Relaxant Effect of Essential Oil of Artemisia herba-alba Asso. on Rodent Jejunum Contractions

Aziz, Mohammed; Karim, Ahmed; M, El Ouariachi el; Bouyanzer, A.; Amrani, Souliman; Mekhfi, Hassane; Ziyyat, Abderrahim; Melhaoui, Ahmed; Bnouham, Mohamed; Legssyer, Abdelkhaleq

doi:10.3797/scipharm.1106-13

Cited by 24 publications

(12 citation statements)

References 24 publications

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“…(LABSAP-9) Chih (Ap) Inf, Dec٫ Mac Gastric disorders, liver problems, wormer, muscle spasm, hypertension, COVID-19 0.76 (Eddouks et al 2002;Boudjelal et al 2013;Ouelbani et al 2016;Kharchoufa et al 2018) (Boudjelal et al 2013;Miara et al 2013Miara et al , 2019aBenarba et al 2015;Benarba 2016) infertility, menstrual cycle problems, cough, toothache 0.33 (Miara et al 2013;Benarba 2016;Ouelbani et al 2016;Hamza et al 2019) may be due to its chemical compounds as monoterpenoids, sesquiterpenoids (largely in essential oils), flavonoids, and phenolic compounds (Khlifi et al 2013;Mohamed et al 2019) Several studies studied the antispasmodic activity of the essential oil extracted from the plant's aerial parts. It was found that the administration of this oil relaxed the spontaneous tonus of the rabbit jejunum and reversed the tonic contraction of rat jejunum induced by carbachol (Aziz et al 2012). Another published study has found that the aqueous extract of this plant has increased the time of gastrointestinal transit in alloxan-treated rabbits and mice (Marrif et al 1995), and improves insulin sensitivity and hepatic steatosis in rodents-induced metabolic syndrome (Réggami et al 2019).…”

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confidence: 95%

Ethnobotanical and ethnomedicinal analysis of wild medicinal plants traditionally used in Naâma, southwest Algeria

Bouafia

Amamou

Gherib³

et al. 2021

Vegetos

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Algerian people largely rely on traditional medicine practices as part of a community's identity. This first ethnobotanical study aimed to quantify and document the wild medicinal plant taxa from four family and the related traditional knowledge in Naâma province, Algeria. The survey was carried out between 2018 and 2020. The socio-demographic data and the use of medicinal species were recorded and collected randomly from 84 indigenous people using pre-prepared questionnaire. The result was evaluated using quantitative indices. A total of 27 medicinal plant species belonging to 21 genera used in the community were mostly recorded. The most represented families were Lamiaceae and Asteraceae (12 species for each of them). The aerial parts were the most frequently used plant part (73 %), while a decoction (34 %), and infusion (31 %) were the major modes of remedy preparation. The species with high UV were Rosmarinus officinalis L. (0.80), Artemisia herba-alba Asso (0.76), and Juniperus phoenicea L. subsp. phoenicea (0.75). Species with highest FL were: Ephedra alata subsp. alenda (Stapf) Trab (100 %), Teucrium polium L. (60 %), and Ballota hirsuta Benth (57.14.5 %). Atractylis caespitosa Desf and Nepeta nepetella subsp.amethystina (Poir.) Briq were newly cited as medicinal plants and have not been recorded previously in Algeria. Artemisia herba-alba Asso and Thymus algeriensis Boiss. & Reut were reported to treat COVID-19 symptoms. The results obtained indicate the richness of the area with medicinal plants as well as knowledge of alternative medicine. The most cited plants could be contained molecules that can be tested for therapeutic uses.

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Section: )mentioning

confidence: 95%

Ethnobotanical and ethnomedicinal analysis of wild medicinal plants traditionally used in Naâma, southwest Algeria

Bouafia

Amamou

Gherib³

et al. 2021

Vegetos

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“…Relaxant effect of its essential oil on rodent jejunum contractions (Aziz et al 2012). Aniticoccidiosis effect in broilers (Messai et al 2014).…”

Section: Introductionmentioning

confidence: 99%

The use of medicinal herbs in gynecological and pregnancy-related disorders by Jordanian women: a review of folkloric practice vs. evidence-based pharmacology

Akour

Kasabri

Afifi

et al. 2016

Pharmaceutical Biology

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Context National statistical reports in Jordan indicate a decrease in the total fertility rate along with a parallel increase in contraceptive use. The folkloric use of medicinal herbs in gynecological disorders has been growing in Jordan, despite of deficient reports on the evidence-based safety and efficacy of these practices. Objective The aim of this comprehensive article is to review medicinal plants with claimed ethnonpharmacological usage in various gynecological and pregnancy-related issues in Jordan, and to assess their evidence-based pharmacological studies as well as their phytochemistry. Methods The published literature was surveyed using Google Scholar entering the terms ''ethnopharmacology AND Jordan AND infertility AND gynecology OR gestation''. We included ethnopharmacological surveys in Jordan with available full-text. Results Twelve articles were reviewed. Plant species which are commonly used for female gynecological issues such as Artemisia monosperma Del. and A. herba-alba Asso. (Asteraceae) have been found to exert an antifertility effect. Ricinus communis L. (Euphorbiaceae) and Citrullus colocynthis (L.) Schrad. (Cucurbitaceae) had antifertility effects in male rats, but Nigella sativa oil L. (Ranunculaceae) and Cinnamon zeylanicum J. Presl (Lauraceae) were found to enhance it. Conclusion Using plants for gynecological disorders is a common practice in Jordan. Many of them, whether utilised for gynecological or non-gynecological conditions equally, were found to have detrimental effects on female or male fertility. Thus, couples planning pregnancy should be discouraged from the consumption of these herbs. Further local studies are warranted to confirm the appreciable beneficial pharmacological effects and safety of these plants. ARTICLE HISTORY

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“…[10][11][12] Many studies have demonstrated the effect of free radical scavenging, antimicrobial activities, anticarcinogenicity 13,14 and dilation of blood vessel. [15][16][17][18] Recently, it has been also shown that the extract from Artemisia species had the vasorelaxing activity on thoracic aorta in rat through the endothelial NOS (eNOS)/cGMP pathway. 19,20 The penis is a vascular organ and has similar physical characteristics in vascular smooth muscle.…”

Section: Introductionmentioning

confidence: 99%

Additive effects of Artemisia capillaris extract and scopoletin on the relaxation of penile corpus cavernosum smooth muscle

Kumar

Zhao

et al. 2015

Int J Impot Res

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The objective was to investigate the cellular effect and action mechanism of Artemisia capillaris extract (ACE) and its component, scopoletin, on penile corpus cavernosum smooth muscle (PCCSM). In vitro study with PCCSM, the precontracted PCCSM with phenylephrine was treated with ACE or scopoletin. Cyclic nucleotides in the perfusate were measured by radioimmunoassay and expression of protein and mRNA of endothelial nitric oxide synthase (eNOS) and neuronal nitric oxide synthase in the perfused PCCSM were measured by western blot and real-time PCR, respectively. The interaction of ACE or scopoletin with udenafil was also evaluated. ACE and scopoletin exerted a significant and concentration-dependent relaxation in PCCSM. The perfusion with ACE or scopoletin significantly increased cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) and the perfusion with ACE or scopoletin increased the expression of eNOS mRNA and protein. Furthermore, ACE or scopoletin enhanced udenafil-inducing relaxation in PCCSM. ACE and scopoletin relaxed the PCCSM mainly by activating nitric oxide-cGMP system and cAMP pathway and they may be additive therapeutic candidates for ED patients who do not completely respond to udenafil.

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Relaxant Effect of Essential Oil of Artemisia herba-alba Asso. on Rodent Jejunum Contractions

Cited by 24 publications

References 24 publications

Ethnobotanical and ethnomedicinal analysis of wild medicinal plants traditionally used in Naâma, southwest Algeria

Ethnobotanical and ethnomedicinal analysis of wild medicinal plants traditionally used in Naâma, southwest Algeria

The use of medicinal herbs in gynecological and pregnancy-related disorders by Jordanian women: a review of folkloric practice vs. evidence-based pharmacology

Additive effects of Artemisia capillaris extract and scopoletin on the relaxation of penile corpus cavernosum smooth muscle

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