Relaxation response of abdominal aorta to androgens in orchidectomised Sprague–Dawley rats fed a high-salt diet

Oloyo, Ahmed Kolade; Nair, R. V.; Anigbogu, C.N.; Sofola, OA

doi:10.1139/y2012-132

Cited by 5 publications

(5 citation statements)

References 17 publications

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“…Since most high-salt diets that were used in the scientific literature were composed with levels up to 8% NaCl [ 65 , 66 ], this value was chosen as a reference. In accordance with Oloyo et al, food pellets usually given to rats were mixed with water to form a smooth paste, then salt (7.75% of the total food weight) was added to reach the desired salt concentration of 8% and pellets were reconstituted before being dried for 24 h [ 67 ].…”

Section: Methodsmentioning

confidence: 99%

Biocompatibility of Four Common Orthopedic Biomaterials Following a High-Salt Diet: An In Vivo Study

Lecocq

Bernard

Félix

et al. 2017

IJMS

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Nowadays, salt consumption appears to be drastically above the recommended level in industrialized countries. The health consequences of this overconsumption are heavy since high-salt intake induces cardiovascular disease, kidney dysfunction, and stroke. Moreover, harmful interaction may also occur with orthopaedic devices because overconsumption of salt reinforces the corrosive aspect of biological tissues and favors bone resorption process. In the present study, we aimed to assess the in vivo effect of three weeks of a high-salt diet, associated (or not) with two weeks of the neuro-myoelectrostimulation (NMES) rehabilitation program on the biocompatibility of four biomaterials used in the manufacture of arthroplasty implants. Thus, two non-metallic (PEEK and Al2O3) and two metallic (Ti6Al4V and CrCo) compounds were implanted in the rat tibial crest, and the implant-to-bone adhesion and cell viability of two surrounded muscles, the Flexor Digitorum (FD) and Tibialis Anterior (TA), were assessed at the end of the experiment. Results indicated lower adhesion strength for the PEEK implant compared to other biomaterials. An effect of NMES and a high-salt diet was only identified for Al2O3 and Ti6Al4V implants, respectively. Moreover, compared to a normal diet, a high-salt diet induced a higher number of dead cells on both muscles for all biomaterials, which was further increased for PEEK, Al2O3, and CrCo materials with NMES application. Finally, except for Ti6Al4V, NMES induced a higher number of dead cells in the directly stimulated muscle (FD) compared to the indirectly stimulated one (TA). This in vivo experiment highlights the potential harmful effect of a high-salt diet for people who have undergone arthroplasty, and a rehabilitation program based on NMES.

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Section: Methodsmentioning

confidence: 99%

Biocompatibility of Four Common Orthopedic Biomaterials Following a High-Salt Diet: An In Vivo Study

Lecocq

Bernard

Félix

et al. 2017

IJMS

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show abstract

“…Since most high-salt diets that were used in the scientific literature were composed with levels up to 8% NaCl [ 26 ], this value was chosen as reference. In accordance with Oloyo et al food pellets usually given to rats were mixed with water to form a smooth paste, then salt (7.75% of the total food weight) was added to reach the desired salt concentration of 8% and pellets were reconstituted before being dried for 24 hours [ 27 ].…”

Section: Methodsmentioning

confidence: 99%

Titanium Implant Impairment and Surrounding Muscle Cell Death Following High-Salt Diet: An In Vivo Study

et al. 2016

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Aim of the studyHigh-salt consumption has been widely described as a risk factor for cardiovascular, renal and bone functions. In the present study, the extent to which high-salt diet could influence Ti6Al4V implant surface characteristic, its adhesion to rat tibial crest, and could modify muscle cell viability of two surrounding muscles, was investigated in vivo. These parameters have also been assessed following a NMES (neuro-myoelectrostimulation) program similar to that currently used in human care following arthroplasty.ResultsAfter a three-week diet, a harmful effect on titanium implant surface and muscle cell viability was noted. This is probably due to salt corrosive effect on metal and then release of toxic substance around biologic tissue. Moreover, if the use of NMES with high-salt diet induced muscles damages, the latter were higher when implant was added. Unexpectedly, higher implant-to-bone adhesion was found for implanted animals receiving salt supplementation.ConclusionOur in vivo study highlights the potential dangerous effect of high-salt diet in arthroplasty based on titanium prosthesis. This effect appears to be more important when high-salt diet is combined with NMES.

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“…Our earlier results were later confirmed using the pressurized mesenteric artery preparation (Sofola et al 2002) during the author's appointment as a British Heart Foundation Fellow at Leeds University. However, on return to Nigeria, such facilities were not available but we are still publishing using the ring preparation (Oloyo et al 2012) although we have recently acquired digital recorders for research work with better results (unpublished). The image above shows our old faithful, the Model 7D Grass polygraph, which we are currently using.…”

Section: University Of Lagos Nigeriamentioning

confidence: 99%

Outreach report: Promoting physiology and related careers in schools

Amici-Dargan¹

2014

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Features 18 Teaching and research in physiology in Sub-Saharan Africa: achievements and challenges 22 Have the carotid chemoreceptors anything to do with the control of breathing during exercise in man? 26 A portal to pain: the transient receptor potential (TRP) vanilloid 1 channel 32 The Wanderer returns: myths and realities of the cardiac vagus 39 Letter to David Hubel 42 Our hyper-polarizing story: understanding ATP-mediated vasodilatation in humans Membership 47 Outreach report: Arnold Hill Academy pupils visit the

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Relaxation response of abdominal aorta to androgens in orchidectomised Sprague–Dawley rats fed a high-salt diet

Cited by 5 publications

References 17 publications

Biocompatibility of Four Common Orthopedic Biomaterials Following a High-Salt Diet: An In Vivo Study

Biocompatibility of Four Common Orthopedic Biomaterials Following a High-Salt Diet: An In Vivo Study

Titanium Implant Impairment and Surrounding Muscle Cell Death Following High-Salt Diet: An In Vivo Study

Outreach report: Promoting physiology and related careers in schools

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