Relaxant effect of ethanol extract of<i>Carum carvi</i>on dispersed intestinal smooth muscle cells of the guinea pig

Al-Essa, Mohammed K.; Shafagoj, Yanal; Mohammed, Faysal I.; Afifi, Fatma U.

doi:10.3109/13880200903046161

Cited by 24 publications

(12 citation statements)

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“… a Assessment = conclusion of a reference on a hypothesized effect; b reference = trial x plant species x indication; c particularly unspecified or infectious diarrhea and gastrointestinal spasms + = reference proves evidently the hypothesized effect; ? = reference shows uncertain hypothesized effect; o = reference does not prove evidently the hypothesized effect 1 [ 147 , 148 ] 2 [ 149 – 152 ] 3 [ 153 ] 4 [ 154 ] 5 [ 69 – 76 , 155 – 158 ] 6 [ 69 ] 7 [ 63 , 66 ] 8 [ 159 ] 9 [ 62 , 160 ] 10 [ 63 , 64 ] 11 [ 66 ] 12 [ 77 ] 13 [ 161 , 162 ] 14 [ 163 , 164 ] 15 [ 165 – 170 ] 16 [ 170 ] 17 [ 171 ] 18 [ 172 ] 19 [ 124 , 125 ] 20 [ 124 , 173 ] 21 [ 174 – 176 ] 22 [ 177 ] 23 [ 178 ] 24 [ 179 ] 25 [ 175 , 176 , 180 – 183 ] 26 [ 184 ] 27 [ 185 ] 28 [ 181 ] 29 [ 186 ] 30 [ ...…”

Section: Resultsmentioning

confidence: 99%

Medicinal plants – prophylactic and therapeutic options for gastrointestinal and respiratory diseases in calves and piglets? A systematic review

et al. 2016

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BackgroundGastrointestinal and respiratory diseases in calves and piglets lead to significant economic losses in livestock husbandry. A high morbidity has been reported for diarrhea (calves ≤ 35 %; piglets ≤ 50 %) and for respiratory diseases (calves ≤ 80 %; piglets ≤ 40 %). Despite a highly diverse etiology and pathophysiology of these diseases, treatment with antimicrobials is often the first-line therapy. Multi-antimicrobial resistance in pathogens results in international accordance to strengthen the research in novel treatment options. Medicinal plants bear a potential as alternative or additional treatment. Based on the versatile effects of their plant specific multi-component-compositions, medicinal plants can potentially act as ‘multi-target drugs’. Regarding the plurality of medicinal plants, the aim of this systematic review was to identify potential medicinal plant species for prevention and treatment of gastrointestinal and respiratory diseases and for modulation of the immune system and inflammation in calves and piglets.ResultsBased on nine initial sources including standard textbooks and European ethnoveterinary studies, a total of 223 medicinal plant species related to the treatment of gastrointestinal and respiratory diseases was identified. A defined search strategy was established using the PRISMA statement to evaluate 30 medicinal plant species starting from 20’000 peer-reviewed articles published in the last 20 years (1994–2014). This strategy led to 418 references (257 in vitro, 84 in vivo and 77 clinical trials, thereof 48 clinical trials in veterinary medicine) to evaluate effects of medicinal plants and their efficacy in detail. The findings indicate that the most promising candidates for gastrointestinal diseases are Allium sativum L., Mentha x piperita L. and Salvia officinalis L.; for diseases of the respiratory tract Echinacea purpurea (L.) MOENCH, Thymus vulgaris L. and Althea officinalis L. were found most promising, and Echinacea purpurea (L.) MOENCH, Camellia sinensis (L.) KUNTZE, Glycyrrhiza glabra L. and Origanum vulgare L. were identified as best candidates for modulation of the immune system and inflammation.ConclusionsSeveral medicinal plants bear a potential for novel treatment strategies for young livestock. There is a need for further research focused on gastrointestinal and respiratory diseases in calves and piglets, and the findings of this review provide a basis on plant selection for future studies.Electronic supplementary materialThe online version of this article (doi:10.1186/s12917-016-0714-8) contains supplementary material, which is available to authorized users.

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Section: Resultsmentioning

confidence: 99%

Medicinal plants – prophylactic and therapeutic options for gastrointestinal and respiratory diseases in calves and piglets? A systematic review

et al. 2016

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“…It is known to desensitize, via TRPM8, the TRPV1 receptor which is relevant in visceral nociception in IBS and the maternal separation model . Menthol is also a smooth muscle calcium channel antagonists that causes (similar to caraway) muscle relaxation. This may be beneficial because dysmotility in IBS was shown to correlate with abdominal pain.…”

Section: Discussionmentioning

confidence: 99%

Reversal of visceral hypersensitivity in rat by Menthacarin^®, a proprietary combination of essential oils from peppermint and caraway, coincides with mycobiome modulation

Botschuijver

Welting

Levin

et al. 2018

Neurogastroenterology Motil

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Abbreviations: DSS, dextran sulfate sodium; IBS, irritable bowel syndrome; ITS-1, internal transcribed spacer-1; OTU, operational taxonomic unit; TNBS, trinitrobenzene sulphonic acid; TRPM8, transient receptor potential ion channel melastatin subtype 8; TRPV1, transient receptor potential cation channel subfamily v member 1; WA, water avoidance. AbstractBackground: Irritable bowel syndrome (IBS) is a common gastrointestinal disorder as-

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“…[132] The antispasmodic effect of an alcoholic extract of caraway has shown inhibitory effects on smooth muscle contractions induced by the spasmogens, acetylcholine and histamine. [133134] This response has been evaluated to explain the beneficial effect of caraway in relieving gastrointestinal symptoms associated with dyspepsia. In a study done on 12 intestinal bacteria, caraway oil displayed high degree of selectivity, inhibiting the growth of potential pathogens at concentrations that had no effect on the beneficial bacteria examined.…”

Section: Biological and Pharmacological Activitymentioning

confidence: 99%

Cuminum cyminum and Carum carvi: An update

2011

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Cuminum cyminum and Carum carvi are the sources of cumin and caraway seeds respectively, which have been used since antiquity for the treatment of various indications in traditional healing systems in wide geographical areas. Cumin and caraway seeds are rich sources of essential oils and have been actively researched for their chemical composition and biological activities. In recent times (especially during the last 3 years) considerable progress has been made regarding validation of their acclaimed medicinal attributes by extensive experimental studies. In this attempt many novel bioactivities have been revealed. This review highlights the significance of cumin and caraway as potential source of diverse natural products and their medicinal applications.

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Relaxant effect of ethanol extract ofCarum carvion dispersed intestinal smooth muscle cells of the guinea pig

Cited by 24 publications

References 20 publications

Medicinal plants – prophylactic and therapeutic options for gastrointestinal and respiratory diseases in calves and piglets? A systematic review

Medicinal plants – prophylactic and therapeutic options for gastrointestinal and respiratory diseases in calves and piglets? A systematic review

Reversal of visceral hypersensitivity in rat by Menthacarin^®, a proprietary combination of essential oils from peppermint and caraway, coincides with mycobiome modulation

Cuminum cyminum and Carum carvi: An update

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Relaxant effect of ethanol extract ofCarum carvion dispersed intestinal smooth muscle cells of the guinea pig

Cited by 24 publications

References 20 publications

Medicinal plants – prophylactic and therapeutic options for gastrointestinal and respiratory diseases in calves and piglets? A systematic review

Medicinal plants – prophylactic and therapeutic options for gastrointestinal and respiratory diseases in calves and piglets? A systematic review

Reversal of visceral hypersensitivity in rat by Menthacarin®, a proprietary combination of essential oils from peppermint and caraway, coincides with mycobiome modulation

Cuminum cyminum and Carum carvi: An update

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Product

Resources

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Reversal of visceral hypersensitivity in rat by Menthacarin^®, a proprietary combination of essential oils from peppermint and caraway, coincides with mycobiome modulation