Relaxant Response of Isolated Basilar Arteries to Calcitonin Gene-Related Peptide in Stroke-Prone Spontaneously Hypertensive Rats

Nishimura, Yoshitaka; Usui, Hachiro; Suzuki, Aritomo; Kajimoto, Noriyoshi; Yamanishi, Yukinori

doi:10.1016/s0021-5198(19)37630-9

Cited by 3 publications

(1 citation statement)

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“…This study demonstrated that CGRP induced potent relaxation in the 3rd branches of rat renal arteries via an endothelium-independent mechanism . It has been reported that CGRP did not require intact endothelium to produce relaxation of rat basilar (Nishimura et al ., 1992), gastric, splenic, and hepatic arteries (Bratveit et al, 1991;). However, it has been shown that CGRP produced vasodilation of the rat aorta (Brain et al ., 1985;Kubota et al, 1985;Grace et al, 1987) and superior mesenteric artery (Bratveit et al ., 1991) in an endothelium-dependent manner.…”

Section: Discussionmentioning

confidence: 94%

Relaxant Effects of Calcitonin Gene-related Peptide on Isolated Small Renal Arteries in Stroke-Prone Spontaneously Hypertensive Rats.

Gao

Nishimura

Suzuki

et al. 1994

J. Smooth Muscle Res.

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The relaxant effects of calcitonin gene-related peptide (CGRP) on the 3rd branches of renal arteries obtained from stroke-prone spontaneously hypertensive rats (SHRSP) ,and Wistar-Kyoto rats (WKY) were investigated in vitro . CGRP elicited concentrationdependent relaxation, and the relaxant response was not affected by the mechanical removal of endothelium in either SHRSP or WKY. The CGRP-induced relaxant response was markedly greater in SHRSP than in WKY , whereas there was no significant difference in acetylcholine-induced relaxation, which was endothelium-dependent , between the two groups. Additionally, significantly enhanced reactivity to CGRP was also shown in spontaneously hypertensive rats compared to WKY; however , this reactivity was less than that observed in SHRSP.There were also no significant differences between WKY and SHRSP in the relaxation induced by forskolin, dibutyryl cyclic AMP, and 3-isobutyl-1-methylxanthine (IBMX). CGRP-induced relaxation was significantly potentiated in similar manner by the pretreatment with IBMX in both WKY and SHRSP.Incubation with glibenclamide (10-6 M) had no effect on CGRP-induced relaxation in either group, the WKY or the SHRSP. These results suggest that CGRP produces endothelium-independent relaxation in the small renal arteries in the rat, and that the increased CGRP-induced relaxant response found in SHRSP may not be associated with the altered vasodilation mediated by cyclic AMP , or with functional changes in ATP-sensitive potassium channels .

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