In this work, we study how the combination of rotation and a topological defect can influence the energy spectrum of a two dimensional electron gas in a strong perpendicular magnetic field. A deviation from the linear behavior of the energy as a function of magnetic field, caused by a tripartite term of the Hamiltonian, involving magnetic field, the topological charge of the defect and the rotation frequency, leads to novel features which include a range of magnetic field without corresponding Landau levels and changes in the Hall quantization steps.