Relaxant effect of aqueous extract of Cistus ladaniferus on rodent intestinal contractions

Aziz, Mohammed; Tab, Naoual; Karim, Ahmed; Mekhfi, Hassane; Bnouham, Mohamed; Ziyyat, Abderrahim; Melhaoui, Ahmed; Legssyer, Abdelkhaleq

doi:10.1016/j.fitote.2006.05.015

Cited by 21 publications

(16 citation statements)

References 10 publications

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“…Cistus species have widespread utilization in Turkish folk medicine to cure some ailments like rheumatism, stomachache, hemorrhoids, sterility, urinary inflammations, peptic ulcer and diabetes mellitus [4,5]. Pharmacological activities including cytotoxic [6,7], antinociceptive, hepatoprotective [8,9] anti-microbial [10,11], anti-viral [12,13], anti-inflammatory [9,14,15], antioxidant [16,17], analgesic [9,18,19], spasmolytic [20][21][22], anti-ulcerogenic, gastro protective [23][24][25], and antihyperglycemic [26] activities of Cistus species have been reported. Labdane type diterpenes [7,27,28], flavonoids [9,29] flavanols and proanthocyanidins [30][31][32] were isolated from different Cistus species as active compounds.…”

Section: Introductionmentioning

confidence: 99%

Simultaneous determination of selected flavonoids from different Cistus species by HPLC-PDA

Gürbüz¹,

Koşar²,

Güvenalp³

et al. 2018

jrp

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ABSTRACT:A rapid and simple high-performance liquid chromatography method with a Photo Diode Array (PDA) detector is developed for the simultaneous analysis of seven kaempferol, quercetin and myricetin derivatives along with an acylated flavonoid glycoside; trans-tiliroside from different Cistus species. In this study, the qualitative and quantitative analysis of the methanolic extracts of three Cistus species (C. creticus L., C. laurifolius L. and C. salviifolius L.) growing in Anatolia in terms of characterization of flavonoid compounds were performed by RP-HPLC for the first time. Trans-tiliroside, a mono-coumaroyl kaempferol glucoside was found to be the most abundant flavonoid in C. salviifolius (0.276±0.003 g/100 gextract) and C. creticus (0.253±0.001 g/100 gextract) while hyperin (0.149±0.004 g/100 gextract) and myricetin 3-O-β-galactopyranoside (0.139±0.006 g/100 gextract) were found to be the most intense flavonoids in C. laurifolius samples. The described HPLC method appears suitable for the determination of the Cistus flavonols and their glycosides and can be considered as an effective and alternative procedure for the identification and quantification of this important class of biologically active compounds.

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Section: Introductionmentioning

confidence: 99%

Simultaneous determination of selected flavonoids from different Cistus species by HPLC-PDA

Gürbüz¹,

Koşar²,

Güvenalp³

et al. 2018

jrp

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“…Esto sugiere que el B. latilfolia posee un mecanismo de acción alterno al de atropina o hioscina. Aunque se conocen diversos mecanismos farmacológicos que explican el mecanismo de acción de los compuestos que relajan la musculatura lisa intestinal conocidos como antiespasmódicos, el más común es la actividad como antagonista competitivo de la Ach y, con ello, impiden la despola- 15,16 rización de la célula muscular y su consiguiente contracción.…”

Section: Discussionunclassified

“…El estudio mostró que la hioscina inhibió el efecto contráctil de Ach en 92,83 % de variación y el efecto contráctil de histamina en 95,32 % de variación, respecto a la contracción inducida, resultados que muestran un disminuido efecto relajante sobre el músculo liso intestinal en relación con la actividad relajante de los extractos (Figuras 01 y 02). Diferentes estudios han mostrado una acción relajante de atropina y hioscina cuando el íleon aislado [15][16][17][18] se contrae con Ach e histamina.…”

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Efecto sobre el músculo liso intestinal y toxicidad aguda oral de un extracto de chilca (Baccharis latifolia)

Escobar

Acebedo

2013

InCres

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El objetivo fue evaluar el efecto de un extracto hidroalcohólico del Baccharis latifolia sobre el músculo liso intestinal y toxicidad aguda oral. Material y métodos: se evaluó el efecto del extracto en el modelo in Vitro de íleon aislado de cuy estimulado con acetilcolina e histamina 10-3M, usando atropina y hioscina como fármacos de referencia. La toxicidad aguda oral se determinó mediante la dosis letal media (DL50) en ratones. Resultados: el extracto presenta relajación del músculo liso intestinal a una CE50 de 46,41 mg/mL y una estimulación del músculo a una CE de 182,2 mg/mL. La DL50 fue de 2000 mg/kg. Conclusión: El extracto presenta una actividad bifásica de tipo hormesis, que se manifiesta por una relajación prolongada del músculo liso a bajas concentraciones, seguida de un efecto espasmogénico a altas concentraciones. No se encontraron alteraciones toxicológicas.

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“…This plant is widely used in herbal medicine around the world as anti-diarrheal, antiacid and antispasmodic as visible from many ethnobotanical works. Essential oil been shown to exhibit antifungal and antibacterial effect (Aziz et al, 2006). (Stranski, 1953;Nedelcheva, 2009).…”

Section: Discussionmentioning

confidence: 99%

Medicinal plants from an old Bulgarian medical book

Nedelcheva¹

2012

J. Med. Plants Res.

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The aim of this study was to conduct an ethnobotanical research of old written sources which give information about medicinal plants and preparation of folk remedies for a particular historical period. The object of the present study is "Canon Prayer to St. Ivan Rilski and Medicinal Text" (1845)-a part of the Bulgarian early printed literature heritage. The 92 submitted recipes cover a wide range of illnesses and symptoms ranging from antiseptic to cures for neurological diseases. High species diversity of medicinal plants is represented in the book-most of them are vascular plants from 36 families (Leguminosae, Umbeliferae, Compositae, Zingiberaceae, Piperaceae, Myristicaceae, Lauraceae, Labiatae, Liliaceae, etc.) and 65 genera. The main components in written folk remedies are medicinal plants (more than 69), followed by the animals and animal products (20) such as honey, eggs, leeches, blood, musk, etc., mineral elements (sulphur (S), mercury (Hg), Au, gold (Au), iron (Fe)) and other organic and inorganic compounds (30). The significant participation of spices such as clove, cinnamon, mastic and ginger in folk remedies sheds new light on the list of species that are traditionally used in the folk medicine. The ethnobotanical study on this book, support the thesis that it was founded on authentic recipes from the healing activity of St. Ivan Rilski, which has increased its historical value a lot.

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Relaxant effect of aqueous extract of Cistus ladaniferus on rodent intestinal contractions

Cited by 21 publications

References 10 publications

Simultaneous determination of selected flavonoids from different Cistus species by HPLC-PDA

Simultaneous determination of selected flavonoids from different Cistus species by HPLC-PDA

Efecto sobre el músculo liso intestinal y toxicidad aguda oral de un extracto de chilca (Baccharis latifolia)

Medicinal plants from an old Bulgarian medical book

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