Objective: To evaluate the relationships among performance validity, symptom validity, symptom self-report, and objective cognitive testing. Method: Combat Veterans (N = 338) completed a neurocognitive assessment battery and several self-report symptom measures assessing depression, posttraumatic stress disorder (PTSD) symptoms, sleep quality, pain interference, and neurobehavioral complaints. All participants also completed two performance validity tests (PVTs) and one stand-alone symptom validity test (SVT) along with two embedded SVTs. Results: Results of an exploratory factor analysis revealed a three-factor solution: performance validity, cognitive performance, and symptom report (SVTs loaded on the third factor). Results of t tests demonstrated that participants who failed PVTs displayed significantly more severe symptoms and significantly worse performance on most measures of neurocognitive functioning compared to those who passed. Participants who failed a standalone SVT also reported significantly more severe symptomatology on all symptom report measures, but the pattern of cognitive performance differed based on the selected SVT cutoff. Multiple linear regressions revealed Key Points Question: Are performance validity tests (PVTs) and symptom validity tests (SVT) measuring different constructs, and are they differentially related to cognition and clinical symptoms? Findings: Symptom validity and performance validity are distinct but related constructs, and both are associated with cognitive performance and with symptom self-report. Importance: A comprehensive neuropsychological assessment battery should include both SVT and PVTs because they provide unique information about an examinee's performance. Next Steps: Further evaluation of specific symptom validity measures is necessary to assess distinct differences between symptom validity and symptom selfreport, as well as to determine whether higher cutoffs would be more appropriate for various populations, such as combat-exposed Veterans.