The differential cross section and the transverse-transverse interference structure function for the reaction 2 H͑e, e 0 p͒n have been determined at an np invariant mass of 2.16 GeV. The data, covering a 40 ± range in the proton emission angle, indicate that D excitation and subsequent ND interaction is the dominant reaction mechanism. Calculations performed within an ND coupled-channel approach reproduce the cross section data, but underestimate the f TT results by 30 to 40 percent.[S0031-9007(97)03090-1] PACS numbers: 25.10. + s, 13.60. Rj, 13.75.Cs, 25.30.Rw Deuteron electrodisintegration in the D-resonance region offers an excellent probe to investigate the dynamics of the D isobar in a nuclear system. While at low energy transfer the deuteron response is reproduced by microscopic calculations based on realistic NN potentials, at higher energy transfer the first nucleon resonance, the D or P 33 baryon, plays an important role. This has been illustrated in several theoretical studies [1,2].Many electron scattering experiments have been devoted to deuteron disintegration in quasifree kinematics. Of these, the exclusive ͑e, e 0 p͒ measurements have provided the most detailed information on the deuteron structure. In the unpolarized ͑e, e 0 p͒ reaction, the information on the dynamics of the two-nucleon system is contained in four structure functions: the longitudinal f L , the transverse f T , and the interference terms f LT and f TT . Measurements of the differential cross section and in some cases of the individual structure functions f L , f T , and f LT [3][4][5][6][7][8][9][10][11][12][13][14][15] have provided stringent tests of the existing theoretical models [16][17][18][19]. In particular, the f L and f T data were reproduced by the existing calculations [7,10], while the f LT data pointed to the need for a relativistic form of the current operator [8,[11][12][13][14]. The measurement of f TT is more difficult, since it requires the detection of protons outside of the electron scattering plane. Hitherto, only one measurement [6] has been reported, at very low transferred energy and momentum ͑v, jqj͒ ͑18 MeV, 160 MeV͞c͒; the f TT results were not significantly different from zero.Although the effects of D isobar currents (IC) are small in quasifree kinematics, they are expected to become important at higher excitation energies. In the Dresonance region, which corresponds to an np invariant mass W np of about 2.17 GeV, one has to treat the D isobar and the nucleon degrees of freedom in a coupledchannel (CC) approach, as was shown for NN scattering in Ref. [20], and for electromagnetic deuteron break-up first in Ref.[21] and more recently in improved calculations in Refs. [22,23]. These models predict that the 2 H͑e, e 0 p͒n reaction in the D-resonance region is almost purely transverse in character and therefore the structure functions f T and f TT essentially generate the entire cross section. These structure functions in turn are predicted to have the characteristic features of a dominant M1 multipo...