Relative weight-related costs of healthcare use by children—Results from the two German birth cohorts, GINI-plus and LISA-plus

Breitfelder, Ariane; Wenig, Christina M.; Wolfenstetter, Silke B.; Rzehak, Peter; Menn, Petra; John, Jürgen; Leidl, Reiner; Bauer, Carl Peter; Koletzko, Sibylle; Röder, Stefan; Herbarth, Olf; Berg, Andrea von; Berdel, Dietrich; Krämer, Ursula; Schaaf, Beate; Wichmann, H‐Erich; Heinrich, Joachim

doi:10.1016/j.ehb.2011.02.001

Cited by 40 publications

(40 citation statements)

References 49 publications

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“…Die Ergebnisse deuten darauf hin, dass über-gewichtige und adipöse Kinder bereits im Alter von circa zehn Jahren mehr Gesundheitsleistungen (Arzt-und Therapeutenbesuche, Krankenhaus, stationäre Rehabilitation) als normalgewichtige Kinder in Anspruch nehmen. Die indirekten Kosten waren für adipöse Kinder ebenfalls erhöht [46]. In einem nächsten Schritt wird die longitudinale Struktur der GINIplus-und LISAplus-Geburtskohorten genutzt, um zu untersuchen, ob neben dem aktuellen Gewicht auch die frühere Entwicklung des BMI einen Einfluss auf die Krankheitskosten hat [47].…”

Section: Inanspruchnahme Von Gesundheitsleistungen Und Krankheitskostenunclassified

Die zwei deutschen Geburtskohorten GINIplus und LISAplus

Heinrich

Brüske

Schnappinger

et al. 2012

Bundesgesundheitsbl.

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Numerous chronic diseases in childhood and adulthood have their origins in perinatal life and are potentially influenced by trans-generational epigenetic processes. Therefore, prospective birth cohorts can substantially contribute to our knowledge about the etiology of diseases including modifiable risk factors. The two population-based German birth cohorts GINIplus and LISAplus aim to describe the natural course of chronic diseases and intermediate phenotypes in childhood and its determinants, and to identify potential genetic effect modifications. In the mid-1990s, 5,991 (GINIplus) and 3,097 (LISAplus) healthy, term newborns were recruited for long-term follow-up in four regions of Germany. The follow-up rate for the first 10 years was about 55%. We analyzed the growth and development of overweight, infections and allergic diseases, mental and oral health, metabolic and inflammatory parameters and the role of potential risk factors including genetics. The results of these two birth cohorts substantially contribute to the current knowledge about the natural course of these health parameters. These data were included in many international projects and consortia for purposes of international comparisons of prevalence and consistency of findings, and to increase the power of the analyses.

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Section: Inanspruchnahme Von Gesundheitsleistungen Und Krankheitskostenunclassified

Die zwei deutschen Geburtskohorten GINIplus und LISAplus

Heinrich

Brüske

Schnappinger

et al. 2012

Bundesgesundheitsbl.

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“…For the 10-year (120 months) follow-up, anthropometric measurements were taken by physical examination at the study centers. Thus, the maximum number of observations per child was 10. Further details on the LISA study can be found in Breitfelder et al [22] and Rzehak et al [23].…”

Section: Data Descriptionmentioning

confidence: 99%

Boosting Structured Additive Quantile Regression for Longitudinal Childhood Obesity Data

Fenske

Fahrmeir

Hothorn

et al. 2013

The International Journal of Biostatistics

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Childhood obesity and the investigation of its risk factors has become an important public health issue. Our work is based on and motivated by a German longitudinal study including 2,226 children with up to ten measurements on their body mass index (BMI) and risk factors from birth to the age of 10 years. We introduce boosting of structured additive quantile regression as a novel distribution-free approach for longitudinal quantile regression. The quantile-specific predictors of our model include conventional linear population effects, smooth nonlinear functional effects, varying-coefficient terms, and individual-specific effects, such as intercepts and slopes. Estimation is based on boosting, a computer intensive inference method for highly complex models. We propose a component-wise functional gradient descent boosting algorithm that allows for penalized estimation of the large variety of different effects, particularly leading to individual-specific effects shrunken toward zero. This concept allows us to flexibly estimate the nonlinear age curves of upper quantiles of the BMI distribution, both on population and on individual-specific level, adjusted for further risk factors and to detect age-varying effects of categorical risk factors. Our model approach can be regarded as the quantile regression analog of Gaussian additive mixed models (or structured additive mean regression models), and we compare both model classes with respect to our obesity data.

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“…Childhood obesity often persists into adulthood and can substantially decrease quality of life [3], increase the risk of metabolic syndrome and adult morbidities [4,5], and be a heavy financial burden on the public health system [6]. …”

Section: Introductionmentioning

confidence: 99%

Food Intake and Overweight in School-Aged Children in Germany: Results of the GINIplus and LISAplus Studies

et al. 2014

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Objective: To investigate the cross-sectional association between food intake and overweight in children. Methods: Height and weight were measured in 2,565 school-aged children. Intakes of 11 food groups were categorized (low, medium and high) using specific tertile cutoffs. Multivariate energy partition models were applied. Adjustment included energy intake from other food groups, city, family income, parental education and ‘screen' time. Possible underreporters were identified and used in sensitivity analyses. Results: Compared to low intake, high intakes of meat, fish, beverages and bakery products were associated with greater BMI z-scores [β (95% CI) = 0.32 (0.21, 0.42), 0.13 (0.03, 0.24), 0.23 (0.11, 0.35) and 0.10 (-0.01, 0.20)] and increased risk of being overweight [odds ratio (OR) (95% CI) = 2.08 (1.58, 2.73), 1.39 (1.08, 1.80), 1.36 (1.01, 1.84) and 1.62 (1.24, 2.11)]. Conversely, medium and high intakes of confectionery were associated with smaller BMI z-scores [β = -0.18 (-0.28, -0.07) and -0.22 (-0.33, -0.12)] and decreased risk of being overweight [OR = 0.64 (0.50, 0.83) and 0.53 (0.40, 0.68)]. These associations were robust to sensitivity analyses. Conclusions: Intakes of meat, fish, beverages and bakery products correlate with body weight status.

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Relative weight-related costs of healthcare use by children—Results from the two German birth cohorts, GINI-plus and LISA-plus

Cited by 40 publications

References 49 publications

Die zwei deutschen Geburtskohorten GINIplus und LISAplus

Die zwei deutschen Geburtskohorten GINIplus und LISAplus

Boosting Structured Additive Quantile Regression for Longitudinal Childhood Obesity Data

Food Intake and Overweight in School-Aged Children in Germany: Results of the GINIplus and LISAplus Studies

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