control and Prevention (CDC) in the U.S. recommended 26 vaccine doses for infants in 2007 with clinical implications suggesting deleterious impacts on infants' health due to uncharacterized interference among unrelated vaccines after consecutive cycles of intensive immunization [8]. All measlescontaining vaccines are associated with several types of adverse events, including seizure, fever, and immune thrombocytopenia purpura [9].…”

Section: Anti-vaccine Movements Fueled By Vaccines' Incertitudementioning

confidence: 99%

Noninvasive vaccination as a casus belli to redeem vaccine value in the face of anti-vaccine movements

Tang¹

2017

Integr Mol Med

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Formidable anti-vaccine movements have been growing as a menace to disrupt beneficial vaccine programs. Although the vaccination-associated adverse effects commonly perceived by vaccine resisters usually represent over-reactions to rare manifestations, converging evidence shows that vaccination-associated health threats could be pervasive when systemic inflammation is considered as a side effect that oozes over time. An anti-vaccine movement thus may not be so unfounded even though the myriad cascades triggered by systemic inflammation have not been brought to a clear focus during any anti-vaccine campaign. Since both pro-and antivaccine groups are acting on the same primal impulse -"keep people healthy," reconciliation between the two warring factions should be achievable on a palatable trend that fosters the development of noninvasive vaccines which tend to induce local and transient inflammation along the interface with diminished potential to percolate through internal organs. Anti-vaccine movements fueled by vaccines' incertitudeVaccination is widely heralded as a medical paradigm credited with mitigation of many vaccination-preventable diseases through massimmunization programs. However, its success has also precipitated an active opposition. The genesis of the anti-vaccine movement surge could be traced back to the anti-vaccine sentiment catalyzed by the Britain's Compulsory Vaccination Act of 1853, which mandated the vaccination of all infants [1]. The controversial pertussis and hepatitis B virus (HBV) vaccines in conjunction with the apocryphal link between vaccination and autism not only re-catalyzed a groundswell of antivaccine activism but catapulted it into a phase of erudite opposition [2].Anti-vaccine groups are formed mostly by affluent "knowledge seekers" who claim the right to make "informed choices" about vaccination [2][3][4]. Today's vaccines largely represent a double-edged sword to vaccine resisters even though they are agnostic about what causes vaccines' side effects. Regardless of their creeds, the incipient anti-vaccine movements have been implicated in low vaccine coverages in conjunction with hazardous outbreaks of preventable diseases [5].The grand success of vaccination programs is undeniable, and no anti-vaccine groups in the modern era have advocated a divorce by forbidding vaccines altogether in the medical arsenal. The schism between vaccine supporters and resisters can be attributed to the scope of restricted use of vaccines. Vaccine supporters' zeitgeist is based on the belief that vaccines' risks are minuscule with their core health benefits in vanquishing diseases far eclipse their risks, whereas vaccine resisters fear the brunt of vaccination due to vaccines' incertitude and their arcane mechanisms of action. Overall, the bifurcated stances are not as mutually exclusive from an ethical perspective.Vaccine supporters often impugn vaccine resisters for avoiding vaccination against communicable diseases on the premise that individuals opting out of immunization may j...

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Relative trends in hospitalizations and mortality among infants by the number of vaccine doses and age, based on the Vaccine Adverse Event Reporting System (VAERS), 1990–2010

Cited by 30 publications

References 24 publications

Pilot comparative study on the health of vaccinated and unvaccinated 6- to 12- year old U.S. children

Pilot comparative study on the health of vaccinated and unvaccinated 6- to 12- year old U.S. children

Empirical Data Confirm Autism Symptoms Related to Aluminum and Acetaminophen Exposure

Noninvasive vaccination as a casus belli to redeem vaccine value in the face of anti-vaccine movements

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